Carbamazepine Induced Steven Johnson Syndrome: a Case Report
Corresponding Author(s) : SreeNagavalli K
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 2 No. 2 (2014): 2014 Volume 2- Issue -2
Abstract
Drugs are the most common cause that induces Steven Johnson syndrome (SJS) and includes antiepileptic drugs, antiretroviral drugs, anti-tuberculosis drugs, Sulphonamides, fluoroquinolones, penicillins, non-Steroidal anti-inflammatory drugs, Multivitamins. The genetic markers are also the cause for carbamazepine induced Steven Johnson Syndrome. In our study, the antiepileptic drug (Carbamazepine) is the cause for Steven Johnson Syndrome. A female patient aged 25 years came to the hospital with the complaints of bubbling over the skin and all over the body with papillary vesicles associated with pain and irritation, fever, myalgia, and nausea. The patient is known case of Phenytoin induced Steven Johnson Syndrome. In this case the patient developed the Steven Johnson Syndrome approximately after one month after starting the carbamazepine.By the withdrawal of the drug, the condition of the patient was improved.
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[1] Man CB, Kwan P, Baum L, Yu E, Lau KM, Cheng AS, Ng MH. Association between HLA-B?1502 Allele and Antiepileptic Drug-Induced Cutaneous Reactions in Han Chinese. Epilepsia 2007; 48(5):1015–1018.
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[5] Santosh et al., A Case Report on Carbamazepine Induced Steven Johnson Syndrome. World J Pharm Sci 2013; 1(1): 19-20.
[6] Rannakoe J Lehloenya et al., Approaching Cutaneous Adverse Drug Reactions. Lesotho Medical Association Journal 2011; 9 (1): 13-14.
[7] Santosh et al., A Case Report on Carbamazepine Induced Steven Johnson Syndrome. World J Pharm Sci 2013; 1(1): 19-20.
[8] Araki Y, Sotozono C, Inatomi T, et al. Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset. Am J Ophthalmol 2009; 147:1004 1011.
References
[2] RannakoeLehloenya. Management of Stevens - Johnson syndrome and Toxic Epidermal Necrolysis. Current Allergy & Clinical Immunology. 2007; 20 (3): 124-128.
[3] The CHMP Pharmacovigilance Working Party (PhVWP)plenary meeting. 19- 21 September 2011. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2011/09/news_detail_001338.jsp&murl=menus/news_and_events/news_and_events.jsp&mid=WC0b01ac058004d5c1.
[4] Kandil et al. Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report. Radiation Oncology 2010, 5:49
[5] Santosh et al., A Case Report on Carbamazepine Induced Steven Johnson Syndrome. World J Pharm Sci 2013; 1(1): 19-20.
[6] Rannakoe J Lehloenya et al., Approaching Cutaneous Adverse Drug Reactions. Lesotho Medical Association Journal 2011; 9 (1): 13-14.
[7] Santosh et al., A Case Report on Carbamazepine Induced Steven Johnson Syndrome. World J Pharm Sci 2013; 1(1): 19-20.
[8] Araki Y, Sotozono C, Inatomi T, et al. Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset. Am J Ophthalmol 2009; 147:1004 1011.