Copyright (c) 2020 Archana Kumari
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Mouth Melting Tablets an Overview
Corresponding Author(s) : Archana Kumari
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 2 (2020): 2020 Volume 8- Issue -2
Abstract
Mouth Melting tablets/ fast disintegrating tablets (FDTs) are receiving increased demand from last few decades and the field has become a very fast growing area in the pharmaceutical industry. After administration into the mouth, these tablets dissolve or disintegrate in the mouth without any additional water for easy administration of active pharmaceutical ingredients. These tablets readily dissolve or disintegrate in the saliva generally within seconds. Fast dissolving tablets/ mouth melting tablets have been formulated for pediatric, geriatric, bedridden patients and for active patients who are busy and traveling and may not have access to water. These tablet formulations provide a very good opportunity for product line extension in the many elderly persons will have difficulties in taking conventional oral dosage forms (viz., solutions, suspensions, tablets, and capsules) because of hand tremors and dysphasia.
Keywords
Mouth Melting Tablets
Fast disintegrating tablets
Super disintegrates
Direct compression
Wetting time
References
-
[1]. Bess W S, Kulkarni N, Ambike SH, Ramsay MP. Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1. US Patent 7067116. 2006.
[2]. Bhaskaran S, Narmada GV. Rapid dissolving tablets a novel dosage form. Indian Pharmacist. 1, 2002, 9–12.
[3]. B.S.Kuchekar., “Mouth dissolving tablets: A novel drug delivery system” Pharma times. 35, 2003, 7-9.
[4]. Bradoo R, Fast Dissolving Drug Delivery Systems, JAMA India. 4(10), 2001, 27-31.
[5]. Chang R, Guo X, Burnside BA, Couch R, Fast-dissolving tablets, Pharm. Tech. 24(6), 2000, 52-58.
[6]. CIMA LABS Inc. Easy-to-take orally disintegrating tablets. http://www.cimalabs.com/orally-disintegrating-tablets.
[7]. Elan Corporation, plc. Orally Disintegrating Tablets (ODT) - NanomeltTM.
http://www.elan.com/EDT/nanocrystal%5Ftechnology/orally_disintegrating_tablet.asp
[8]. http://www.phamacast.com/patents100/Yr2004/Ma y2004/051104/6733781_Fast dissolving 051104.html.
[9]. http://www.ispub.com/ostia/index.php?Xmlfilepath=jou nals/jjpharm/front.Xml.
[10]. Habib W, Khankari R, Hontz J, Fast-dissolving drug delivery systems critical review in therapeutics, Drug Carrier Systems, 17(1), 2000, 61-72.
[11]. Jaccard TT, Leyder J. Une nouvelle forme galenique: le lyoc. [A new galenic form: lyoc] Ann Pharm Fr. 43, 1985, 123–131. PMid: 4091454.
[12]. Koizumi KI, Watanabe Y, Morita K, Utoguchi N, Matsumoto M. New method for preparing high porosity rapidly saliva soluble compressed tablets using mannitol with camphor, a subliming material. Int J Pharm, 152, 1997, 127–131. Doi: 10.1016/S0378-5173(97)04924-7.
[13]. Kuchekar BS, Atul, Badhan C, Mahajan HS, Mouth dissolving tablets: A novel drug delivery system. Pharma Times, 35(1), 2003, 7-9.
[14]. Lafon L. Galenic form for oral administration and its method of preparation by lyophilization of an oil-in-water emulsion. US Patent 4616047, 1986.
[15]. L.H.Reddy, “Fast dissolving drug delivery systems: A review of the literature”, IJPS. 2002, 331-336.
[16]. L.Lachmann., The theory and practice of Industrial Pharmacy, 293-303.
[17]. Makino T, Yamada M, Kikuta JI. Fast-dissolving tablet and is production. US Patent 5, 720, 1998, 974.
