Preparation of fast dissolving oral film containing solid dispersion of carvedilol, a poorly water-soluble drug
Corresponding Author(s) : Aman Kansare
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 11 No. 3 (2023): 2023 Volume -11 - Issue 3
Abstract
One of the leading causes of death and disability throughout the globe is hypertension. Ischemic or hemorrhagic stroke, myocardial infarction, heart failure, chronic renal disease, cognitive decline, and premature mortality are all increased by hypertension. Important medications for treating hypertension include carvedilol. The current treatment of hypertension with the aforementioned drugs has a number of drawbacks, according to a literature review, including a slow onset of action, extensive first pass metabolism, a high dosage regimen, poor bioavailability, and patient incompliance due to side effects like dysphasia. In order to get around these problems, we created and tested fast-dissolving oral films of solid dispersion of drug Carvedilol for oral buccal delivery.
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- Natalie S. Hypertension: a review of antihypertensive medication: past and present. S Afr Pharm J. 2015;82(2):17-25.
- Teofilo V, Bruno S, Paulo C. Solid dispersion as strategy to improve oral bioavailability poor water soluble drugs. Drug Discov Today. 2007;12(23/24):1068-75.
- Park K. Dissolution mechanisms of felodipine solid dispersions. J Control Release. 2014; 188:101. doi: 10.1016/j.jconrel.2014.07.036, PMID 25079035.
- Ratnakar R, Goswami L, Kothiyal P. Formulation and evaluation of fast dissolving tablet of telmisartan. Int J Pharm Chem Sci. 2013;2(4):2078-85.
- Shinkar DM, Dhake AS, Mallikarjuna SC. Development of UV spectrophotometric method for estimation of carvedilol in bulk and pharmaceutical formulations. Asian J Res Chem. 2013;6(10):956959.
- Shimoda H, Taniguchi K, Nishimura M, Matsuura K, Tsukioka T, Yamashita H et al. Preparation of a fast dissolving oral thin film containing dexamethasone: A possible application to antiemesis during cancer chemotherapy. Eur J Pharm Biopharm. 2009;73(3):361-5. doi: 10.1016/j.ejpb.2009.08.010, PMID 19735731.
- Xu LL, Shi LL, Cao QR, Xu WJ, Cao Y, Zhu XY et al. Formulation and in-vitro characterization of novel sildenafil citrate loaded polyvinyl alcohol-polyethylene glycol graft copolymer-based orally dissolving films. Int J Pharm. 2014;473(1-2):398-406. doi: 10.1016/j.ijpharm.2014.07.037, PMID 25079431.
- Dehghan MMJ, Shareef A. Enhancement of dissolution and antiinflammatory effect of meloxicam using solid dispersions. Int J Appl Pharm. 2010;2(1):22-7.
- Dewan I, Hossain MA, Islam SMA. Formulation and evaluation of solid dispersions of carvedilol, a poorly water soluble drug by using different polymers. Int J Res Pharm Chem. 2012;2(3):585593.
- Kothawade SN, Kadam NR, Aragade PD, Baheti DG. Formulation and characterization of telmisartan solid dispersions. Int J PharmTech Res. 2010;2(1):341-7.
- Someshwar K, Rama G, Harikiran L, Krishna K, Srinivas A. Dissolution enhancement of a poorly water soluble drug using water soluble carriers. Adv Pharm Sci. 2011;1(1):42-6.
- Rubia BY, Firoz S, Chandra YM, Vikram A, Mahitha B, Aruna U. Preparation and evaluation of oral fast dissolving films of citalopram hydrobromide. Int J Biopharm. 2012;3(2):103-6.
- Visser JC, Dohmen WMC, Hinrichs WLJ, Breitkreutz J, Frijlink HW, Woerdenbag HJ. Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films. Int J Pharm. 2015;485(1-2):70-6. doi: 10.1016/j.ijpharm.2015.03.005, PMID 25746737.
- Jain AK. Solubilization of indomethacin using hydrotropes for aqueous injection. Eur J Pharm Biopharm. 2008;68(3):701-14. doi: 10.1016/j.ejpb.2007.06.013, PMID 17716879.
- Kshirsagar SJ, Ubhe A, Malshe J, Sengaokar V. A modified solvent method for preparation of solid dispersions. Iran J Pharm Sci. 2011;8(1):287-98.
- Begam M, Datta MV, Gowda DV, Aravindaram AS. Development and characterization of co-ground mixtures and solid dispersions of aripiprazole with hydrophilic carriers. Int J Pharm Pharm Sci. 2014;6(2):552-7.
- Meshad ANE, Hagrasy ASE 2011. Characterization and optimization of orodispersible Mosapride film formulations. American association of pharmaceutical scientists. 12(4),1384-92.
- Ketul P, Patel K, Patel M, Patel NM. Design and development of telmisartan fast dissolving film. Int J Adv Pharm. 2014;4(1):1-5.
- Kumar DS, Reddy BA, Tiwari AK, Swetha B, Dey S. Formulation and evaluation of mouth dissolving tablets of felodipine. Asian J Pharm Clin Res. 2011;4(1):47-51.
- Nagar M, Nagar M, Chopra V. Formulation and evaluation of mouth dissolving film of aripiprazole. Pharmacia [letter]. 2012;4(4):1221-7.
- Woertz C, Kleinebudde P. Development of orodispersible polymer films containing poorly water soluble active pharmaceutical ingredients with focus on different drug loadings and storage stability. Int J Pharm. 2015;493(1-2):134-45. doi: 10.1016/j.ijpharm.2015.07.032, PMID 26216415.
