Copyright (c) 2020 Srishti Jain
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
A Review on Orodisintegrating Tablets
Corresponding Author(s) : Srishti Jain
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 2 (2020): 2020 Volume 8- Issue -2
Abstract
Orally disintegrating tablets (ODTs) as well as critical issues during evaluation of ODTs such as bioequivalence and challenges and limitations of ODTs and finally present and the future of ODTs. ODTs have received ever- increasing demand and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water. When ODTs are put on tongue they disintegrate instantaneously, releasing the drug which dissolve or disperses in the saliva. Some drugs are absorbed from the mouth, pharynx and esophagus as the saliva passes down in to the stomach. In such cases, bioavailability of a drug is significantly greater than those observed from conventional tablet dosage form. The advantages of mouth dissolving dosage form are increasingly being recognized in both, industry and academia. Their growing importance has been underlined recently when European Pharmacopoeia adopted the term “Orodispersible Tablet” as tablet that is to be place in the mouth where it disperses rapidly before swallowing. ODTs have some challenges but solutions to overcome these challenges were shown in this paper.
Keywords
Taste masking
Orally disintegrating
Orodispersible
Tablets
Fast
Advantages
References
-
[1]. Sagar T, Gayke A; Review on Taste masking approaches and Evaluation of Taste Masking. IJPS 2012, 1895 - 1907.
[2]. Aditi Tripathi, Taste Masking: A Novel Approach for Bitter and Obnoxious Drugs, Journal of Pharmaceutical Science and Bioscience Research: 1(3), 2011, 136-142.
[3]. Vijay D. Wagh, Taste Masking Methods and Techniques in Oral Pharmaceuticals: Current Perspectives, Journal of Pharmacy Research 2(6), 2009, 1049-1054.
[4]. Vinod M. Sonawane, An update of taste masking methods and evaluation techniques, Scholars Research Library, Der Pharmacia Lettre, 2(6), 2010, 1- 15.
[5]. Sidharth Puri, Review Article- Taste Masking: A Novel Approch for Bitter and Obnoxious Drugs, International Journal of Biopharmaceutical & Toxicological Research, 1(1), 2011, 47-56.
[6]. Joseph P. Reo, Evaluation of a taste sensor instrument (electronic tongue) for use in formulation development, International Journal of Pharmaceutics 367, 2009, 65ñ72.
[7]. K Gowthamarajan, Pop the Pills without Bitterness Taste-Masking Technologies for Bitter Drugs General Article, Resonance 2004, 25-32.
[8]. Arvind K. Bansal, Trends in Pharmaceutical Taste Masking Technologies: A Patent Review, Recent Patents on Drug Delivery & Formulation 3, 2009, 26- 39, © 2009 Bentham Science Publishers Ltd.
[9]. Sanjay Daharwal, Taste masking method for bitter drug and tasteless dispersible tablet: an overview, 1-7.
[10]. Gupta A.K., Practical Approaches for Taste Masking of Bitter Drug: A Review.
[11]. S. T. Birhade, Preparation and Evaluation of Cyclodextrin Based Binary Systems for Taste Masking, International Journal of Pharmaceutical Sciences and Drug Research 2(3), 2010, 199-203.
[12]. Mizumoto T, Masuda Y, Takeshi Y, Estuo Y, Katsuhide T. Formulation design of a novel fast- disintegrating tablet. Int J Pharm, 306(1- 2), 2005, 83–90.
[13]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 3(6), 2001, 58-61.
[14]. Hanawa T, Watanabe A, Tsuchiya T, Ikoma R, Hidaka M, Sugihara M. New Oral dosage form for elderly patients: Preparation and characterization of silk fibroin gel. Chem Pharm Bull, 43(2), 1995, 284-288.
[15]. European Directorate for quality of Medicines. Pharmaeuropa. 10(4), 1998, 547.
http://www.pheur.org. Accessed 2007.
[16]. Ghosh TK, Chatterjee DJ, Pfister WR. Quick dissolving oral dosage forms: Scientific and regulatory considerations from a clinical pharmacology and biopharmaceutical perspective. In: Ghosh TK and Pfister WR (Eds). Drug Delivery to the Oral Cavity: Molecules to Market. NY, USA: CRC Press, 2005, 337-356.
[17]. Mallet L. Caring for the Elderly Patient. J. Am. Pharm. Assoc, 36(11), 1996, 628-635.
[18]. Aguilar-Díaz JE, García-Montoya E, Suñe-Negre JM, Pérez-Lozano P, Miñarro M, et al. Predicting orally disintegrating tablets formulations of ibuprophen tablets:An application of the new SeDeM-ODT expert system. Eur J Pharm Biopharm 80, 2012, 638-48.
