A Case Report on Drug-Induced Bullous Pemphigoid
Corresponding Author(s) : Alina Rajan
tharasilalina98@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 11 No. 2 (2023): 2023 Volume -11 - Issue 2
Abstract
This is a case presentation of a 69-year-old male patient presented with pruritic bullous lesions for one month onset located all over the body including genitals. This can be drug-induced as Hydrochlorothiazide, a diuretic can cause bullous pemphigoid, the patient was taking the drug for the past 7 years for his hypertensive condition. The lesions and blisters were cured by providing oral corticosteroids and withdrawal of the suspected drug. Bullous pemphigoid is a dermatological autoimmune condition that can be diagnosed by physical examination, histopathology, and serological assays. Mild conditions are treated using Intravenous antibiotics, and topical corticosteroids, and moderate to severe conditions are treated by systemic corticosteroids and immunosuppressants.
Keywords
Bullous
lesions
corticosteroids
autoimmune
immunosuppressants
1.
Alina Rajan, Alfiya R, Bincy Babu, Shaiju S Dharan. A Case Report on Drug-Induced Bullous Pemphigoid. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2023 Jun. 19 [cited 2026 Apr. 12];11(2):206-9. Available from: https://ijamscr.com/ijamscr/article/view/1329
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References
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1. Lee JJ, Downham 2nd TF. Furosemide-induced bullous pemphigoid: case report and review of literature. J Drugs Dermatol. 2006 Jun 1;5(6):562-4. PMID 16774111.
2. Cohen PR. Dyshidrosiform bullous pemphigoid: case reports and review. Cureus. 2020 Jan 11;12(1):e6630. doi: 10.7759/cureus.6630, PMID 32064205.
3. Patsatsi A, Vyzantiadis TA, Chrysomallis F, Devliotou?Panagiotidou D, Sotiriadis D. Medication history of a series of patients with bullous pemphigoid from northern Greece–observations and discussion. Int J Dermatol. 2009 Feb;48(2):132-5. doi: 10.1111/j.1365-4632.2009.03839.x, PMID 19200186.
4. Moro F, Fania L, Sinagra JLM, Salemme A, Di Zenzo G. Bullous pemphigoid: trigger and predisposing factors. Biomolecules. 2020;10(10):1432. doi: 10.3390/biom10101432, PMID 33050407.
5. Miyamoto D, Santi CG, Aoki V, Maruta CW. Bullous pemphigoid. An Bras Dermatol. 2019 May 9;94(2):133-46. doi: 10.1590/abd1806-4841.20199007, PMID 31090818.
6. Verheyden MJ, Bilgic A, Murrell DF. A systematic review of drug-induced pemphigoid. Actadermato-Venereol. 2020 Aug 17;100(15):1-9.
7. Asbrink E, Hovmark A. Clinical variations in bullous pemphigoid with respect to early symptoms. Acta Derm Venereol. 1981 Jan 1;61(5):417-21. doi: 10.2340/0001555561417421, PMID 6172930.
8. Bakker CV, Terra JB, Pas HH, Jonkman MF. Bullous pemphigoid as pruritus in the elderly: a common presentation. JAMA Dermatol. 2013 Aug 1;149(8):950-3. doi: 10.1001/jamadermatol.2013.756, PMID 23804286.
9. Bernard P, Antonicelli F. Bullous pemphigoid: a review of its diagnosis, associations and treatment. Am J Clin Dermatol. 2017 Aug;18(4):513-28. doi: 10.1007/s40257-017-0264-2, PMID 28247089.
10. Bakker CV, Terra JB, Pas HH, Jonkman MF. Bullous pemphigoid as pruritus in the elderly: a common presentation. JAMA Dermatol. 2013 Aug 1;149(8):950-3. doi: 10.1001/jamadermatol.2013.756, PMID 23804286.
11. Beutner EH, Lever WF, Witebsky E, Jordon R, Chertock B. Autoantibodies in pemphigus vulgaris: RESPONSE TO AN INTERCELLULAR SUBSTANCE OF EPIDERMIS. JAMA. 1965;192:682-8. doi: 10.1001/jama.1965.03080210026006, PMID 14280515.
12. Khumalo NP, Murrell DF, Wojnarowska F, Kirtschig G. A systematic review of treatments for bullous pemphigoid. Arch Dermatol. 2002 Mar 1;138(3):385-9. doi: 10.1001/archderm.138.3.385, PMID 11902990.
13. Berk MA, Lorincz AL. The treatment of bullous pemphigoid with tetracycline and niacinamide: a preliminary report. Arch Dermatol. 1986 Jun 1;122(6):670-4. doi: 10.1001/archderm.1986.01660180076019, PMID 2940979.
References
1. Lee JJ, Downham 2nd TF. Furosemide-induced bullous pemphigoid: case report and review of literature. J Drugs Dermatol. 2006 Jun 1;5(6):562-4. PMID 16774111.
2. Cohen PR. Dyshidrosiform bullous pemphigoid: case reports and review. Cureus. 2020 Jan 11;12(1):e6630. doi: 10.7759/cureus.6630, PMID 32064205.
3. Patsatsi A, Vyzantiadis TA, Chrysomallis F, Devliotou?Panagiotidou D, Sotiriadis D. Medication history of a series of patients with bullous pemphigoid from northern Greece–observations and discussion. Int J Dermatol. 2009 Feb;48(2):132-5. doi: 10.1111/j.1365-4632.2009.03839.x, PMID 19200186.
4. Moro F, Fania L, Sinagra JLM, Salemme A, Di Zenzo G. Bullous pemphigoid: trigger and predisposing factors. Biomolecules. 2020;10(10):1432. doi: 10.3390/biom10101432, PMID 33050407.
