Date Log
Submitted
January 13, 2021
Published
January 13, 2021
Formulation Designing of Taste masked Dry Syrup of Ciprofloxacin HCL
Corresponding Author(s) : Dr. Sangeeta Asija
sangeetaasija@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 4 (2020): 2020 Volume - 8 Issue-4
Abstract
Taste masking and development of palatable dosage forms of bitter drugs constitutes the objective of many a research project in the field of pharmaceutical technology. Taste is an important factor in the development of dosage form. The problem of bitter and obnoxious taste of drug in pediatric patient can create a bad psychological effect on mind. The purpose of this research was to mask the intensely bitter taste of Ciprofloxacin is a broad spectrum antibiotic. It is extremely bitter taste resulting in poor patient’s compliance. The aim of present work was to prepare drug resin complex (DRC) using ion exchange resin (Kyron T114) for taste masking and formulate oral reconstituable dry syrup. Formulated ciprofloxacin reconstituable dry syrup has acceptable Drug Dissolution properties. In evaluating period of 7 days no significant change was observed in pH, sedimentation volume, specific gravityand drug content.From the results it concluded that effective taste masking of ciprofloxacin was achieve using Kyron T114 and successfully evaluated in reconstituable dry syrup.
Keywords
Ciprofloxacin
Sedimentation Volume
Ion exchange resin
Kyron T114
Drug Resin Complex (DRC),
Bhavana Salunke, Dr. Sangeeta Asija, Dr. Rajesh Asija, Anil Kumar Goyal, & Jitendra Kumar. (2021). Formulation Designing of Taste masked Dry Syrup of Ciprofloxacin HCL. International Journal of Allied Medical Sciences and Clinical Research, 8(4), 760–767. https://doi.org/10.61096/ijamscr.v8.iss4.2020.760-767
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References
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1. Suthar A.M. and Patel M. M; Ion Exchange Resin As An Imposing Method for Taste Masking: A Review. An International Journal of Pharmaceutical Sciences, 2018; 1(2): 7-11.
2. Sharma Deepak, Kumar Dinesh, Singh Mankaran, Singh Gurmeet, RathoreMahendra Singh; Taste Masking Technologies: A Novel Approach For The Improvement Of Organoleptic Property Of Pharmaceutical Active Substance. International Research Journal Of Pharmacy:2016; 3(4),2230-8407.
3. Jain N.K., Advances in Controlled and Novel drug Delivery,15th edition, CBS Publishers and Distributors, 2017: 290.
4. Parmar Pratik, Dr. Patel M.R., Dr.Patel K.R., Dr.Patel N.M.; A Review On Taste Masking Pediatric Dry Syrup. International Journal Of Universal Pharmacy And Bio Sciences, 2012: 2319-8141.
5. Jaysukh J Hirani1, Dhaval A Rathod1, Kantilal R Vadalia. Orally Disintegrating Tablets: A Review. Tropical J. Pharm. Res, April 2009; 8 (2): 161-172.
6. TejashSerasiya, ShaileshKoradia, SubhashVaghani, N.P. Jivanil. Design, Optimization and In vitro Evaluation of Orodispersible Tablets of Pheniramine Maleate. Int. J. Pharm. Re. & Development. 2009; l1 (10): 1-18.
7. A. Arunachalam, M. Karthikeyan, S. Ashutoshkumar, Kishore Konam, Pottabathulahari Prasad, S. Sethuraman, S. Manidipa. Fast dissolving drug delivery system: A review. J. Global Trends in Pharm. Sci. 2010; 1 (1): 92-110.
8. Peter H. Jones, Elizabeth K. Rowley, Arlene L. Weiss, Dorothy L. Bishop, Alexander H. C. Chun, Insoluble Erythromycin salts, Journal of Pharmaceutical Sciences, 58 (3), 2009, 337–339.
9. Puttewar T.Y. et al., Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin. Journal of King Saud University, 2010;22:page No.229-239.
10. Meena V. Pavane, Mrunal K. Shirsat, Avinash V. Dhobale, Deepak A. Joshi, Gunesh N. Dhembre, Parimal S. Ingale. Formulation, Development and Evaluation of Oral Reconstitutable Dry Syrup. IAJPS 2018, 05 (01), 483-491
11. Jasari T, Vuorio M, Ion exchange fibres and drug : anequilibiriumstucy, J Control release, 2001;70:219-229
12. Devarajan, Padma V, Gore SP. Melt in Mouth Tablets – Innovative Oral Drug Delivery Systems. Express Pharma Pulse 2000; 7(1) : 16-18.
13. Mahore J. G et al., Ion Exchange Resins: Pharmaceutical Applications and Recent Advancement. Journal of Scientific Research,2010:1(2): 8-11.
References
1. Suthar A.M. and Patel M. M; Ion Exchange Resin As An Imposing Method for Taste Masking: A Review. An International Journal of Pharmaceutical Sciences, 2018; 1(2): 7-11.
2. Sharma Deepak, Kumar Dinesh, Singh Mankaran, Singh Gurmeet, RathoreMahendra Singh; Taste Masking Technologies: A Novel Approach For The Improvement Of Organoleptic Property Of Pharmaceutical Active Substance. International Research Journal Of Pharmacy:2016; 3(4),2230-8407.
