Copyright (c) 2020 B. Sasi Kumar
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Role of Early Indicators in the Diagnosis and Outcome of Neonatal Sepsis in Tertiary Care Hospital Type of Manuscript
Corresponding Author(s) : B. Sasi Kumar
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 3 No. 1 (2015): 2015 Volume 3- Issue -1
Abstract
Sepsis is the commonest cause of neonatal mortality. Septicemia was the commonest clinical category with an incidence of 23 per 1000 live births. Number of screening procedures like micro ESR ,band cell count, I/T ratio, gastric aspirate for polymorphs, C –Reactive protein, alpha haptoglobin, serum fibrinogen levels have been tested in their efficacy of predicting neonatal sepsis. Positive CRP was found to be the single most sensitive and specific test in diagnosis of neonatal septicemia. The present study 180 neonates with clinical suspicion of septicemia included to evaluate the usefulness Combination of tests in septic screen in predicting neonatal sepsis. has more sensitivity and specificity than single test. CRP was positive in 94 cases (91.3%) of culture positivity with statistical significance. case fatality rate was 26.1%.
Keywords
Sepsis
Septic Screen
References
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[1] Rajiv Aggarwaf, Nupur sarkar, Ashok K. Deodari, Vinod K. Paul.Sepsis in the Newborn. Indian J Pediatr 2001;68(12):1143-7.
[2] Report of the National Neonatal Perinatal Database (National Neonatology Forum) 2002-03. NNPD Network. 2005 Jan;
http://www.newbornwhocc.org/pdf/nnpd_report_2002-03.
[3] Kuruvilla A C, Neonatal septicaemia. Indian J. Pediatrics 2002 ; 225-33.
[4] Sankar MJ, Agarwal R, Deorari AK, Paul VK. Sepsis in the newborn. Indian J Pediatr 2008; 75: 261-66.
[5] Rekha Sriram. Correlation of Blood culture results with the Sepsis score and the Sepsis screen in the diagnosis of Neonatal Septicemia. Int J Biol Med Res. 2011; 2(1): 360-368.
[6] Khatua SP, Das AK, Chatterjee BD, Khatua S, Ghose B, Saha A.Neonatal septicemia. The Indian Journal of Pediatrics 1986; 53(4):509-514.
[7] B.P Zakariya,Vishnu Bhat , B. Narasimha Harish & T. Arun Babu & N.M. Joseph. Neonatal Sepsis in a Tertiary Care Hospital in South India: Bacteriological Profile and Antibiotic Sensitivity Pattern. Indian J Pediatr (April 2011) 78(4):413–417.
[8] Nellian AR, Choudary Panna, Srinivasan S, Nalini P, Puri RK. A prospective study of bacterial infections in the newborn. Indian Journal of Pediatrics 1981; 48:427-431.
[9] Y. R. Khinchi, Anit Kumar, Satish Yadav. Profile of Neonatal sepsis. Journal of college of Medical Sciences-Nepal, 2010, Vol.6, No-2, 1-6.
[10] Ashok K Deodari. Changing pattern of bacteriological profile in neonatal sepsis among intramural babies. Journal Neonatology 2006; 20 (1):8-15.
[11] Tallur SS, Kasturi AV, Shobha D. Nadgir, Krishna BVS. Clinico-bacteriologicai Study of Neonatal Septicemia in Hubli. Indian J Pediatr 2000; 67 (3): 169-74.
[12] Joshi SG, Ghole VS, Niphadkar KB. Neonatal Gram-Negative Bacteremia. Indian J Pediatr 2000; 67(1): 27-32.
[13] S Begum, MA Baki, GK Kundu, I Islam, M Kumar, A Haque. Bacteriological Profile of Neonatal Sepsis. J Bangladesh Coll Phys Surg 2012; 30: 66-70.
[14] Gerdes JS. Diagnosis and management of bacterial infection in neonate. Paediatric ClinN Am 2004; 51: 939-959.
[15] S. Datta , JK Oberoi , TD Chugh. Laboratory diagnosis of Neonatal sepsis. Journal Neonatology 2006; 20 (l):18-23.
[16] Elizabeth Mathai, Usha Christopher, Matthews Mathai, Atanu Kumar Jana, Dolly Rose, Staffan Bergstrom. Is C-Reactive Protein level useful in differentiating infected from uninfected neonates among those at risk of infection. Indian Pediatrics 2004; 41: 895-900.
[17] Singh M, Naran A, Bhakoo ON. Evaluation of a sepsis screen in the diagnosis of neonatal sepsis. Indian pediatrics 1987; 24:39-43.
References
[1] Rajiv Aggarwaf, Nupur sarkar, Ashok K. Deodari, Vinod K. Paul.Sepsis in the Newborn. Indian J Pediatr 2001;68(12):1143-7.
[2] Report of the National Neonatal Perinatal Database (National Neonatology Forum) 2002-03. NNPD Network. 2005 Jan;
http://www.newbornwhocc.org/pdf/nnpd_report_2002-03.
[3] Kuruvilla A C, Neonatal septicaemia. Indian J. Pediatrics 2002 ; 225-33.
[4] Sankar MJ, Agarwal R, Deorari AK, Paul VK. Sepsis in the newborn. Indian J Pediatr 2008; 75: 261-66.
[5] Rekha Sriram. Correlation of Blood culture results with the Sepsis score and the Sepsis screen in the diagnosis of Neonatal Septicemia. Int J Biol Med Res. 2011; 2(1): 360-368.
[6] Khatua SP, Das AK, Chatterjee BD, Khatua S, Ghose B, Saha A.Neonatal septicemia. The Indian Journal of Pediatrics 1986; 53(4):509-514.
