COMPARATIVE In-Vitro ANTIDIABETIC EVALUATION OF ETHANOLIC AND CHLOROFORM ALBIZIA AMARA LEAF EXTRACTS

Abstract

Background:Diabetes is a major global health concern, impacting more than 540 million persons globally. Type 2 diabetes mellitus is the most common variety, and it is mostly associated with poor eating habits, sedentary lifestyles, and rising obesity rates, particularly in developing nations. The rising prevalence of this metabolic condition raises serious health concerns and highlights the urgent need for safer and more effective antidiabetic medications. In recent years, plants used in traditional medicine have received interest as possible sources of new antidiabetic chemicals. Albizia amara, a plant often used in herbal medicine, has been shown to contain a number of bioactive components that may contribute to its therapeutic effects.

Aim:The present research sought to assess and compare the antidiabetic effects of ethanolic and chloroform leaf extracts of Albizia amara. The study also looked at how solvent polarity affected phytochemical extraction and biological activity.

Method:The phytochemical content of both extracts was investigated using qualitative tests to identify important bioactive chemicals such as flavonoids, alkaloids, tannins, glycosides, and saponins. The antidiabetic potential of the extracts was then investigated using a typical experimental diabetes model, with voglibose serving as the reference medication. Blood glucose levels were measured to determine the effectiveness of each extract in managing hyperglycemia.

Result:Phytochemical screening revealed the presence of many bioactive chemicals in both extracts, indicating potential therapeutic value. The ethanolic extract reduced blood glucose levels more than the chloroform extract, implying that higher-polarity solvents may improve the extraction of active components responsible for antidiabetic actions.

Conclusion:The data show that Albiziaamara has strong antidiabetic potential, which supports its traditional use in diabetes management. The greater efficacy of the ethanolic extract emphasizes the significance of solvent choice in phytochemical extraction. Further research into chemical isolation, characterization, and mechanistic investigations is needed to fully understand Albiziaamara'smedicinal potential and involvement in diabetes treatment.