3. Jain N.K., Advances in Controlled and Novel drug Delivery,15th edition, CBS Publishers and Distributors, 2017: 290.
4. Parmar Pratik, Dr. Patel M.R., Dr.Patel K.R., Dr.Patel N.M.; A Review On Taste Masking Pediatric Dry Syrup. International Journal Of Universal Pharmacy And Bio Sciences, 2012: 2319-8141.
5. Jaysukh J Hirani1, Dhaval A Rathod1, Kantilal R Vadalia. Orally Disintegrating Tablets: A Review. Tropical J. Pharm. Res, April 2009; 8 (2): 161-172.
6. TejashSerasiya, ShaileshKoradia, SubhashVaghani, N.P. Jivanil. Design, Optimization and In vitro Evaluation of Orodispersible Tablets of Pheniramine Maleate. Int. J. Pharm. Re. & Development. 2009; l1 (10): 1-18.
7. A. Arunachalam, M. Karthikeyan, S. Ashutoshkumar, Kishore Konam, Pottabathulahari Prasad, S. Sethuraman, S. Manidipa. Fast dissolving drug delivery system: A review. J. Global Trends in Pharm. Sci. 2010; 1 (1): 92-110.
8. Peter H. Jones, Elizabeth K. Rowley, Arlene L. Weiss, Dorothy L. Bishop, Alexander H. C. Chun, Insoluble Erythromycin salts, Journal of Pharmaceutical Sciences, 58 (3), 2009, 337–339.
9. Puttewar T.Y. et al., Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin. Journal of King Saud University, 2010;22:page No.229-239.
10. Meena V. Pavane, Mrunal K. Shirsat, Avinash V. Dhobale, Deepak A. Joshi, Gunesh N. Dhembre, Parimal S. Ingale. Formulation, Development and Evaluation of Oral Reconstitutable Dry Syrup. IAJPS 2018, 05 (01), 483-491
11. Jasari T, Vuorio M, Ion exchange fibres and drug : anequilibiriumstucy, J Control release, 2001;70:219-229
12. Devarajan, Padma V, Gore SP. Melt in Mouth Tablets – Innovative Oral Drug Delivery Systems. Express Pharma Pulse 2000; 7(1) : 16-18.
13. Mahore J. G et al., Ion Exchange Resins: Pharmaceutical Applications and Recent Advancement. Journal of Scientific Research,2010:1(2): 8-11.
2. Sharma Deepak, Kumar Dinesh, Singh Mankaran, Singh Gurmeet, RathoreMahendra Singh; Taste Masking Technologies: A Novel Approach For The Improvement Of Organoleptic Property Of Pharmaceutical Active Substance. International Research Journal Of Pharmacy:2016; 3(4),2230-8407.
3. Jain N.K., Advances in Controlled and Novel drug Delivery,15th edition, CBS Publishers and Distributors, 2017: 290.
4. Parmar Pratik, Dr. Patel M.R., Dr.Patel K.R., Dr.Patel N.M.; A Review On Taste Masking Pediatric Dry Syrup. International Journal Of Universal Pharmacy And Bio Sciences, 2012: 2319-8141.
5. Jaysukh J Hirani1, Dhaval A Rathod1, Kantilal R Vadalia. Orally Disintegrating Tablets: A Review. Tropical J. Pharm. Res, April 2009; 8 (2): 161-172.
6. TejashSerasiya, ShaileshKoradia, SubhashVaghani, N.P. Jivanil. Design, Optimization and In vitro Evaluation of Orodispersible Tablets of Pheniramine Maleate. Int. J. Pharm. Re. & Development. 2009; l1 (10): 1-18.
7. A. Arunachalam, M. Karthikeyan, S. Ashutoshkumar, Kishore Konam, Pottabathulahari Prasad, S. Sethuraman, S. Manidipa. Fast dissolving drug delivery system: A review. J. Global Trends in Pharm. Sci. 2010; 1 (1): 92-110.
8. Peter H. Jones, Elizabeth K. Rowley, Arlene L. Weiss, Dorothy L. Bishop, Alexander H. C. Chun, Insoluble Erythromycin salts, Journal of Pharmaceutical Sciences, 58 (3), 2009, 337–339.
9. Puttewar T.Y. et al., Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin. Journal of King Saud University, 2010;22:page No.229-239.
10. Meena V. Pavane, Mrunal K. Shirsat, Avinash V. Dhobale, Deepak A. Joshi, Gunesh N. Dhembre, Parimal S. Ingale. Formulation, Development and Evaluation of Oral Reconstitutable Dry Syrup. IAJPS 2018, 05 (01), 483-491
11. Jasari T, Vuorio M, Ion exchange fibres and drug : anequilibiriumstucy, J Control release, 2001;70:219-229
12. Devarajan, Padma V, Gore SP. Melt in Mouth Tablets – Innovative Oral Drug Delivery Systems. Express Pharma Pulse 2000; 7(1) : 16-18.
13. Mahore J. G et al., Ion Exchange Resins: Pharmaceutical Applications and Recent Advancement. Journal of Scientific Research,2010:1(2): 8-11.