[18]. Masaki K. Intrabuccally disintegrating preparation and production thereof. US Patent 5, 466, 1995, 464.
[19]. M.Slowson, “What to do when patients cannot swallow their medications", Pharm. Times ., 51, 1985, 90-96
[20]. Mizumoto T, Masuda Y, Fukui M. Intrabuccally dissolving compressed mouldings and production process thereof. US Patent 5,576,014. 1996, 19.
[21]. N.H. Indurwade, “Novel approach – Fast dissolving tablets”, Indian drugs, 39(8), 2002, 405-409.
[22]. Parakh SR, Gothoskar AV. A review of mouth dissolving tablet technologies. Pharm Technol. 27, 2003, 92-100.
[23]. Pebley WS, Jager NE, Thompson SJ. Rapidly disintegrating tablet. US Patient, 5, 298, 1994, 261.
[24]. Reddy.L.H , “Fast dissolving drug delivery systems: A review of the literature , IJPS. , 2002, 331-336.
[25]. R.K.Chang, “Fast-dissolving tablets”, Pharm Technology., 24(6), 2000, 52-58.
[26]. Shangraw R, Mitrevej A, Shah M. A new era of tablet disintegrants. Pharm Technology, 4, 1980, 49–57.
[27]. Shukla D, Chakraborty S, Singh S, Mishra B, Mouth Dissolving Tablets II: An Overview of Evaluation Techniques. Sci Pharm, 77, 2009, 327–341.
[28]. S.S. Biradar, “Fast dissolving drug delivery systems: a brief overview”, The Internet Journal of Pharmacology., 4(2), 2006.
[29]. Wehling F, Shuehle S. Base-coated acid particles and effervescent formulation incorporating same. US Patent 5, 503, 1996.
[30]. Wehling F, Shuehle S, Madamala N. Effervescent dosage form with microparticles. US Patent, 5(178), 1993, 878.
[31]. Wilson CG, Washington N, Peach J, Murray GR, Kennerley J, The behaviour of a fast-dissolving dosage form (Expidet) followed by gscintigraphy. Int J Pharm. 40, 1987, 119–123.
References
[1]. Bess W S, Kulkarni N, Ambike SH, Ramsay MP. Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1. US Patent 7067116. 2006.
[2]. Bhaskaran S, Narmada GV. Rapid dissolving tablets a novel dosage form. Indian Pharmacist. 1, 2002, 9–12.
[3]. B.S.Kuchekar., “Mouth dissolving tablets: A novel drug delivery system” Pharma times. 35, 2003, 7-9.
[4]. Bradoo R, Fast Dissolving Drug Delivery Systems, JAMA India. 4(10), 2001, 27-31.
[5]. Chang R, Guo X, Burnside BA, Couch R, Fast-dissolving tablets, Pharm. Tech. 24(6), 2000, 52-58.
[6]. CIMA LABS Inc. Easy-to-take orally disintegrating tablets. http://www.cimalabs.com/orally-disintegrating-tablets.
[7]. Elan Corporation, plc. Orally Disintegrating Tablets (ODT) - NanomeltTM.
http://www.elan.com/EDT/nanocrystal%5Ftechnology/orally_disintegrating_tablet.asp
[8]. http://www.phamacast.com/patents100/Yr2004/Ma y2004/051104/6733781_Fast dissolving 051104.html.
[9]. http://www.ispub.com/ostia/index.php?Xmlfilepath=jou nals/jjpharm/front.Xml.
[10]. Habib W, Khankari R, Hontz J, Fast-dissolving drug delivery systems critical review in therapeutics, Drug Carrier Systems, 17(1), 2000, 61-72.
[11]. Jaccard TT, Leyder J. Une nouvelle forme galenique: le lyoc. [A new galenic form: lyoc] Ann Pharm Fr. 43, 1985, 123–131. PMid: 4091454.