[19]. Fu Y, Yan S, Jeong SH, Kimura S, Park K Orally fast disintegrating tablets: developments, technologies, taste masking and clinical studies. Crit Rev Ther Drug Carrier Syst 21, 2004, 433-76.
[20]. Rangasamy M. Oral disintegrating tablets: A future compaction. Drug Invent Today 1, 2009, 61-5.
[21]. Reddy LH, Ghosh BR. Fast dissolving drug delivery systems: A review of the literature. Ind J Pharm Sci, 64(4), 2002, 331-336
[22]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 2001; 3(6): 58-61.
[23]. Aurora J, Pathak V. Oral disintegrating technologies: Oral disintegrating dosage forms: An overview. Drug Deliv Technol, 5(3), 2005, 50-54.
[24]. Hamilton EL, Luts EM. Advanced Orally disintegrating tablets bring significant benefits to patients and product life cycle. Drug Deliv Technol, 5(1), 2005, 34-37.
[25]. Habib W, Khankari R, Honts J. Fast dissolving drug delivery systems. Crt Rev Ther Drug Carrier Syst, 17(1), 2000, 61-72.
[26]. Habib W, Khankari R, Hontz J Fast dissolving drug delivery systems: Critical review in therapeutics. Drug Carrier Systems 17, 2002, 61- 72.
[27]. Kaur T, Gill B, Kumar S, Gupta GD. Mouth Dissolving Tablets: A Novel Approach to Drug Delivery. Int J Curr Pharm Res 3, 2011, 1-7.
[28]. Lies MC, Atherton AD, Copping NM. Freeze-dried dosage forms and methods for preparing same. US Patent 5, 188, 825, 1993.
[29]. Reddy M, Babu S, Harshita B, Sravya R Conventional and Patented Technologies In Oral Dispersible Tablets: A Review. J Chem Pharm Sci 6, 2013, 286-92.
[30]. Sugihara M, Hidaka M, Saitou A. Discriminatory features of dosage form and package. Jpn J Hosp Pharm, 12, 1986, 322-328.
[31]. Sharma S. New generation of tablet: fast dissolving tablet. http://www.pharmainfo.net. Accessed 2008.
[32]. Kuchekar BS, Bhise SB, Arumugam V. Design of fast dissolving tablets. Ind J Pharm Edu, 35, 2001, 150-152.
References
[1]. Sagar T, Gayke A; Review on Taste masking approaches and Evaluation of Taste Masking. IJPS 2012, 1895 - 1907.
[2]. Aditi Tripathi, Taste Masking: A Novel Approach for Bitter and Obnoxious Drugs, Journal of Pharmaceutical Science and Bioscience Research: 1(3), 2011, 136-142.
[3]. Vijay D. Wagh, Taste Masking Methods and Techniques in Oral Pharmaceuticals: Current Perspectives, Journal of Pharmacy Research 2(6), 2009, 1049-1054.
[4]. Vinod M. Sonawane, An update of taste masking methods and evaluation techniques, Scholars Research Library, Der Pharmacia Lettre, 2(6), 2010, 1- 15.
[5]. Sidharth Puri, Review Article- Taste Masking: A Novel Approch for Bitter and Obnoxious Drugs, International Journal of Biopharmaceutical & Toxicological Research, 1(1), 2011, 47-56.
[6]. Joseph P. Reo, Evaluation of a taste sensor instrument (electronic tongue) for use in formulation development, International Journal of Pharmaceutics 367, 2009, 65ñ72.
[7]. K Gowthamarajan, Pop the Pills without Bitterness Taste-Masking Technologies for Bitter Drugs General Article, Resonance 2004, 25-32.
[8]. Arvind K. Bansal, Trends in Pharmaceutical Taste Masking Technologies: A Patent Review, Recent Patents on Drug Delivery & Formulation 3, 2009, 26- 39, © 2009 Bentham Science Publishers Ltd.
[9]. Sanjay Daharwal, Taste masking method for bitter drug and tasteless dispersible tablet: an overview, 1-7.
[10]. Gupta A.K., Practical Approaches for Taste Masking of Bitter Drug: A Review.
[11]. S. T. Birhade, Preparation and Evaluation of Cyclodextrin Based Binary Systems for Taste Masking, International Journal of Pharmaceutical Sciences and Drug Research 2(3), 2010, 199-203.
[12]. Mizumoto T, Masuda Y, Takeshi Y, Estuo Y, Katsuhide T. Formulation design of a novel fast- disintegrating tablet. Int J Pharm, 306(1- 2), 2005, 83–90.
[13]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 3(6), 2001, 58-61.
