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Nutraceutical Management Of Alzheimer’s Disease
Corresponding Author(s) : S. Revathy
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 12 No. 2 (2024): 2024 Volume -12 - Issue 2
Abstract
The Alzheimer’s disease is explains as paralysis agitans or shacking palsy, it is one of the neurodegerative disease produce the major symptom is damaging the memory power. Plaques and tangles block the communication between the nerve cells, prevents them from carrying out their signaling process. Mental status and neuropsycological testing may provide many details about mental function. In human brain contains over 100 billion nerve cells and other cells. The nerve cells work together to fulfill all communication needed to perform functions such as thinking and learning. This process is collapse with brain cell death forms the Alzheimer’s disease. Early onset - family hereditary Alzheimer’s disease (EO - FAD) are strongly linked to gene. Sudden changes in amyloid precursor protein causes the Alzheimer’s disease. In initial stages, terrible loss of brain function can cause malnutrition, dehydration or infection. The brain shrunk significantly in the final stage. The pathological symptom is the frontal and temporal cortices has enlarged sulcal spaces with atrophy. Complications of Alzheimer’s disease cause the bladder and bowel problems. This condition results from restricted movement and limited communication to other people. The symptoms of depression may include sleeping problem and changes in mood. These symptoms are minimized with the nutraceutical products. The nutraceutical are formulation with the herbal plants which helps in prevention and treatment of some diseases. The drugs includes the almonds, walnuts, pomegranate seeds and dates, etc… These are helps for reducing certain diseases.
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- DeTure MA, Dickson DW. The neuropathological diagnosis of Alzheimer's disease. MolNeurodegener. 2019 Aug 2;14(1):32. doi: 10.1186/s13024-019-0333-5. PMID:31375134; PMCID: PMC6679484.
- Andrade V, Guzman-Martinez L, Cortes N, Gonzalez A, Farias G, Maccioni RB. The Emergency of Nutraceutical Compounds in the Preventive Medicine Scenario. Potential for Treatment of Alzheimers Disease and Other Chronic Disorders. J Alzheimers Dis Parkinsonism. 2018;8(456):2161-0460. https://www.academia.edu/download/101988531/d03f52d84e2e9d8b4b3ad77b1cfb1a8016c8.pdf
- https://my.clevelandclinic.org/health/diseases/9164-Alzheimer's disease
- Farías GA, Guzmán-Martínez L, Delgado C, Maccioni RB. Nutraceuticals: a novel concept in prevention and treatment of Alzheimer's disease and related disorders. J Alzheimers Dis. 2014;42(2):357-67. doi: 10.3233/JAD-132741. PMID: 24927706.
- https://www.alz.org/Alzheimer's-dementia/what-is-alzheimers/causes and risk factors.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428020/
- https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447
- https://www.alzra.org/alzheimers/alzheimers-diagnosis/
- Breijyeh Z, Karaman R. Comprehensive Review on Alzheimer's Disease: Causes and Treatment. Molecules. 2020 Dec 8;25(24):5789. doi: 10.3390/molecules25245789. PMID: 33302541; PMCID: PMC7764106.
- Armstrong RA. What causes alzheimer's disease? Folia Neuropathol. 2013;51(3):169-88. doi:10.5114/fn.2013.37702. PMID: 24114635.
- A. Armstrong R. Risk factors for Alzheimer's disease. Folia Neuropathol. 2019;57(2):87-105. doi: 10.5114/fn.2019.85929. PMID: 31556570.
- https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms- causes/syc-20350447
- https://www.healthline.com/health/alzheimers-disease-complications
- https://www.nia.nih.gov/health/alzheimers-caregiving/alzheimers-disease-common- medical-problems
- https://www.tandfonline.com/toc/dijg20/2012?nav=tocList
- Perl DP. Neuropathology of Alzheimer's disease. Mt Sinai J Med. 2010 Jan-Feb;77(1):32-42. doi: 10.1002/msj.20157. PMID: 20101720; PMCID: PMC2918894.
- Talebi M, Kakouri E, Talebi M, Tarantilis PA, Farkhondeh T, İlgün S, Pourbagher-Shahri AM, Samarghandian S. Nutraceuticals-based therapeutic approach: recent advances to combat pathogenesis of Alzheimer's disease. Expert Rev Neurother. 2021 Jun;21(6):625-642. doi: 10.1080/14737175.2021.1923479. Epub 2021 May 16. PMID: 33910446.
