A study on drug prescription pattern of antihypertensives in a tertiary care hospital
Corresponding Author(s) : Anjali T
anjalit86@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 4 No. 3 (2016): 2016 Volume 4- Issue -3
Abstract
Background and Aim: Hypertension is an important public health challenge because of the associated morbidity and mortality caused by cardiovascular diseases and the cost to the society. Methods and Results: The study group consisted of four hundred patients who attended the outpatient department of Medicine at Medical College, Thiruvananthapuram. At base line, patient demographics, family history which includes previous history of hypertension and any other co-morbidity were assessed using the preform. The cost of antihypertensives has to be determined by using the information available from the Kerala Medical Services Corporation Limited (KMSCL), and National Pharmacy Pricing Authority (NPPA). The salient findings of the study are: 60.5% were females and 39.5% were males. Majority of the patients were under the age group of 60-69 (31.5%), 70- 79 (25%) and 50-59 (22.5%). 50.8% patients were treated with monotherapy and 49.3% patients were treated with combination therapy. During the cost analysis, the mean cost of antihypertensive was found to be Rs.0.30 in monotherapy and in combination therapy it was found to be Rs.1.2. Conclusion: The present study represents the current prescribing trend for antihypertensive agents and it highlights certain shortcomings in the existing prescribing practice.
Keywords
Hypertension,
Antihypertensives,
Monotherapy,
Combination therapy
1.
Anjali T. A study on drug prescription pattern of antihypertensives in a tertiary care hospital. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2020 Aug. 6 [cited 2025 Oct. 26];4(3):355-61. Available from: https://ijamscr.com/ijamscr/article/view/280
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References
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Rajeev Gupta, V.P Gupta; Hypertension epidemiology in India: lessons from Jaipur heart watch, 97, 2009, 3, 10.
[2]. Shahina P.T, Revi Kumar K.G, Krishnan R, Jaleel V.A, Shini V. K, The impact of pharmacist interventions on
49.3
50.8
monotherapy
polytherapy
Anjali T et al / Int. J. of Allied Med. Sci. and Clin. Research Vol-4(3) 2016 [355-361]
361
quality of life in patients with hypertension, 5(3), 2010.
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[11]. M C S Wong, J Y Jiang, A T Lam, H Fung, S Griffiths and S W Mercer et al. Patterns of antihypertensive prescribing, discontinuation and switching among a Hong Kong Chineese population from over one million prescription research letter. J. Hypertension: 2008, 56-60.
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[13]. Rodgers A, Lawes C, Mac Mahon S et al. Reducing the global burden of blood pressure related cardiovascular diseases. Journal of Hypertension: 18(1), 2000, S3-S6.
[14]. Doggrell, Sheil A et al. Is amlodipine the best initial monotherapy for hypertension? Expert opinion on pharmacotherapy 7(6), 2006, 829-832.
[15]. M S Kochar, D Trottier, G Kotecki, M Forbes et al. Sequential monotherapy of hypertension. Clinical pharmacology: 34(12), 1994, 1173-1176.
[16]. Heinrich Holzgreve et al. Combination versus monotherapy as initial treatment in hypertension. 28 (8), 725-732.
References
Rajeev Gupta, V.P Gupta; Hypertension epidemiology in India: lessons from Jaipur heart watch, 97, 2009, 3, 10.
[2]. Shahina P.T, Revi Kumar K.G, Krishnan R, Jaleel V.A, Shini V. K, The impact of pharmacist interventions on
49.3
50.8
monotherapy
polytherapy
Anjali T et al / Int. J. of Allied Med. Sci. and Clin. Research Vol-4(3) 2016 [355-361]
361
quality of life in patients with hypertension, 5(3), 2010.
[3]. Bethesda. Seventh report of Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. National heart, lung, and blood institute, National high blood pressure education programme, 2003.
[4]. Carter BL. Highlights of the sixth report of Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. Am. J. Health syst pharm. 55, 382, 1998.
[5]. Burt VL, Cutler J A, Higgins M et al. Trends in the prevalence, awareness, treatment and control of hypertension in the adult US population: data from the health examination surveys, 1960 to 1991. Hypertension: 1995, 60.
[6]. Pickering TG. Optimal blood pressure levels. Am. J. Hypertension 11, 1998, 877.
[7]. Neil S. Skolnik M D. Combination antihypertensive drugs; Recommendations for use. Am. Fam physician 61, 2000, 3049-56.
