Research on mouth dissolving tablet atorvastatin calcium using natural super disintegrants

Abstract

The Purpose of the present research was to prepare Mouth Dissolving Tablet of Atorvastatin Calcium using natural superdisintegrant i.e. Plantago Ovata and Guar gum with the objective of patient compliance and the reduced onset of action due first pass metabolism. Tablet were prepared by direct compression method. The powder mixtures prepared were subjected to both pre and post compression evaluation parameters like micromeritics properties, tablet hardness, friability, wetting time, disintegration time and in vitro drug release. The results of micromeritics studies revealed that all formulations were of acceptable to good flow ability. On the basis of invitro studies F3 containing 16mg of Plantago Ovata was best formulation.