A study of comparison of mean platelet volume in diabetic and nondiabetic individuals

Abstract

Introduction

Platelets with larger volume have more activity compared to smaller ones. Increased platelet activity was considered as one of the pathogenic mechanism for complications of diabetes. Thus Mean platelet volume (MPV) can be utilized as a marker for diabetic complications.

Aim

1. To determine the difference in MPV in Diabetic and non-diabetic individuals and


2. To correlate MPV with fasting blood glucose, Post prandial blood glucose and HbA1C.

Materials and methods

A cross - sectional study with 150 diabetics and 150 nondiabetic individuals attending Medicine op at tertiary   hospital were included. Patients with anemia, malignancies and onantiplatelet were excluded from the study. All the patients underwent complete clinical examination and FBS, PPBS, HbA1C, Platelet count and MPV were estimated and the results were analyzed using SPSS 20 version

Results

MPV was significantly higher in diabetic individuals and MPV was higher in diabetic patients with complications than in patients without complications. MPV has no significant association with BMI, Duration of diabetes, FBS, PPBS, HbA1C.

Conclusion

Mean platelet volume was significantly (p <0.01) higher in diabetic patients. MPV can be used as marker for diabetic complications .