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Formulation development and in vitro evaluation of terbutaline floating tablets
Corresponding Author(s) : Ch. Akhila
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 12 No. 4 (2024): 2024 Volume -12 - Issue 4
Abstract
The present study outlines a systematic approach for designing and development of Terbutaline floatingtablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Terbutaline haveshown sustained release thereby proper duration of action at a particular site and are designed to prolong thegastric residence time after oral administration. Different formulations were formulated by using direct compression method. A floating drug delivery system (FDDS) was developed by using sodium bicarbonate asgas-forming agent and HPMC E5, Eudragit RLPO and Sodium carboxy methylcellulose as polymers. The prepared tablets wereevaluated in terms of their physical characteristics, precompression parameters, in vitro release and buoyancylag time. The results of the in vitrorelease studies showed that the optimized formulation (T7) could sustaindrug release for 12 hrs by using Sodium carboxy methylcellulose in the concentration of 5mg. The in vitro drug release followed zero order kinetics.
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- Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery system. Expert Opin Drug Deliv, 2006; 3(2): 217- 33.
- 2. Garg R, Gupta GD. Progress in controlled gastroretentive delivery systems. Trop. J Pharm Res, 2008; 7(3): 1055-66.
- Rouge N, Allemann E, Gex-Fabry M, Balant L, Cole ET, Buri P, Doelker E. Comparative pharmacokinetic study of a floating multiple-unit capsule, a high density multipleunit capsule and an immediate-release tablet containing 25 mg atenolol. Pharm Acta Helbetiae, 1998; 73: 81-7.
- Streubel A, Siepmann J, Bodmeier R. Multiple unit Gastroretentive drug delivery: a new preparation method for low density microparticles. J Microencapsul, 2003; 20: 329-47.
- Goole J, Vanderbist F, Aruighi K. Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms. Int J Pharm, 2007; 334: 35-41.
- Shrma S, Pawar A. Low density multiparticulate system for pulsatile release of meloxicam. Int J Pharm, 2006; 313: 150-58.
- Santus G, Lazzarini G, Bottoni G, Sandefer EP, Page RC, Doll WJ, Ryo UY, Digenis GA. An in vitro- in vivo investigation of oral bioadhesive controlled release furosemide formulations. Eur J Pharm Biopharm 1997; 44: 39-52.
- Klausner EA, Lavy E, Friedman M, Hoffman A. Expandable gastroretentive dosage forms. J Control Release 2003; 90: 143-62.
- Deshpande AA, Shah N, Rhodes CT, Malik W. Development of a novel controlled-release system for gastric retention. Pharm Res 1997; 14: 815-19.
- Park K. Enzyme-digestible swelling as platforms for longterm oral drug delivery: synthesis and characterization. Biomaterials 1988; 9: 435.
- Fujimori J, Machida Y, Nagai T. Preparation of a magneticallyresponsive tablet and configuration of its gastric residence in beagle dogs. STP Pharma Sci 1994; 4: 425-30.
- S.U. Zate, P.I. Kothawade, G.H. Mahale, K.P. Kapse, S.P. Anantwar. GastroretentiveBioadhesive Drug Delivery System: A Review. International Journal of PharmTech Research Res. 2(2); 2010: 1227-1235.
- Desai S, Bolton S. A floating controlled release drug delivery system: in vitro- in vivo evaluation. Pharm Res. 1993;10:1321-1325. PubMed DOI: 10.1023/A:1018921830385
- Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release. 2000;63:235-259. PubMed DOI: 10.1016/S0168-3659(99)00204-7
- Arrora S, Ali J, Khar RK, Baboota S. Floatng drug delivery systems: A review. AAPS Pharm Sci Tech 2005; 6(3): 372-90.
References
Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery system. Expert Opin Drug Deliv, 2006; 3(2): 217- 33.
2. Garg R, Gupta GD. Progress in controlled gastroretentive delivery systems. Trop. J Pharm Res, 2008; 7(3): 1055-66.
Rouge N, Allemann E, Gex-Fabry M, Balant L, Cole ET, Buri P, Doelker E. Comparative pharmacokinetic study of a floating multiple-unit capsule, a high density multipleunit capsule and an immediate-release tablet containing 25 mg atenolol. Pharm Acta Helbetiae, 1998; 73: 81-7.
Streubel A, Siepmann J, Bodmeier R. Multiple unit Gastroretentive drug delivery: a new preparation method for low density microparticles. J Microencapsul, 2003; 20: 329-47.
Goole J, Vanderbist F, Aruighi K. Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms. Int J Pharm, 2007; 334: 35-41.
Shrma S, Pawar A. Low density multiparticulate system for pulsatile release of meloxicam. Int J Pharm, 2006; 313: 150-58.
Santus G, Lazzarini G, Bottoni G, Sandefer EP, Page RC, Doll WJ, Ryo UY, Digenis GA. An in vitro- in vivo investigation of oral bioadhesive controlled release furosemide formulations. Eur J Pharm Biopharm 1997; 44: 39-52.
Klausner EA, Lavy E, Friedman M, Hoffman A. Expandable gastroretentive dosage forms. J Control Release 2003; 90: 143-62.
Deshpande AA, Shah N, Rhodes CT, Malik W. Development of a novel controlled-release system for gastric retention. Pharm Res 1997; 14: 815-19.
Park K. Enzyme-digestible swelling as platforms for longterm oral drug delivery: synthesis and characterization. Biomaterials 1988; 9: 435.
Fujimori J, Machida Y, Nagai T. Preparation of a magneticallyresponsive tablet and configuration of its gastric residence in beagle dogs. STP Pharma Sci 1994; 4: 425-30.
S.U. Zate, P.I. Kothawade, G.H. Mahale, K.P. Kapse, S.P. Anantwar. GastroretentiveBioadhesive Drug Delivery System: A Review. International Journal of PharmTech Research Res. 2(2); 2010: 1227-1235.
Desai S, Bolton S. A floating controlled release drug delivery system: in vitro- in vivo evaluation. Pharm Res. 1993;10:1321-1325. PubMed DOI: 10.1023/A:1018921830385
Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release. 2000;63:235-259. PubMed DOI: 10.1016/S0168-3659(99)00204-7
Arrora S, Ali J, Khar RK, Baboota S. Floatng drug delivery systems: A review. AAPS Pharm Sci Tech 2005; 6(3): 372-90.