[14]. Hanawa T, Watanabe A, Tsuchiya T, Ikoma R, Hidaka M, Sugihara M. New Oral dosage form for elderly patients: Preparation and characterization of silk fibroin gel. Chem Pharm Bull, 43(2), 1995, 284-288.
[15]. European Directorate for quality of Medicines. Pharmaeuropa. 10(4), 1998, 547.
http://www.pheur.org. Accessed 2007.
[16]. Ghosh TK, Chatterjee DJ, Pfister WR. Quick dissolving oral dosage forms: Scientific and regulatory considerations from a clinical pharmacology and biopharmaceutical perspective. In: Ghosh TK and Pfister WR (Eds). Drug Delivery to the Oral Cavity: Molecules to Market. NY, USA: CRC Press, 2005, 337-356.
[17]. Mallet L. Caring for the Elderly Patient. J. Am. Pharm. Assoc, 36(11), 1996, 628-635.
[18]. Aguilar-Díaz JE, García-Montoya E, Suñe-Negre JM, Pérez-Lozano P, Miñarro M, et al. Predicting orally disintegrating tablets formulations of ibuprophen tablets:An application of the new SeDeM-ODT expert system. Eur J Pharm Biopharm 80, 2012, 638-48.
[19]. Fu Y, Yan S, Jeong SH, Kimura S, Park K Orally fast disintegrating tablets: developments, technologies, taste masking and clinical studies. Crit Rev Ther Drug Carrier Syst 21, 2004, 433-76.
[20]. Rangasamy M. Oral disintegrating tablets: A future compaction. Drug Invent Today 1, 2009, 61-5.
[21]. Reddy LH, Ghosh BR. Fast dissolving drug delivery systems: A review of the literature. Ind J Pharm Sci, 64(4), 2002, 331-336
[22]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 2001; 3(6): 58-61.
[23]. Aurora J, Pathak V. Oral disintegrating technologies: Oral disintegrating dosage forms: An overview. Drug Deliv Technol, 5(3), 2005, 50-54.
[24]. Hamilton EL, Luts EM. Advanced Orally disintegrating tablets bring significant benefits to patients and product life cycle. Drug Deliv Technol, 5(1), 2005, 34-37.
[25]. Habib W, Khankari R, Honts J. Fast dissolving drug delivery systems. Crt Rev Ther Drug Carrier Syst, 17(1), 2000, 61-72.
[26]. Habib W, Khankari R, Hontz J Fast dissolving drug delivery systems: Critical review in therapeutics. Drug Carrier Systems 17, 2002, 61- 72.
[27]. Kaur T, Gill B, Kumar S, Gupta GD. Mouth Dissolving Tablets: A Novel Approach to Drug Delivery. Int J Curr Pharm Res 3, 2011, 1-7.
[28]. Lies MC, Atherton AD, Copping NM. Freeze-dried dosage forms and methods for preparing same. US Patent 5, 188, 825, 1993.
[29]. Reddy M, Babu S, Harshita B, Sravya R Conventional and Patented Technologies In Oral Dispersible Tablets: A Review. J Chem Pharm Sci 6, 2013, 286-92.
[30]. Sugihara M, Hidaka M, Saitou A. Discriminatory features of dosage form and package. Jpn J Hosp Pharm, 12, 1986, 322-328.
[31]. Sharma S. New generation of tablet: fast dissolving tablet. http://www.pharmainfo.net. Accessed 2008.
[32]. Kuchekar BS, Bhise SB, Arumugam V. Design of fast dissolving tablets. Ind J Pharm Edu, 35, 2001, 150-152.
[2]. Aditi Tripathi, Taste Masking: A Novel Approach for Bitter and Obnoxious Drugs, Journal of Pharmaceutical Science and Bioscience Research: 1(3), 2011, 136-142.
[3]. Vijay D. Wagh, Taste Masking Methods and Techniques in Oral Pharmaceuticals: Current Perspectives, Journal of Pharmacy Research 2(6), 2009, 1049-1054.
[4]. Vinod M. Sonawane, An update of taste masking methods and evaluation techniques, Scholars Research Library, Der Pharmacia Lettre, 2(6), 2010, 1- 15.
[5]. Sidharth Puri, Review Article- Taste Masking: A Novel Approch for Bitter and Obnoxious Drugs, International Journal of Biopharmaceutical & Toxicological Research, 1(1), 2011, 47-56.
[6]. Joseph P. Reo, Evaluation of a taste sensor instrument (electronic tongue) for use in formulation development, International Journal of Pharmaceutics 367, 2009, 65ñ72.