[7] B.P Zakariya,Vishnu Bhat , B. Narasimha Harish & T. Arun Babu & N.M. Joseph. Neonatal Sepsis in a Tertiary Care Hospital in South India: Bacteriological Profile and Antibiotic Sensitivity Pattern. Indian J Pediatr (April 2011) 78(4):413–417.
[8] Nellian AR, Choudary Panna, Srinivasan S, Nalini P, Puri RK. A prospective study of bacterial infections in the newborn. Indian Journal of Pediatrics 1981; 48:427-431.
[9] Y. R. Khinchi, Anit Kumar, Satish Yadav. Profile of Neonatal sepsis. Journal of college of Medical Sciences-Nepal, 2010, Vol.6, No-2, 1-6.
[10] Ashok K Deodari. Changing pattern of bacteriological profile in neonatal sepsis among intramural babies. Journal Neonatology 2006; 20 (1):8-15.
[11] Tallur SS, Kasturi AV, Shobha D. Nadgir, Krishna BVS. Clinico-bacteriologicai Study of Neonatal Septicemia in Hubli. Indian J Pediatr 2000; 67 (3): 169-74.
[12] Joshi SG, Ghole VS, Niphadkar KB. Neonatal Gram-Negative Bacteremia. Indian J Pediatr 2000; 67(1): 27-32.
[13] S Begum, MA Baki, GK Kundu, I Islam, M Kumar, A Haque. Bacteriological Profile of Neonatal Sepsis. J Bangladesh Coll Phys Surg 2012; 30: 66-70.
[14] Gerdes JS. Diagnosis and management of bacterial infection in neonate. Paediatric ClinN Am 2004; 51: 939-959.
[15] S. Datta , JK Oberoi , TD Chugh. Laboratory diagnosis of Neonatal sepsis. Journal Neonatology 2006; 20 (l):18-23.
[16] Elizabeth Mathai, Usha Christopher, Matthews Mathai, Atanu Kumar Jana, Dolly Rose, Staffan Bergstrom. Is C-Reactive Protein level useful in differentiating infected from uninfected neonates among those at risk of infection. Indian Pediatrics 2004; 41: 895-900.
[17] Singh M, Naran A, Bhakoo ON. Evaluation of a sepsis screen in the diagnosis of neonatal sepsis. Indian pediatrics 1987; 24:39-43.
[2] Report of the National Neonatal Perinatal Database (National Neonatology Forum) 2002-03. NNPD Network. 2005 Jan;
http://www.newbornwhocc.org/pdf/nnpd_report_2002-03.
[3] Kuruvilla A C, Neonatal septicaemia. Indian J. Pediatrics 2002 ; 225-33.
[4] Sankar MJ, Agarwal R, Deorari AK, Paul VK. Sepsis in the newborn. Indian J Pediatr 2008; 75: 261-66.
[5] Rekha Sriram. Correlation of Blood culture results with the Sepsis score and the Sepsis screen in the diagnosis of Neonatal Septicemia. Int J Biol Med Res. 2011; 2(1): 360-368.
[6] Khatua SP, Das AK, Chatterjee BD, Khatua S, Ghose B, Saha A.Neonatal septicemia. The Indian Journal of Pediatrics 1986; 53(4):509-514.
[7] B.P Zakariya,Vishnu Bhat , B. Narasimha Harish & T. Arun Babu & N.M. Joseph. Neonatal Sepsis in a Tertiary Care Hospital in South India: Bacteriological Profile and Antibiotic Sensitivity Pattern. Indian J Pediatr (April 2011) 78(4):413–417.
[8] Nellian AR, Choudary Panna, Srinivasan S, Nalini P, Puri RK. A prospective study of bacterial infections in the newborn. Indian Journal of Pediatrics 1981; 48:427-431.
[9] Y. R. Khinchi, Anit Kumar, Satish Yadav. Profile of Neonatal sepsis. Journal of college of Medical Sciences-Nepal, 2010, Vol.6, No-2, 1-6.
[10] Ashok K Deodari. Changing pattern of bacteriological profile in neonatal sepsis among intramural babies. Journal Neonatology 2006; 20 (1):8-15.
[11] Tallur SS, Kasturi AV, Shobha D. Nadgir, Krishna BVS. Clinico-bacteriologicai Study of Neonatal Septicemia in Hubli. Indian J Pediatr 2000; 67 (3): 169-74.
[12] Joshi SG, Ghole VS, Niphadkar KB. Neonatal Gram-Negative Bacteremia. Indian J Pediatr 2000; 67(1): 27-32.
[13] S Begum, MA Baki, GK Kundu, I Islam, M Kumar, A Haque. Bacteriological Profile of Neonatal Sepsis. J Bangladesh Coll Phys Surg 2012; 30: 66-70.
[14] Gerdes JS. Diagnosis and management of bacterial infection in neonate. Paediatric ClinN Am 2004; 51: 939-959.
[15] S. Datta , JK Oberoi , TD Chugh. Laboratory diagnosis of Neonatal sepsis. Journal Neonatology 2006; 20 (l):18-23.
[16] Elizabeth Mathai, Usha Christopher, Matthews Mathai, Atanu Kumar Jana, Dolly Rose, Staffan Bergstrom. Is C-Reactive Protein level useful in differentiating infected from uninfected neonates among those at risk of infection. Indian Pediatrics 2004; 41: 895-900.
[17] Singh M, Naran A, Bhakoo ON. Evaluation of a sepsis screen in the diagnosis of neonatal sepsis. Indian pediatrics 1987; 24:39-43.