[8]. Materson BJ, Red DJ, Cushman WC, Massie BG, Fries ED, Kochar MS et al. Single drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. New England Journal of Medicine 328, 1993, 914-21
[9]. Aram V. Chobanian, George L. Bakris, Henry P. Black. Seventh report of Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. Hypertension.42, 2003, 1206-1252.
[10]. Dipiro JT, Talbert RL, Yee GC, Mateke GR, Well BG, Posey LM. Pharmacotherapy- A pathophysiologic approach. Sixth edition. New York, Mc Graw Hill professions divisions; 2005, 194-197.
[11]. M C S Wong, J Y Jiang, A T Lam, H Fung, S Griffiths and S W Mercer et al. Patterns of antihypertensive prescribing, discontinuation and switching among a Hong Kong Chineese population from over one million prescription research letter. J. Hypertension: 2008, 56-60.
[12]. Kearney P. Whelton M, Reynold K, Muntner P, Whelton P.K, Hc J et al. Global burden of hypertension: Analysis of worldwide data. Lancet; 365, 2005, 217-223.
[13]. Rodgers A, Lawes C, Mac Mahon S et al. Reducing the global burden of blood pressure related cardiovascular diseases. Journal of Hypertension: 18(1), 2000, S3-S6.
[14]. Doggrell, Sheil A et al. Is amlodipine the best initial monotherapy for hypertension? Expert opinion on pharmacotherapy 7(6), 2006, 829-832.
[15]. M S Kochar, D Trottier, G Kotecki, M Forbes et al. Sequential monotherapy of hypertension. Clinical pharmacology: 34(12), 1994, 1173-1176.
[16]. Heinrich Holzgreve et al. Combination versus monotherapy as initial treatment in hypertension. 28 (8), 725-732.
[2]. Shahina P.T, Revi Kumar K.G, Krishnan R, Jaleel V.A, Shini V. K, The impact of pharmacist interventions on
49.3
50.8
monotherapy
polytherapy
Anjali T et al / Int. J. of Allied Med. Sci. and Clin. Research Vol-4(3) 2016 [355-361]
361
quality of life in patients with hypertension, 5(3), 2010.
[3]. Bethesda. Seventh report of Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. National heart, lung, and blood institute, National high blood pressure education programme, 2003.
[4]. Carter BL. Highlights of the sixth report of Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. Am. J. Health syst pharm. 55, 382, 1998.
[5]. Burt VL, Cutler J A, Higgins M et al. Trends in the prevalence, awareness, treatment and control of hypertension in the adult US population: data from the health examination surveys, 1960 to 1991. Hypertension: 1995, 60.
[6]. Pickering TG. Optimal blood pressure levels. Am. J. Hypertension 11, 1998, 877.
[7]. Neil S. Skolnik M D. Combination antihypertensive drugs; Recommendations for use. Am. Fam physician 61, 2000, 3049-56.
[8]. Materson BJ, Red DJ, Cushman WC, Massie BG, Fries ED, Kochar MS et al. Single drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. New England Journal of Medicine 328, 1993, 914-21
[9]. Aram V. Chobanian, George L. Bakris, Henry P. Black. Seventh report of Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. Hypertension.42, 2003, 1206-1252.
[10]. Dipiro JT, Talbert RL, Yee GC, Mateke GR, Well BG, Posey LM. Pharmacotherapy- A pathophysiologic approach. Sixth edition. New York, Mc Graw Hill professions divisions; 2005, 194-197.
[11]. M C S Wong, J Y Jiang, A T Lam, H Fung, S Griffiths and S W Mercer et al. Patterns of antihypertensive prescribing, discontinuation and switching among a Hong Kong Chineese population from over one million prescription research letter. J. Hypertension: 2008, 56-60.
[12]. Kearney P. Whelton M, Reynold K, Muntner P, Whelton P.K, Hc J et al. Global burden of hypertension: Analysis of worldwide data. Lancet; 365, 2005, 217-223.
[13]. Rodgers A, Lawes C, Mac Mahon S et al. Reducing the global burden of blood pressure related cardiovascular diseases. Journal of Hypertension: 18(1), 2000, S3-S6.
[14]. Doggrell, Sheil A et al. Is amlodipine the best initial monotherapy for hypertension? Expert opinion on pharmacotherapy 7(6), 2006, 829-832.
[15]. M S Kochar, D Trottier, G Kotecki, M Forbes et al. Sequential monotherapy of hypertension. Clinical pharmacology: 34(12), 1994, 1173-1176.
[16]. Heinrich Holzgreve et al. Combination versus monotherapy as initial treatment in hypertension. 28 (8), 725-732.