[12]. Koizumi KI, Watanabe Y, Morita K, Utoguchi N, Matsumoto M. New method for preparing high porosity rapidly saliva soluble compressed tablets using mannitol with camphor, a subliming material. Int J Pharm, 152, 1997, 127–131. Doi: 10.1016/S0378-5173(97)04924-7.
[13]. Kuchekar BS, Atul, Badhan C, Mahajan HS, Mouth dissolving tablets: A novel drug delivery system. Pharma Times, 35(1), 2003, 7-9.
[14]. Lafon L. Galenic form for oral administration and its method of preparation by lyophilization of an oil-in-water emulsion. US Patent 4616047, 1986.
[15]. L.H.Reddy, “Fast dissolving drug delivery systems: A review of the literature”, IJPS. 2002, 331-336.
[16]. L.Lachmann., The theory and practice of Industrial Pharmacy, 293-303.
[17]. Makino T, Yamada M, Kikuta JI. Fast-dissolving tablet and is production. US Patent 5, 720, 1998, 974.
[18]. Masaki K. Intrabuccally disintegrating preparation and production thereof. US Patent 5, 466, 1995, 464.
[19]. M.Slowson, “What to do when patients cannot swallow their medications", Pharm. Times ., 51, 1985, 90-96
[20]. Mizumoto T, Masuda Y, Fukui M. Intrabuccally dissolving compressed mouldings and production process thereof. US Patent 5,576,014. 1996, 19.
[21]. N.H. Indurwade, “Novel approach – Fast dissolving tablets”, Indian drugs, 39(8), 2002, 405-409.
[22]. Parakh SR, Gothoskar AV. A review of mouth dissolving tablet technologies. Pharm Technol. 27, 2003, 92-100.
[23]. Pebley WS, Jager NE, Thompson SJ. Rapidly disintegrating tablet. US Patient, 5, 298, 1994, 261.
[24]. Reddy.L.H , “Fast dissolving drug delivery systems: A review of the literature , IJPS. , 2002, 331-336.
[25]. R.K.Chang, “Fast-dissolving tablets”, Pharm Technology., 24(6), 2000, 52-58.
[26]. Shangraw R, Mitrevej A, Shah M. A new era of tablet disintegrants. Pharm Technology, 4, 1980, 49–57.
[27]. Shukla D, Chakraborty S, Singh S, Mishra B, Mouth Dissolving Tablets II: An Overview of Evaluation Techniques. Sci Pharm, 77, 2009, 327–341.
[28]. S.S. Biradar, “Fast dissolving drug delivery systems: a brief overview”, The Internet Journal of Pharmacology., 4(2), 2006.
[29]. Wehling F, Shuehle S. Base-coated acid particles and effervescent formulation incorporating same. US Patent 5, 503, 1996.
[30]. Wehling F, Shuehle S, Madamala N. Effervescent dosage form with microparticles. US Patent, 5(178), 1993, 878.
[31]. Wilson CG, Washington N, Peach J, Murray GR, Kennerley J, The behaviour of a fast-dissolving dosage form (Expidet) followed by gscintigraphy. Int J Pharm. 40, 1987, 119–123.
[2]. Bhaskaran S, Narmada GV. Rapid dissolving tablets a novel dosage form. Indian Pharmacist. 1, 2002, 9–12.
[3]. B.S.Kuchekar., “Mouth dissolving tablets: A novel drug delivery system” Pharma times. 35, 2003, 7-9.
[4]. Bradoo R, Fast Dissolving Drug Delivery Systems, JAMA India. 4(10), 2001, 27-31.
[5]. Chang R, Guo X, Burnside BA, Couch R, Fast-dissolving tablets, Pharm. Tech. 24(6), 2000, 52-58.
[6]. CIMA LABS Inc. Easy-to-take orally disintegrating tablets. http://www.cimalabs.com/orally-disintegrating-tablets.