[7]. K Gowthamarajan, Pop the Pills without Bitterness Taste-Masking Technologies for Bitter Drugs General Article, Resonance 2004, 25-32.
[8]. Arvind K. Bansal, Trends in Pharmaceutical Taste Masking Technologies: A Patent Review, Recent Patents on Drug Delivery & Formulation 3, 2009, 26- 39, © 2009 Bentham Science Publishers Ltd.
[9]. Sanjay Daharwal, Taste masking method for bitter drug and tasteless dispersible tablet: an overview, 1-7.
[10]. Gupta A.K., Practical Approaches for Taste Masking of Bitter Drug: A Review.
[11]. S. T. Birhade, Preparation and Evaluation of Cyclodextrin Based Binary Systems for Taste Masking, International Journal of Pharmaceutical Sciences and Drug Research 2(3), 2010, 199-203.
[12]. Mizumoto T, Masuda Y, Takeshi Y, Estuo Y, Katsuhide T. Formulation design of a novel fast- disintegrating tablet. Int J Pharm, 306(1- 2), 2005, 83–90.
[13]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 3(6), 2001, 58-61.
[14]. Hanawa T, Watanabe A, Tsuchiya T, Ikoma R, Hidaka M, Sugihara M. New Oral dosage form for elderly patients: Preparation and characterization of silk fibroin gel. Chem Pharm Bull, 43(2), 1995, 284-288.
[15]. European Directorate for quality of Medicines. Pharmaeuropa. 10(4), 1998, 547.
http://www.pheur.org. Accessed 2007.
[16]. Ghosh TK, Chatterjee DJ, Pfister WR. Quick dissolving oral dosage forms: Scientific and regulatory considerations from a clinical pharmacology and biopharmaceutical perspective. In: Ghosh TK and Pfister WR (Eds). Drug Delivery to the Oral Cavity: Molecules to Market. NY, USA: CRC Press, 2005, 337-356.
[17]. Mallet L. Caring for the Elderly Patient. J. Am. Pharm. Assoc, 36(11), 1996, 628-635.
[18]. Aguilar-Díaz JE, García-Montoya E, Suñe-Negre JM, Pérez-Lozano P, Miñarro M, et al. Predicting orally disintegrating tablets formulations of ibuprophen tablets:An application of the new SeDeM-ODT expert system. Eur J Pharm Biopharm 80, 2012, 638-48.
[19]. Fu Y, Yan S, Jeong SH, Kimura S, Park K Orally fast disintegrating tablets: developments, technologies, taste masking and clinical studies. Crit Rev Ther Drug Carrier Syst 21, 2004, 433-76.
[20]. Rangasamy M. Oral disintegrating tablets: A future compaction. Drug Invent Today 1, 2009, 61-5.
[21]. Reddy LH, Ghosh BR. Fast dissolving drug delivery systems: A review of the literature. Ind J Pharm Sci, 64(4), 2002, 331-336
[22]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 2001; 3(6): 58-61.
[23]. Aurora J, Pathak V. Oral disintegrating technologies: Oral disintegrating dosage forms: An overview. Drug Deliv Technol, 5(3), 2005, 50-54.
[24]. Hamilton EL, Luts EM. Advanced Orally disintegrating tablets bring significant benefits to patients and product life cycle. Drug Deliv Technol, 5(1), 2005, 34-37.
[25]. Habib W, Khankari R, Honts J. Fast dissolving drug delivery systems. Crt Rev Ther Drug Carrier Syst, 17(1), 2000, 61-72.
[26]. Habib W, Khankari R, Hontz J Fast dissolving drug delivery systems: Critical review in therapeutics. Drug Carrier Systems 17, 2002, 61- 72.
[27]. Kaur T, Gill B, Kumar S, Gupta GD. Mouth Dissolving Tablets: A Novel Approach to Drug Delivery. Int J Curr Pharm Res 3, 2011, 1-7.
[28]. Lies MC, Atherton AD, Copping NM. Freeze-dried dosage forms and methods for preparing same. US Patent 5, 188, 825, 1993.
[29]. Reddy M, Babu S, Harshita B, Sravya R Conventional and Patented Technologies In Oral Dispersible Tablets: A Review. J Chem Pharm Sci 6, 2013, 286-92.
[30]. Sugihara M, Hidaka M, Saitou A. Discriminatory features of dosage form and package. Jpn J Hosp Pharm, 12, 1986, 322-328.
[31]. Sharma S. New generation of tablet: fast dissolving tablet. http://www.pharmainfo.net. Accessed 2008.
[32]. Kuchekar BS, Bhise SB, Arumugam V. Design of fast dissolving tablets. Ind J Pharm Edu, 35, 2001, 150-152.