- Thakur AK, Kamboj P, Goswami K. Pathophysiology and management of alzheimer’s disease: an overview. J Anal Pharm Res. 2018;9(2):226?235. DOI: 10.15406/japlr.2018.07.00230
- https://www.neurologylive.com/view/pathophysiology-of-alzheimer-s-disease
- https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/in-depth/alzheimers/art-20048103
- https://www.webmd.com/alzheimers/alzheimers-disease-treatment-overview
- Soumyanath A, Zhong YP, Henson E, Wadsworth T, Bishop J, Gold BG, Quinn JF. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease:
- Investigation of a Possible Mechanism of Action. Int J Alzheimers Dis. 2012;2012:381974. doi: 10.1155/2012/381974. Epub 2012 Feb 15. PMID: 22506133; PMCID: PMC3296229.[23] https://www.sciencedirect.com/science/article/abs/pii/S0924224417305587
- Riaz S, Hussain I, Ibrahim M, Ishtiaq M, Ali Q, Muazzam Ali M, Sajid Hamid Akash M. Extraction and Optimization of Active Metabolites From Cluster Bean: An In Vitro Biological and Phytochemical Investigation. Dose Response. 2022 May 7;20(2):15593258221098992. doi: 10.1177/15593258221098992. PMID: 35558873; PMCID: PMC9087274.
- Byerley LO, Chang HM, Lorenzen B, Guidry J, Hardman WE. Impact of dietary walnuts, a nutraceutical option, on circulating markers of metabolic dysregulation in a rodent cachectic tumor model. Biomed Pharmacother. 2022 Nov;155:113728. doi: 10.1016/j.biopha.2022.113728. Epub 2022 Sep 21. PMID: 36152410; PMCID: PMC9618292.
- Caltagirone C, Peano C, Sottile F. Post-harvest Industrial Processes of Almond (Prunus dulcis L. Mill) in Sicily Influence the Nutraceutical Properties of By-Products at Harvest and During Storage. Front Nutr. 2021 Jun 2;8:659378. doi: 10.3389/fnut.2021.659378. PMID: 34150827; PMCID: PMC8206266.
- https://www.foodnavigator-asia.com/Article/2011/04/18/Great-potential-of-immature-rice-grains-for-nutraceuticals-Study[28] Lee WS, Lee HJ, Yang JY, Shin HL, Choi SW, Kim JK, Seo WD, Kim EH. The Potential
- Neuroprotective Effects of Extracts from Oat Seedlings against Alzheimer's Disease. Nutrients.2022 Oct 2;14(19):4103. doi: 10.3390/nu14194103. PMID: 36235754; PMCID: PMC9571310.
- https://www.eurekaselect.com/article/131821
- Ain HBU, Tufail T, Bashir S, Ijaz N, Hussain M, Ikram A, Farooq MA, Saewan SA. Nutritional importance and industrial uses of pomegranate peel: A critical review. Food Sci Nutr. 2023 Mar 23;11(6):2589-2598. doi: 10.1002/fsn3.3320. PMID: 37324891; PMCID: PMC10261788.
- https://www.medicalnewstoday.com/articles/322899
- Subash S, Essa MM, Braidy N, Awlad-Thani K, Vaishnav R, Al-Adawi S, Al-Asmi A, Guillemin GJ. Diet rich in date palm fruits improves memory, learning and reduces beta amyloid in transgenic mouse model of Alzheimer's disease. J Ayurveda Integr Med. 2015 Apr-Jun;6(2):111- 20.doi: 10.4103/0975-9476.159073. PMID: 26167001; PMCID: PMC4484046.
References
DeTure MA, Dickson DW. The neuropathological diagnosis of Alzheimer's disease. MolNeurodegener. 2019 Aug 2;14(1):32. doi: 10.1186/s13024-019-0333-5. PMID:31375134; PMCID: PMC6679484.
Andrade V, Guzman-Martinez L, Cortes N, Gonzalez A, Farias G, Maccioni RB. The Emergency of Nutraceutical Compounds in the Preventive Medicine Scenario. Potential for Treatment of Alzheimers Disease and Other Chronic Disorders. J Alzheimers Dis Parkinsonism. 2018;8(456):2161-0460. https://www.academia.edu/download/101988531/d03f52d84e2e9d8b4b3ad77b1cfb1a8016c8.pdf
https://my.clevelandclinic.org/health/diseases/9164-Alzheimer's disease
Farías GA, Guzmán-Martínez L, Delgado C, Maccioni RB. Nutraceuticals: a novel concept in prevention and treatment of Alzheimer's disease and related disorders. J Alzheimers Dis. 2014;42(2):357-67. doi: 10.3233/JAD-132741. PMID: 24927706.
https://www.alz.org/Alzheimer's-dementia/what-is-alzheimers/causes and risk factors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428020/
https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447
https://www.alzra.org/alzheimers/alzheimers-diagnosis/
Breijyeh Z, Karaman R. Comprehensive Review on Alzheimer's Disease: Causes and Treatment. Molecules. 2020 Dec 8;25(24):5789. doi: 10.3390/molecules25245789. PMID: 33302541; PMCID: PMC7764106.
