A Systematic Review on Nano Formulations of Natural Products Used in Inflammation and Wound Healing

Abstract

Inflammation and wound healing are complex biological processes essential for tissue repair and defense against injury and infection. Natural products derived from plants, animals, and microorganisms have long been utilized in traditional medicine systems due to their anti-inflammatory, antioxidant, and regenerative properties. However, the therapeutic application of many natural compounds is limited by poor solubility, low bioavailability, instability, and rapid degradation at the site of action. Nanotechnology has emerged as a powerful approach to overcome these limitations by enabling the development of nanoformulations such as nanoparticles, liposomes, nanoemulsions, hydrogels, and polymeric nanocarriers. These systems enhance drug penetration, provide controlled and sustained release, protect bioactive constituents, and improve therapeutic efficacy. This systematic review highlights the historical development, current status, mechanisms, principles, classification, applications, and advantages of nanoformulated natural products in inflammation and wound healing. The integration of nanotechnology with natural therapeutics offers innovative solutions for chronic wounds, burns, diabetic ulcers, and inflammatory disorders, positioning nano-enabled natural products as a promising strategy in modern regenerative medicine.