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Design And Development Of Curcumin Loaded Nanorobots For Targeting Colon Cancer
Corresponding Author(s) : Ubaidulla Uthumansha
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 12 No. 4 (2024): 2024 Volume -12 - Issue 4
Abstract
Colorectal cancer is one of the most widespread tumors worldwide, and it is considered to be the second leading cause of death among cancer groups. Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat colorectal cancer. Targeted drug delivery systems are essential for improving the effectiveness of cancer treatment while minimizing side effects. The development of smart curcumin nanorobots for targeting colon cancer cells is a significant advancement in this field. By utilizing green synthesis of magnetite, coating curcumin nanoparticles, and incorporating them into smart nanolegs, a motile and targeted drug delivery system has been successfully created.
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- Li J, Ávila BEF de, Gao W, Zhang L, Wang J. Micro/nanorobots for Biomedicine: Delivery, surgery, sensing, and detoxification. Science Robotics. 2017;2(4). doi:10.1126/scirobotics.aam6431
- Xu Z, Wu Z, Yuan M, Chen Y, Ge W, Xu Q. Versatile magnetic hydrogel soft capsule microrobots for targeted delivery. iScience. 2023;26(5). doi:10.1016/j.isci.2023.106727
- Deshmukh AR, Gupta A, Kim BS. Ultrasound Assisted Green Synthesis of Silver and Iron Oxide Nanoparticles Using Fenugreek Seed Extract and Their Enhanced Antibacterial and Antioxidant Activities. BioMed Research International. 2019;2019. doi:10.1155/2019/1714358
- Ghafarzadegan R, Yaghoobi M, Momtaz S, Ashouri N, Ghiaci-Yekta M, Hajiaghaee R. Process optimization for green synthesis of iron nanoparticles by extract of fenugreek (Trigonella foenum-graecum L.) seeds. Journal of Medicinal Plants. 2022;21(81). doi:10.52547/jmp.21.81.22
- Li P, Pu S, Lin C, et al. Curcumin selectively induces colon cancer cell apoptosis and S cell cycle arrest by regulates Rb/E2F/p53 pathway. Journal of Molecular Structure. 2022;1263. doi:10.1016/j.molstruc.2022.133180
- Kanwal Q, Ahmed M, Hamza M, et al. Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies. RSC Advances. 2023;13(32). doi:10.1039/d3ra01432k
- Shakoor IF, Pamunuwa GK, Karunaratne DN. Efficacy of alginate and chickpea protein polymeric matrices in encapsulating curcumin for improved stability, sustained release and bioaccessibility. Food Hydrocolloids for Health. 2023;3. doi:10.1016/j.fhfh.2023.100119
- Sinha P, Udhumansha U, Rathnam G, Ganesh M, Jang HT. Capecitabine encapsulated chitosan succinate-sodium alginate macromolecular complex beads for colon cancer targeted delivery: in vitro evaluation. International Journal of Biological Macromolecules. 2018;117. doi:10.1016/j.ijbiomac.2018.05.181
- Venkatesan K, Rajan Babu D, Kavya Bai MP, et al. Structural and magnetic properties of cobaltdoped iron oxide nanoparticles prepared by solution combustion method for biomedical applications. International Journal of Nanomedicine. 2015;10. doi:10.2147/IJN.S82210
- Chaki SH, Malek TJ, Chaudhary MD, Tailor JP, Deshpande MP. Magnetite Fe3O4 nanoparticles synthesis by wet chemical reduction and their characterization. Advances in Natural Sciences: Nanoscience and Nanotechnology. 2015;6(3). doi:10.1088/2043-6262/6/3/035009
References
Li J, Ávila BEF de, Gao W, Zhang L, Wang J. Micro/nanorobots for Biomedicine: Delivery, surgery, sensing, and detoxification. Science Robotics. 2017;2(4). doi:10.1126/scirobotics.aam6431
Xu Z, Wu Z, Yuan M, Chen Y, Ge W, Xu Q. Versatile magnetic hydrogel soft capsule microrobots for targeted delivery. iScience. 2023;26(5). doi:10.1016/j.isci.2023.106727
Deshmukh AR, Gupta A, Kim BS. Ultrasound Assisted Green Synthesis of Silver and Iron Oxide Nanoparticles Using Fenugreek Seed Extract and Their Enhanced Antibacterial and Antioxidant Activities. BioMed Research International. 2019;2019. doi:10.1155/2019/1714358
Ghafarzadegan R, Yaghoobi M, Momtaz S, Ashouri N, Ghiaci-Yekta M, Hajiaghaee R. Process optimization for green synthesis of iron nanoparticles by extract of fenugreek (Trigonella foenum-graecum L.) seeds. Journal of Medicinal Plants. 2022;21(81). doi:10.52547/jmp.21.81.22
Li P, Pu S, Lin C, et al. Curcumin selectively induces colon cancer cell apoptosis and S cell cycle arrest by regulates Rb/E2F/p53 pathway. Journal of Molecular Structure. 2022;1263. doi:10.1016/j.molstruc.2022.133180
Kanwal Q, Ahmed M, Hamza M, et al. Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies. RSC Advances. 2023;13(32). doi:10.1039/d3ra01432k
Shakoor IF, Pamunuwa GK, Karunaratne DN. Efficacy of alginate and chickpea protein polymeric matrices in encapsulating curcumin for improved stability, sustained release and bioaccessibility. Food Hydrocolloids for Health. 2023;3. doi:10.1016/j.fhfh.2023.100119
Sinha P, Udhumansha U, Rathnam G, Ganesh M, Jang HT. Capecitabine encapsulated chitosan succinate-sodium alginate macromolecular complex beads for colon cancer targeted delivery: in vitro evaluation. International Journal of Biological Macromolecules. 2018;117. doi:10.1016/j.ijbiomac.2018.05.181
Venkatesan K, Rajan Babu D, Kavya Bai MP, et al. Structural and magnetic properties of cobaltdoped iron oxide nanoparticles prepared by solution combustion method for biomedical applications. International Journal of Nanomedicine. 2015;10. doi:10.2147/IJN.S82210
Chaki SH, Malek TJ, Chaudhary MD, Tailor JP, Deshpande MP. Magnetite Fe3O4 nanoparticles synthesis by wet chemical reduction and their characterization. Advances in Natural Sciences: Nanoscience and Nanotechnology. 2015;6(3). doi:10.1088/2043-6262/6/3/035009