Antinociceptive activity of aqueous leaf extracts of boussingaultia gracilis
Corresponding Author(s) : Dr.Bijoy Chirayath
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 3 No. 1 (2015): 2015 Volume 3- Issue -1
Abstract
The aqueous leaf extracts of Boussingaultia gracilis is used for hepatoprotective, ulcer, fever and rheumatism. The present study was undertaken to evaluate the analgesic activity of the aqueous extract of Boussingaultia gracilis (Bassellaceae) aqueous leaf (BGPE) was investigated in chemical models of nociception in mice. BGPE at doses of 100, 200 and 400 mg/kg p.o produced an inhibition of 29.22%, 51.80% and 79.87% of the abdominal writhes induced by acetic acid in mice. In the formalin test, the administration of 100, 200 and 400mg/kg p.o had no effects in the first phase (0–5 min) but produced a dose-dependent analgesic effect on the second phase (15–40 min) with inhibitions of the licking time of 31.54%, 45.27% and 60.52% respectively. Based on the results of this study, we suggest that the peripheral analgesic effect of Boussingaultia gracilis may be attributed to inhibition of prostaglandin release and other mediators involved. Further studies are needed to evaluate the mechanism of action of the analgesic activity of the Boussingaultia gracilis. The result obtained shows that the Boussingaultia gracilis possesses an adequate significant analgesic activity which confirms the claims of traditional uses of the plant leaf.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
-
[1] Schaible HG, Richter F. Pathophysiology of pain. Langenbecks Arch Surg, 389 (4), 2004, 237–243.
[2] Basbaum A, Bushnell C. Pain: basic mechanisms: World Congress on Pain (10th, San Diego, Calif). Pain, 1, 2002, 3–7.
[3] Madhava Chetty K. Ipomoea eriocarpa. Chittoor medicinal plants, Himalaya Book Publications, Tirupati, 2005, pp 590.
[4] Ahmed F, Selim MST, Das AK, Choudhuri MSK, 2004. Antiinflammatory and antinociceptive activities of Lippia nodiflora Linn. Pharmazie, 59: 329-333.
[5] Koster R, Anderson M and De Beer EJ. Acetic acid analgesic screen, Federation Proceedings, 18, 1959, 412–420.
[6] Hunskaar S and Hole K. Pain, 30, 1987, 103–114.
[7] Tjolsen A, Berge OG, Hunskaar S, Rosland JH and Hole K. Pain, 51, 1992, 5–17.
[8] Chen Q. Methodology in pharmacological study on Chinese Materia Medica, People's Medical Publishing House, Beijing, 1993, pp. 360.
[9] Martinez V, Thakur S, Mogil JS, Tach´e Y, Mayer EA. Pain, 81, 1999, 179- 186.
[10] Shibata M, Ohkubo T, Takahashi H and Inoki R. Pain, 1989, 38, 1989, 347–352.
[11] Hunskaar S and Hole K. Pain, 30, 1987, 103–114.
[12] Rosland JH, Tjolsen A, Maehle B and Hole K. Pain, 42, 1990, 235–242.
[13] OECD, 2002. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the, OECD, guidelines for the testing of chemicals organisation for economical co-operation and development, Paris, June, 2000.
[14] Chiang LC, Cheng HY, Liu MC, Chiang W, Lin CC. In vitro antiherpes simplex viruses and anti-adenoviruses activity of twelve traditionally used medicinal plants in Taiwan. Biol Pharm Bull 2003; 26: 1600-4
References
[2] Basbaum A, Bushnell C. Pain: basic mechanisms: World Congress on Pain (10th, San Diego, Calif). Pain, 1, 2002, 3–7.
[3] Madhava Chetty K. Ipomoea eriocarpa. Chittoor medicinal plants, Himalaya Book Publications, Tirupati, 2005, pp 590.
[4] Ahmed F, Selim MST, Das AK, Choudhuri MSK, 2004. Antiinflammatory and antinociceptive activities of Lippia nodiflora Linn. Pharmazie, 59: 329-333.
[5] Koster R, Anderson M and De Beer EJ. Acetic acid analgesic screen, Federation Proceedings, 18, 1959, 412–420.
[6] Hunskaar S and Hole K. Pain, 30, 1987, 103–114.
[7] Tjolsen A, Berge OG, Hunskaar S, Rosland JH and Hole K. Pain, 51, 1992, 5–17.
[8] Chen Q. Methodology in pharmacological study on Chinese Materia Medica, People's Medical Publishing House, Beijing, 1993, pp. 360.
[9] Martinez V, Thakur S, Mogil JS, Tach´e Y, Mayer EA. Pain, 81, 1999, 179- 186.
[10] Shibata M, Ohkubo T, Takahashi H and Inoki R. Pain, 1989, 38, 1989, 347–352.
[11] Hunskaar S and Hole K. Pain, 30, 1987, 103–114.
[12] Rosland JH, Tjolsen A, Maehle B and Hole K. Pain, 42, 1990, 235–242.
[13] OECD, 2002. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the, OECD, guidelines for the testing of chemicals organisation for economical co-operation and development, Paris, June, 2000.
[14] Chiang LC, Cheng HY, Liu MC, Chiang W, Lin CC. In vitro antiherpes simplex viruses and anti-adenoviruses activity of twelve traditionally used medicinal plants in Taiwan. Biol Pharm Bull 2003; 26: 1600-4