[7]. Elan Corporation, plc. Orally Disintegrating Tablets (ODT) - NanomeltTM.
http://www.elan.com/EDT/nanocrystal%5Ftechnology/orally_disintegrating_tablet.asp
[8]. http://www.phamacast.com/patents100/Yr2004/Ma y2004/051104/6733781_Fast dissolving 051104.html.
[9]. http://www.ispub.com/ostia/index.php?Xmlfilepath=jou nals/jjpharm/front.Xml.
[10]. Habib W, Khankari R, Hontz J, Fast-dissolving drug delivery systems critical review in therapeutics, Drug Carrier Systems, 17(1), 2000, 61-72.
[11]. Jaccard TT, Leyder J. Une nouvelle forme galenique: le lyoc. [A new galenic form: lyoc] Ann Pharm Fr. 43, 1985, 123–131. PMid: 4091454.
[12]. Koizumi KI, Watanabe Y, Morita K, Utoguchi N, Matsumoto M. New method for preparing high porosity rapidly saliva soluble compressed tablets using mannitol with camphor, a subliming material. Int J Pharm, 152, 1997, 127–131. Doi: 10.1016/S0378-5173(97)04924-7.
[13]. Kuchekar BS, Atul, Badhan C, Mahajan HS, Mouth dissolving tablets: A novel drug delivery system. Pharma Times, 35(1), 2003, 7-9.
[14]. Lafon L. Galenic form for oral administration and its method of preparation by lyophilization of an oil-in-water emulsion. US Patent 4616047, 1986.
[15]. L.H.Reddy, “Fast dissolving drug delivery systems: A review of the literature”, IJPS. 2002, 331-336.
[16]. L.Lachmann., The theory and practice of Industrial Pharmacy, 293-303.
[17]. Makino T, Yamada M, Kikuta JI. Fast-dissolving tablet and is production. US Patent 5, 720, 1998, 974.
[18]. Masaki K. Intrabuccally disintegrating preparation and production thereof. US Patent 5, 466, 1995, 464.
[19]. M.Slowson, “What to do when patients cannot swallow their medications", Pharm. Times ., 51, 1985, 90-96
[20]. Mizumoto T, Masuda Y, Fukui M. Intrabuccally dissolving compressed mouldings and production process thereof. US Patent 5,576,014. 1996, 19.
[21]. N.H. Indurwade, “Novel approach – Fast dissolving tablets”, Indian drugs, 39(8), 2002, 405-409.
[22]. Parakh SR, Gothoskar AV. A review of mouth dissolving tablet technologies. Pharm Technol. 27, 2003, 92-100.
[23]. Pebley WS, Jager NE, Thompson SJ. Rapidly disintegrating tablet. US Patient, 5, 298, 1994, 261.
[24]. Reddy.L.H , “Fast dissolving drug delivery systems: A review of the literature , IJPS. , 2002, 331-336.
[25]. R.K.Chang, “Fast-dissolving tablets”, Pharm Technology., 24(6), 2000, 52-58.
[26]. Shangraw R, Mitrevej A, Shah M. A new era of tablet disintegrants. Pharm Technology, 4, 1980, 49–57.
[27]. Shukla D, Chakraborty S, Singh S, Mishra B, Mouth Dissolving Tablets II: An Overview of Evaluation Techniques. Sci Pharm, 77, 2009, 327–341.
[28]. S.S. Biradar, “Fast dissolving drug delivery systems: a brief overview”, The Internet Journal of Pharmacology., 4(2), 2006.
[29]. Wehling F, Shuehle S. Base-coated acid particles and effervescent formulation incorporating same. US Patent 5, 503, 1996.
[30]. Wehling F, Shuehle S, Madamala N. Effervescent dosage form with microparticles. US Patent, 5(178), 1993, 878.
[31]. Wilson CG, Washington N, Peach J, Murray GR, Kennerley J, The behaviour of a fast-dissolving dosage form (Expidet) followed by gscintigraphy. Int J Pharm. 40, 1987, 119–123.