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Monoherbal Formulation Development for Laxative Activity
Corresponding Author(s) : Manimaran Sellappan
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 2 No. 2 (2014): 2014 Volume 2- Issue -2
Abstract
The Ayurvedic Pharmacopoeia specifically approves flaxseed as a poultice for boils externally and demulcent or laxative internally. In this study monoherbal formulation development for laxative activity of flaxseed was undertaken. The plantLinumusitatissimumhasshowed higher percentage of total ash as well as alcohol soluble extractive values. The aqueous extract of Linumusitatissimumwas prepared by using pilot scale extraction plant and spray drying unit. The qualitative phytochemical studies reveal the presence of amino acids, carbohydrates, vitamins and proteins. From the available literatures it was found that Linumusitatissimum contains more number of amino acids. The formulated tablets showed acceptable pharmacopoeial limits and complies with specifications for thickness, hardness, friability and weight variation. The formulation has showed better laxative activity indicating additive property of the combined phytoconstituents of the plant.
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[1] Manning AP, Heaton KW, Harvey RF,Uglow P(1997). Wheat fiber and irritable bowel syndrome, Lancet 1, 417-418.
[2] DerMarderosian, A., & Beutler, J. A (2010). Flax. The review of natural products: The most complete source of natural product information. United States of America: Wolters Kluwer Health.Sixth edit., pp. 551–559.
[3] Akhtar, S., Ismail, T., & Riaz, M (2013). Flaxseed-A miraculous defense against some critical maladies. Pakistan Journal of Pharmaceutical Sciences, 26(1), 199–208.
[4] Toure, A., & Xueming, X (2010). Flaxseed lignans: Source, biosynthesis, metabolism, antioxidant activity, bio-active components, and health benefits. Comprehensive Reviews in Food Science and Food Safety, 9, 261–269.
[5] Rabetafika, H. N., Remoortel, V. Van, Danthine, S., Paquot, M., & Blecker, C (2011).
Flaxseed proteins: Food uses and health benefits. International Journal of Food Science &
Technology, 46, 221–228.
[6] Karnic CR(1994). Pharmacopoeial standards of herbal plants, Vol. 1-2. Delhi: SriSatguru Publications., Vol. 1; 228-229; Vol. 2; 55.
[7] The Wealth of India (1998). A dictionary of Indian raw materials and industrials products, Publications and information directorate. CSIR. New Delhi: I; 219.
[8] Mukherjee, PK (2002). Quality control of Herbal drugs. Business Horizons, New Delhi.; 187 – 191.
[9] Dave Oomah B, Mazza G (2001). Optimization of a spray drying process for flaxseed gum. International Journal of Food Science & Technology, 36 (2); 135-143.
[10] Lachman and Liberman (1991). Theory and Practice of Industrial Pharmacy. Lea &Fabiger, Philadelphia, 3: 120-145.
[11] Copper.j. Gunn.Carter SJ (1986). Powder flow and compaction in tutorial pharmacy. II edi, CBS Publishers and Distributers, New Delhi, India, 211-233.
[12] Indian Pharmacopoeia (1996). Ministry of Health & family Welfare, Govt. of India, The Controller of Publications, New Delhi; A - 89.
[13] OECD (2002). Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the OECD, guidelines for the testing of chemicals organisation for economical co-operation and development, Paris.
[14] Capasso F, Mascolo N, Autore G and Romano V (1986). Laxatives and the production of autocoids by rat colon. J. Pharm. Pharmacol, 13 : 627-629.
[15] Ghosh MN (2011). Fundamentals of Experimental Pharmacology. 5th edition. Kolkata: Hilton & Company
[16] Prashanta Kumar Deb, Lakshman Das, RanjibGhosh, RajkumarDebnath, TejendraBhakta (2013). Evaluation of laxative and cardiotonic activity of solanumindicumlinn. Fruits. J Pharm Phytother,1:3, 11 – 14.
References
[2] DerMarderosian, A., & Beutler, J. A (2010). Flax. The review of natural products: The most complete source of natural product information. United States of America: Wolters Kluwer Health.Sixth edit., pp. 551–559.
[3] Akhtar, S., Ismail, T., & Riaz, M (2013). Flaxseed-A miraculous defense against some critical maladies. Pakistan Journal of Pharmaceutical Sciences, 26(1), 199–208.
[4] Toure, A., & Xueming, X (2010). Flaxseed lignans: Source, biosynthesis, metabolism, antioxidant activity, bio-active components, and health benefits. Comprehensive Reviews in Food Science and Food Safety, 9, 261–269.
[5] Rabetafika, H. N., Remoortel, V. Van, Danthine, S., Paquot, M., & Blecker, C (2011).
Flaxseed proteins: Food uses and health benefits. International Journal of Food Science &
Technology, 46, 221–228.
[6] Karnic CR(1994). Pharmacopoeial standards of herbal plants, Vol. 1-2. Delhi: SriSatguru Publications., Vol. 1; 228-229; Vol. 2; 55.
[7] The Wealth of India (1998). A dictionary of Indian raw materials and industrials products, Publications and information directorate. CSIR. New Delhi: I; 219.
[8] Mukherjee, PK (2002). Quality control of Herbal drugs. Business Horizons, New Delhi.; 187 – 191.
[9] Dave Oomah B, Mazza G (2001). Optimization of a spray drying process for flaxseed gum. International Journal of Food Science & Technology, 36 (2); 135-143.
[10] Lachman and Liberman (1991). Theory and Practice of Industrial Pharmacy. Lea &Fabiger, Philadelphia, 3: 120-145.
[11] Copper.j. Gunn.Carter SJ (1986). Powder flow and compaction in tutorial pharmacy. II edi, CBS Publishers and Distributers, New Delhi, India, 211-233.
[12] Indian Pharmacopoeia (1996). Ministry of Health & family Welfare, Govt. of India, The Controller of Publications, New Delhi; A - 89.
[13] OECD (2002). Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the OECD, guidelines for the testing of chemicals organisation for economical co-operation and development, Paris.
[14] Capasso F, Mascolo N, Autore G and Romano V (1986). Laxatives and the production of autocoids by rat colon. J. Pharm. Pharmacol, 13 : 627-629.
[15] Ghosh MN (2011). Fundamentals of Experimental Pharmacology. 5th edition. Kolkata: Hilton & Company
[16] Prashanta Kumar Deb, Lakshman Das, RanjibGhosh, RajkumarDebnath, TejendraBhakta (2013). Evaluation of laxative and cardiotonic activity of solanumindicumlinn. Fruits. J Pharm Phytother,1:3, 11 – 14.