Nanotechnology in Endodontics: A Contemporary Review

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Vol. 13 No. 3 (2025): 2025 Volume -13 - Issue 3

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August 4, 2025
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Nanotechnology in Endodontics: A Contemporary Review

Nivea
Post Graduate Resident, Department of Conservative Dentistry & Endodontics, Faculty of Dental Sciences, King George’s Medical University, Lucknow, U.P., India
Pragya Pandey
Additional Professor, Department of Conservative Dentistry & Endodontics, Faculty of Dental Sciences, King George’s Medical University, Lucknow, U.P., India
Dr. Promila Verma
Head and Professor, Department of Conservative Dentistry & Endodontics, Faculty of Dental Sciences, King George’s Medical University, Lucknow, U.P., India
Ramesh Bharti
Professor, Department of Conservative Dentistry & Endodontics, Faculty of Dental Sciences, King George’s Medical University, Lucknow, U.P., India

Corresponding Author(s) : Nivea

sethinivea@gmail.com

International Journal of Allied Medical Sciences and Clinical Research, Vol. 13 No. 3 (2025): 2025 Volume -13 - Issue 3

Abstract

Nanotechnology is revolutionizing the field of endodontics by providing advanced solutions to persistent clinical challenges, particularly in root canal disinfection, material enhancement, and regenerative procedures. Conventional endodontic techniques, though effective, often fail to fully eradicate microbial biofilms due to complex root canal anatomy. Nanoparticles, with their unique physicochemical properties and nanoscale dimensions (1–100 nm), offer improved penetration, increased surface reactivity, and targeted antimicrobial action. Silver nanoparticles (AgNPs), chitosan nanoparticles, and zinc oxide nanoparticles (ZnO NPs) exhibit broad-spectrum antibacterial activity by disrupting biofilms, generating reactive oxygen species (ROS), and improving therapeutic outcomes. Nano-enhanced irrigants and medicaments, such as nano-silver solutions and modified triple antibiotic pastes, demonstrate superior antimicrobial efficacy and reduced cytotoxicity. Furthermore, nanoparticles integrated into obturation materials enhance sealing ability, biocompatibility, and mechanical properties, while nano-hydroxyapatite promotes remineralization. In regenerative endodontics, nanofibrous scaffolds and nanoparticle-based drug delivery systems facilitate stem cell proliferation and controlled growth factor release. Diagnostic applications include quantum dots and magnetic nanoparticles, improving imaging precision and treatment monitoring. Despite promising benefits, challenges such as cytotoxicity, lack of standardized protocols, and limited clinical trials remain. Continued research and interdisciplinary collaboration are essential to translate nanotechnology into routine endodontic practice.

Keywords

Nanotechnology Nanoparticles Endodontics Root Canal Disinfection Regenerative Endodontics Nano-irrigants Nano-materials
1.
Nivea, Pragya Pandey, Dr. Promila Verma, Ramesh Bharti. Nanotechnology in Endodontics: A Contemporary Review. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2025 Aug. 4 [cited 2025 Sep. 20];13(3):490-3. Available from: https://ijamscr.com/ijamscr/article/view/1655
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