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Evaluation of Anti Diabetic Potential of Leaves of Nelumbo Nucifera in Streptozotocin Induced Diabetic Rats
Corresponding Author(s) : Nallani Venkata Rama Rao
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 1 No. 1 (2013): 2013 Volume 1- Issue -1
Abstract
Nelumbo nucifera Gaertn. (Nymphaeaceae), also known as sacred lotus, is a well known medicinal plant. Nelumbo nucifera (family Nymphaeaceae) are free floating plants.The methanolic extract of Nelumbo nucifera leaves was obtained by soxhlet extraction apparatus. The extract was subjected to preliminary phytochemical screening by using standard procedures.The toxicity studies and dose fixation were carried out by using OECD 425 guideline. According to OECD 425 guideline toxicity study no toxic symptoms were observed up to dose 2000 mg/kg.The anti diabetic effect of Nelumbo nucifera leaf methanolic extract given in streptozotocin induced diabetic rats. Oral administration of methanolic extract for 15 days in diabetic mice exhibits highly significant (P < 0.01) antidiabetic activity and also alters the body weight significantly . The data were analyzed using analysis of variance followed by Dunnett's test.The observations confirm that methanolic extract of NELUMBO NUCIFERA leaf and stem has antidiabetic activity due to presence of alkaloids,aminoacids, saponins, glycosides, triterpenoid, vitamins etc There is a need of further investigation to isolate and identify the principle chemical constituents for its anti diabetic property.
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[1]Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes. Diabetes Care 2004;27:1047-53.
[2]Georg P, Ludvik B. Lipids and diabetes. J Clin Basic Cardiol 2000;3:159-62.
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[10]Khandelwal KR. Practical Pharmacognosy techniques and experiments. 14 th ed. Pune: Nirali Prakashan; 2005. p. 150-3.
[11]Kokate CK. Practical Pharmacognosy. 4 th ed. Delhi: Vallabh Prakashan; 1997. p108-11.
[12]OECD guidelines for the testing of chemicals (Acute oral toxicity - up and down procedure), Cited 2008 Mar 20]; Available from: http://www.oecd.org [last accessed on 2006 Mar 23].
[13]Noor A, Gunasekaran S, Manickam AS, Vijayalakshmi MA, Antidiabetic activity of aloe vera and histology of organs in streptozotocin induced diabetic rats, Curr Sci ;2008;94:1070-5.
[14]Kaleem M, Medha P, Ahmed QU, Asif M, Bano B, Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats, Singapore Med J 2008;49; 800-4
References
[2]Georg P, Ludvik B. Lipids and diabetes. J Clin Basic Cardiol 2000;3:159-62.
[3]Bain SC, Kelly AM, Mijovic CH, Barnett AH. Genetic factors in the pathogenesis of Type 1 diabetes. In: Pickup JC, Williams G, editors. Textbook of Diabetes. Oxford: Blackwell Scientific Publications; 1996. p. 15.1-16.1.
[4]Scoppola A, Montecchi FR, Menzinger G, Lala A. Urinary mevalonate excretion rate in type 2 diabetes: Role of metabolic control. Atherosclerosis 2001;156:357-61.
[5]Betteridge DJ. Diabetic dyslipidemia. Am J Med 1994;96:S25-31.
[6]Goodman and Gilman?s. The Pharmacological basis of therapeutics. 11 th ed. New Delhi: McGraw-Hill, Medical Publishing Division; 2006. p. 933.
[7]Qiner Y, Zmarzty S. Flora of China. Available from: http://www.EFloras.org . St. Louis, MO & Harvard University Herbaria, Cambridge, MA: Missouri Botanical Garden Press; 2007. p. 118-21.
[8]Ahmad J, Wizarat K, Shamsuddin KM, Zaman A, Connlly JD. Jangomolide, a novel limonoid from Flacourtia jangomas. Phytochemistry 1984;23:1269-70.
[9]Kirthikar KR, Basu BD. Indian Medicinal Plants. 2 nd ed. (1) Dehra Dun, India: Bishen Singh Mahendra Pal Singh; 1993. p. 220.
[10]Khandelwal KR. Practical Pharmacognosy techniques and experiments. 14 th ed. Pune: Nirali Prakashan; 2005. p. 150-3.
[11]Kokate CK. Practical Pharmacognosy. 4 th ed. Delhi: Vallabh Prakashan; 1997. p108-11.
[12]OECD guidelines for the testing of chemicals (Acute oral toxicity - up and down procedure), Cited 2008 Mar 20]; Available from: http://www.oecd.org [last accessed on 2006 Mar 23].
[13]Noor A, Gunasekaran S, Manickam AS, Vijayalakshmi MA, Antidiabetic activity of aloe vera and histology of organs in streptozotocin induced diabetic rats, Curr Sci ;2008;94:1070-5.
[14]Kaleem M, Medha P, Ahmed QU, Asif M, Bano B, Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats, Singapore Med J 2008;49; 800-4