A Review on Fibrodysplasia Ossificans Progressiva

Abstract

It is a very rare inherited connective tissue disease which involves the abnormal development of bone in the body in the areas where bone is not normally present (heterotopic ossification), such as the skeletal muscles, tendons and ligaments. The other names for this disease are munchmeyer disease, stone man disease. In this disease what happen are mainly the soft connective tissues and skeletal muscles changes into bone. The process is known as metamorphosis. The main problem with this disease is there is no proper cure or treatment; this is some kind of rare and severe disease. There is no other medical condition known till now in which one organ system changes into another organ system. This is more seen in the children's first it starts in the body parts like neck, shoulder regions, and then it moves down the body and then move into the limbs. The main clinical feature in the Fibrodysplasiaossificansprogressiva is that they are born with malformed big toes. The main hallmark feature of this disease is hallux valgus (It is a progressive foot deformity in which the first metatarsophalangeal joint is affected) .one feature that helps to differentiate from other muscle and bone problems is the abnormality of the big toes. The patients with this disease can hardly live up to 40 years. The increased levels of alkaline phosphatase indicate this disease. This main problem is that there is no proper treatment or cure for this rare disease.