Armstrong RA. What causes alzheimer's disease? Folia Neuropathol. 2013;51(3):169-88. doi:10.5114/fn.2013.37702. PMID: 24114635.
A. Armstrong R. Risk factors for Alzheimer's disease. Folia Neuropathol. 2019;57(2):87-105. doi: 10.5114/fn.2019.85929. PMID: 31556570.
https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms- causes/syc-20350447
https://www.healthline.com/health/alzheimers-disease-complications
https://www.nia.nih.gov/health/alzheimers-caregiving/alzheimers-disease-common- medical-problems
https://www.tandfonline.com/toc/dijg20/2012?nav=tocList
Perl DP. Neuropathology of Alzheimer's disease. Mt Sinai J Med. 2010 Jan-Feb;77(1):32-42. doi: 10.1002/msj.20157. PMID: 20101720; PMCID: PMC2918894.
Talebi M, Kakouri E, Talebi M, Tarantilis PA, Farkhondeh T, İlgün S, Pourbagher-Shahri AM, Samarghandian S. Nutraceuticals-based therapeutic approach: recent advances to combat pathogenesis of Alzheimer's disease. Expert Rev Neurother. 2021 Jun;21(6):625-642. doi: 10.1080/14737175.2021.1923479. Epub 2021 May 16. PMID: 33910446.
Thakur AK, Kamboj P, Goswami K. Pathophysiology and management of alzheimer’s disease: an overview. J Anal Pharm Res. 2018;9(2):226?235. DOI: 10.15406/japlr.2018.07.00230
https://www.neurologylive.com/view/pathophysiology-of-alzheimer-s-disease
https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/in-depth/alzheimers/art-20048103
https://www.webmd.com/alzheimers/alzheimers-disease-treatment-overview
Soumyanath A, Zhong YP, Henson E, Wadsworth T, Bishop J, Gold BG, Quinn JF. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease:
Investigation of a Possible Mechanism of Action. Int J Alzheimers Dis. 2012;2012:381974. doi: 10.1155/2012/381974. Epub 2012 Feb 15. PMID: 22506133; PMCID: PMC3296229.[23] https://www.sciencedirect.com/science/article/abs/pii/S0924224417305587
Riaz S, Hussain I, Ibrahim M, Ishtiaq M, Ali Q, Muazzam Ali M, Sajid Hamid Akash M. Extraction and Optimization of Active Metabolites From Cluster Bean: An In Vitro Biological and Phytochemical Investigation. Dose Response. 2022 May 7;20(2):15593258221098992. doi: 10.1177/15593258221098992. PMID: 35558873; PMCID: PMC9087274.
Byerley LO, Chang HM, Lorenzen B, Guidry J, Hardman WE. Impact of dietary walnuts, a nutraceutical option, on circulating markers of metabolic dysregulation in a rodent cachectic tumor model. Biomed Pharmacother. 2022 Nov;155:113728. doi: 10.1016/j.biopha.2022.113728. Epub 2022 Sep 21. PMID: 36152410; PMCID: PMC9618292.
Caltagirone C, Peano C, Sottile F. Post-harvest Industrial Processes of Almond (Prunus dulcis L. Mill) in Sicily Influence the Nutraceutical Properties of By-Products at Harvest and During Storage. Front Nutr. 2021 Jun 2;8:659378. doi: 10.3389/fnut.2021.659378. PMID: 34150827; PMCID: PMC8206266.
https://www.foodnavigator-asia.com/Article/2011/04/18/Great-potential-of-immature-rice-grains-for-nutraceuticals-Study[28] Lee WS, Lee HJ, Yang JY, Shin HL, Choi SW, Kim JK, Seo WD, Kim EH. The Potential
Neuroprotective Effects of Extracts from Oat Seedlings against Alzheimer's Disease. Nutrients.2022 Oct 2;14(19):4103. doi: 10.3390/nu14194103. PMID: 36235754; PMCID: PMC9571310.
https://www.eurekaselect.com/article/131821
Ain HBU, Tufail T, Bashir S, Ijaz N, Hussain M, Ikram A, Farooq MA, Saewan SA. Nutritional importance and industrial uses of pomegranate peel: A critical review. Food Sci Nutr. 2023 Mar 23;11(6):2589-2598. doi: 10.1002/fsn3.3320. PMID: 37324891; PMCID: PMC10261788.
https://www.medicalnewstoday.com/articles/322899
Subash S, Essa MM, Braidy N, Awlad-Thani K, Vaishnav R, Al-Adawi S, Al-Asmi A, Guillemin GJ. Diet rich in date palm fruits improves memory, learning and reduces beta amyloid in transgenic mouse model of Alzheimer's disease. J Ayurveda Integr Med. 2015 Apr-Jun;6(2):111- 20.doi: 10.4103/0975-9476.159073. PMID: 26167001; PMCID: PMC4484046.