INFLAMMATORY MARKERS OF SEPSIS IN PEDIATRICS CASES

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Vol. 13 No. 4 (2025): 2025 Volume -13 - Issue 4

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October 29, 2025
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INFLAMMATORY MARKERS OF SEPSIS IN PEDIATRICS CASES

https://doi.org/10.61096/ijamscr.v13.iss4.2025.676-682
Mahadevaiah V
MBBS, MD. Department of Pediatrics, Chandramma Dayananda Sagar Institute of Medical Education and Research. Bengaluru, Karnataka, India
Srinath Meera. K
MBBS, MD. Department of Biochemistry, Ramaiah Medical College and Hospital. Bengaluru, Karnataka, India.

Corresponding Author(s) : Srinath Meera. K

meerasrinath@hotmail.com

International Journal of Allied Medical Sciences and Clinical Research, Vol. 13 No. 4 (2025): 2025 Volume -13 - Issue 4

Abstract

Background: Sepsis is currently one of the important problems in medicine due to its complexity from pathophysiologic, clinical and therapeutic perspectives. The study was aimed to assess the levels of inflammatory markers and evaluate their performance in predicting severity and outcome in pediatric sepsis cases. Methods:  The study included 84 cases admitted to pediatric intensive care unit with suspicion of sepsis based on International Pediatric Sepsis Consensus Criteria for sepsis (2005). Blood sample from cases were assessed for serum presepsin, procalcitonin, C-reactive protein in addition to routine investigations in sepsis including blood culture at the time of admission. Results: The study sample comprised 47 cases with sepsis and 37 cases with severe sepsis. The mean values of serum presepsin, procalcitonin and C-reactive protein in severe sepsis were significantly higher in comparison to sepsis cases with p value <0.01. The rise in serum presepsin was six fold in severe sepsis as compared to its rise in sepsis cases. However, increase in C-reactive protein was two folds in severe sepsis cases as compared to sepsis cases.  The area under the curve (AUC) of serum presepsin (0.814) was highest followed by C-reactive protein (0.749) and procalcitonin (0.718) in predicting the severity. With serum presepsin value greater than 650 pg. /ml, had 80% positive predictive value and 76% negative predictive value. Serum presepsin showed higher specificity (95 % against 55% and 49%) and positive predictive value (55 % against 17% and 15%) than procalcitonin and C-reactive protein respectively, in predicting mortality.  Interpretation and Conclusion: Serum presepsin was found to be better inflammatory marker of sepsis than procalcitonin and C-reactive protein in predicting both severity and mortality in these cases.         

Keywords

inflammatory markers presepsin procalcitonin sepsis
1.
V M, Meera. K S. INFLAMMATORY MARKERS OF SEPSIS IN PEDIATRICS CASES. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2025 Oct. 29 [cited 2025 Dec. 16];13(4):676-82. Available from: https://ijamscr.com/ijamscr/article/view/1689
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