- Choudhary DR, Patel VA, Chhalotiya UK, Patel HV, Kundawala AJ. Development and characterization of pharmacokinetic parameters of fastdissolving films containing levocetirizine. Sci Pharm. 2012;80(3):779-87. doi: 10.3797/scipharm.1205-15, PMID 23008821.
References
Natalie S. Hypertension: a review of antihypertensive medication: past and present. S Afr Pharm J. 2015;82(2):17-25.
Teofilo V, Bruno S, Paulo C. Solid dispersion as strategy to improve oral bioavailability poor water soluble drugs. Drug Discov Today. 2007;12(23/24):1068-75.
Park K. Dissolution mechanisms of felodipine solid dispersions. J Control Release. 2014; 188:101. doi: 10.1016/j.jconrel.2014.07.036, PMID 25079035.
Ratnakar R, Goswami L, Kothiyal P. Formulation and evaluation of fast dissolving tablet of telmisartan. Int J Pharm Chem Sci. 2013;2(4):2078-85.
Shinkar DM, Dhake AS, Mallikarjuna SC. Development of UV spectrophotometric method for estimation of carvedilol in bulk and pharmaceutical formulations. Asian J Res Chem. 2013;6(10):956959.
Shimoda H, Taniguchi K, Nishimura M, Matsuura K, Tsukioka T, Yamashita H et al. Preparation of a fast dissolving oral thin film containing dexamethasone: A possible application to antiemesis during cancer chemotherapy. Eur J Pharm Biopharm. 2009;73(3):361-5. doi: 10.1016/j.ejpb.2009.08.010, PMID 19735731.
Xu LL, Shi LL, Cao QR, Xu WJ, Cao Y, Zhu XY et al. Formulation and in-vitro characterization of novel sildenafil citrate loaded polyvinyl alcohol-polyethylene glycol graft copolymer-based orally dissolving films. Int J Pharm. 2014;473(1-2):398-406. doi: 10.1016/j.ijpharm.2014.07.037, PMID 25079431.
Dehghan MMJ, Shareef A. Enhancement of dissolution and antiinflammatory effect of meloxicam using solid dispersions. Int J Appl Pharm. 2010;2(1):22-7.
Dewan I, Hossain MA, Islam SMA. Formulation and evaluation of solid dispersions of carvedilol, a poorly water soluble drug by using different polymers. Int J Res Pharm Chem. 2012;2(3):585593.
Kothawade SN, Kadam NR, Aragade PD, Baheti DG. Formulation and characterization of telmisartan solid dispersions. Int J PharmTech Res. 2010;2(1):341-7.
Someshwar K, Rama G, Harikiran L, Krishna K, Srinivas A. Dissolution enhancement of a poorly water soluble drug using water soluble carriers. Adv Pharm Sci. 2011;1(1):42-6.
Rubia BY, Firoz S, Chandra YM, Vikram A, Mahitha B, Aruna U. Preparation and evaluation of oral fast dissolving films of citalopram hydrobromide. Int J Biopharm. 2012;3(2):103-6.
Visser JC, Dohmen WMC, Hinrichs WLJ, Breitkreutz J, Frijlink HW, Woerdenbag HJ. Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films. Int J Pharm. 2015;485(1-2):70-6. doi: 10.1016/j.ijpharm.2015.03.005, PMID 25746737.
Jain AK. Solubilization of indomethacin using hydrotropes for aqueous injection. Eur J Pharm Biopharm. 2008;68(3):701-14. doi: 10.1016/j.ejpb.2007.06.013, PMID 17716879.
Kshirsagar SJ, Ubhe A, Malshe J, Sengaokar V. A modified solvent method for preparation of solid dispersions. Iran J Pharm Sci. 2011;8(1):287-98.
Begam M, Datta MV, Gowda DV, Aravindaram AS. Development and characterization of co-ground mixtures and solid dispersions of aripiprazole with hydrophilic carriers. Int J Pharm Pharm Sci. 2014;6(2):552-7.
Meshad ANE, Hagrasy ASE 2011. Characterization and optimization of orodispersible Mosapride film formulations. American association of pharmaceutical scientists. 12(4),1384-92.
Ketul P, Patel K, Patel M, Patel NM. Design and development of telmisartan fast dissolving film. Int J Adv Pharm. 2014;4(1):1-5.
Kumar DS, Reddy BA, Tiwari AK, Swetha B, Dey S. Formulation and evaluation of mouth dissolving tablets of felodipine. Asian J Pharm Clin Res. 2011;4(1):47-51.
Nagar M, Nagar M, Chopra V. Formulation and evaluation of mouth dissolving film of aripiprazole. Pharmacia [letter]. 2012;4(4):1221-7.
Woertz C, Kleinebudde P. Development of orodispersible polymer films containing poorly water soluble active pharmaceutical ingredients with focus on different drug loadings and storage stability. Int J Pharm. 2015;493(1-2):134-45. doi: 10.1016/j.ijpharm.2015.07.032, PMID 26216415.
Choudhary DR, Patel VA, Chhalotiya UK, Patel HV, Kundawala AJ. Development and characterization of pharmacokinetic parameters of fastdissolving films containing levocetirizine. Sci Pharm. 2012;80(3):779-87. doi: 10.3797/scipharm.1205-15, PMID 23008821.