5. Miyamoto D, Santi CG, Aoki V, Maruta CW. Bullous pemphigoid. An Bras Dermatol. 2019 May 9;94(2):133-46. doi: 10.1590/abd1806-4841.20199007, PMID 31090818.
6. Verheyden MJ, Bilgic A, Murrell DF. A systematic review of drug-induced pemphigoid. Actadermato-Venereol. 2020 Aug 17;100(15):1-9.
7. Asbrink E, Hovmark A. Clinical variations in bullous pemphigoid with respect to early symptoms. Acta Derm Venereol. 1981 Jan 1;61(5):417-21. doi: 10.2340/0001555561417421, PMID 6172930.
8. Bakker CV, Terra JB, Pas HH, Jonkman MF. Bullous pemphigoid as pruritus in the elderly: a common presentation. JAMA Dermatol. 2013 Aug 1;149(8):950-3. doi: 10.1001/jamadermatol.2013.756, PMID 23804286.
9. Bernard P, Antonicelli F. Bullous pemphigoid: a review of its diagnosis, associations and treatment. Am J Clin Dermatol. 2017 Aug;18(4):513-28. doi: 10.1007/s40257-017-0264-2, PMID 28247089.
10. Bakker CV, Terra JB, Pas HH, Jonkman MF. Bullous pemphigoid as pruritus in the elderly: a common presentation. JAMA Dermatol. 2013 Aug 1;149(8):950-3. doi: 10.1001/jamadermatol.2013.756, PMID 23804286.
11. Beutner EH, Lever WF, Witebsky E, Jordon R, Chertock B. Autoantibodies in pemphigus vulgaris: RESPONSE TO AN INTERCELLULAR SUBSTANCE OF EPIDERMIS. JAMA. 1965;192:682-8. doi: 10.1001/jama.1965.03080210026006, PMID 14280515.
12. Khumalo NP, Murrell DF, Wojnarowska F, Kirtschig G. A systematic review of treatments for bullous pemphigoid. Arch Dermatol. 2002 Mar 1;138(3):385-9. doi: 10.1001/archderm.138.3.385, PMID 11902990.
13. Berk MA, Lorincz AL. The treatment of bullous pemphigoid with tetracycline and niacinamide: a preliminary report. Arch Dermatol. 1986 Jun 1;122(6):670-4. doi: 10.1001/archderm.1986.01660180076019, PMID 2940979.
2. Cohen PR. Dyshidrosiform bullous pemphigoid: case reports and review. Cureus. 2020 Jan 11;12(1):e6630. doi: 10.7759/cureus.6630, PMID 32064205.
3. Patsatsi A, Vyzantiadis TA, Chrysomallis F, Devliotou?Panagiotidou D, Sotiriadis D. Medication history of a series of patients with bullous pemphigoid from northern Greece–observations and discussion. Int J Dermatol. 2009 Feb;48(2):132-5. doi: 10.1111/j.1365-4632.2009.03839.x, PMID 19200186.
4. Moro F, Fania L, Sinagra JLM, Salemme A, Di Zenzo G. Bullous pemphigoid: trigger and predisposing factors. Biomolecules. 2020;10(10):1432. doi: 10.3390/biom10101432, PMID 33050407.
5. Miyamoto D, Santi CG, Aoki V, Maruta CW. Bullous pemphigoid. An Bras Dermatol. 2019 May 9;94(2):133-46. doi: 10.1590/abd1806-4841.20199007, PMID 31090818.
6. Verheyden MJ, Bilgic A, Murrell DF. A systematic review of drug-induced pemphigoid. Actadermato-Venereol. 2020 Aug 17;100(15):1-9.
7. Asbrink E, Hovmark A. Clinical variations in bullous pemphigoid with respect to early symptoms. Acta Derm Venereol. 1981 Jan 1;61(5):417-21. doi: 10.2340/0001555561417421, PMID 6172930.
8. Bakker CV, Terra JB, Pas HH, Jonkman MF. Bullous pemphigoid as pruritus in the elderly: a common presentation. JAMA Dermatol. 2013 Aug 1;149(8):950-3. doi: 10.1001/jamadermatol.2013.756, PMID 23804286.
9. Bernard P, Antonicelli F. Bullous pemphigoid: a review of its diagnosis, associations and treatment. Am J Clin Dermatol. 2017 Aug;18(4):513-28. doi: 10.1007/s40257-017-0264-2, PMID 28247089.
10. Bakker CV, Terra JB, Pas HH, Jonkman MF. Bullous pemphigoid as pruritus in the elderly: a common presentation. JAMA Dermatol. 2013 Aug 1;149(8):950-3. doi: 10.1001/jamadermatol.2013.756, PMID 23804286.
11. Beutner EH, Lever WF, Witebsky E, Jordon R, Chertock B. Autoantibodies in pemphigus vulgaris: RESPONSE TO AN INTERCELLULAR SUBSTANCE OF EPIDERMIS. JAMA. 1965;192:682-8. doi: 10.1001/jama.1965.03080210026006, PMID 14280515.
12. Khumalo NP, Murrell DF, Wojnarowska F, Kirtschig G. A systematic review of treatments for bullous pemphigoid. Arch Dermatol. 2002 Mar 1;138(3):385-9. doi: 10.1001/archderm.138.3.385, PMID 11902990.
13. Berk MA, Lorincz AL. The treatment of bullous pemphigoid with tetracycline and niacinamide: a preliminary report. Arch Dermatol. 1986 Jun 1;122(6):670-4. doi: 10.1001/archderm.1986.01660180076019, PMID 2940979.