Formulation Development AND Evaluation OF ORAL Disintegrating Tablets OF Rizatriptan Benzoate

Abstract

In this work Rizatriptan benzoate oral disintegrating tablets were formulated utilizing compression approach. a thorough evaluation was conducted for stability dissolution, hardness, and disintegration time characteristics of various ODT formulations, interestingly friability tests came up with results lower than1%. In accordance with USPs 3-minutesdisintegration time requirement for ODTs all tablet formulations dissolved entirely within 1 minute. In addition, the optimized formulation dissolved more than 85%of the Rizatriptan benzoate, labeled content in under 15 minutes. The FTIR examination did not reveal any changes or between the excipients and the active component interaction. The use of superdisintegrants in ODT formulations is therefore a promising approach.