Effect of Kenop Flower Extract (Gomphrena Globosa) on Blood Pressure Reduction in Hypertension Female Rats
Corresponding Author(s) : Nurazizah Putri Rahayu
nurazizahputrirahayu@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 11 No. 1 (2023): 2023 Volume -11 - Issue 1
Abstract
Background: Hypertension experienced, especially women of childbearing age are more susceptible to complications from cardiovascular disease as well as having an impact on pregnancy. One of the medicinal plants used by the community is the kenop flower (Gomphrena globosa) but there has been no research or clinical trial on humans. Thus, a strong preclinical basis is needed through animal testing to establish dosage and quality before conducting large-scale clinical trials in humans.
Objective: The researcher analyzed the kenop flower extract as an alternative to decreasing systolic and diastolic blood pressure in hypertensive female white rats.
Methods: The research design is a true experimental laboratory experiment using experimental animals by giving treatment to white rats (Rattus norvegicus) with a pretest-posttest control group design. This study used 3 groups of white rats, namely: 2 experimental groups with doses of 2.76mg/kgBW and 252mg/kgBW given once a day for ten days, and 1 control group without extract. Statistical test using Anova Repeated Measure, Paired T-test, and Independent t-test
Research Results: Experimental group 1 has shown a significant difference in the pretest and 2nd posttest observations with a p-value of 0.001. Experimental group 2 had a significant difference since the time of comparison of the pretest and 1st posttest observations with a p-value of 0.000. The comparison between the pretest and 2nd posttest observations shows a p-value of 0.000 < 0,05.
Conclusion: Kenop flower extract can reduce blood pressure in rats with hypertension and this study was conducted in vivo, so further testing is needed.
Objective: The researcher analyzed the kenop flower extract as an alternative to decreasing systolic and diastolic blood pressure in hypertensive female white rats.
Methods: The research design is a true experimental laboratory experiment using experimental animals by giving treatment to white rats (Rattus norvegicus) with a pretest-posttest control group design. This study used 3 groups of white rats, namely: 2 experimental groups with doses of 2.76mg/kgBW and 252mg/kgBW given once a day for ten days, and 1 control group without extract. Statistical test using Anova Repeated Measure, Paired T-test, and Independent t-test
Research Results: Experimental group 1 has shown a significant difference in the pretest and 2nd posttest observations with a p-value of 0.001. Experimental group 2 had a significant difference since the time of comparison of the pretest and 1st posttest observations with a p-value of 0.000. The comparison between the pretest and 2nd posttest observations shows a p-value of 0.000 < 0,05.
Conclusion: Kenop flower extract can reduce blood pressure in rats with hypertension and this study was conducted in vivo, so further testing is needed.
Keywords
Kenop Flower Extract
Gomphrena globosa
hypertension
1.
Putri Rahayu N, Krisdiana Wijayanti, M.Mid, Sudirman, MN. Effect of Kenop Flower Extract (Gomphrena Globosa) on Blood Pressure Reduction in Hypertension Female Rats. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2023 Mar. 10 [cited 2026 Apr. 13];11(1):55-8. Available from: https://ijamscr.com/ijamscr/article/view/1294
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References
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Arthi, V. dan Prasanna, G. (2016) “Hptlc finger print profile and in vitro antioxidant activity of Gomphrena Globosa L. Flowers,” International Journal of Pharmaceutical Sciences Review and Research, 39(1), hal. 208–215.
Beg, M. et al. (2011) “Role of antioxidants in hypertension,” Journal, Indian Academy of Clinical Medicine, 12(2), hal. 122–127.
Fitri, M. N., Choirunissa, R. dan Rifiana, A. julia (2020) “Pengaruh Konsumsi Labu Siam (Cucurbitaceae) Terhadap Perubahan Tekanan Darah,” 12(2), hal. 169–178. doi: DOI: https://doi.org/10.37012/jik.v12i2.258.
Ikewuchi, J. C. et al. (2014) “Blood pressure lowering activity of a flavonoid and phytosterol rich extract of the sclerotia of pleurotus tuberregium (fr) sing in salt-loaded rats,” Biomedicine and Preventive Nutrition, 4(2), hal. 257–263. doi: 10.1016/j.bionut.2014.02.006.
Kemenkes RI (2019) “Hipertensi Si Pembunuh Senyap,” Kementrian Kesehatan RI, hal. 1–5.
Kementerian Kesehatan RI. (2020) Profil Kesehatan Indonesia Tahun 2019. Diedit oleh Hardhana B, Sibuea F, dan Widiantini W. Jakarta: Kementrian Kesehatan Republik Indonesia.
Kusmiati, K., Priadi, D. dan Rahayu, R. K. B. R. (2017) “Antibacterial Activity Test, Evaluation of Pharmacognosy and Phytochemical Screening of Some Extracts of Globe Amaranth (Gomphrena globosa),” The Journal of Pure and Applied Chemistry Research, 6(1), hal. 27–33. doi: 10.21776/ub.jpacr.2017.006.01.288.
Lestaridewi, N. K. dan Jamhari, M. (2017) “Kajian Pemanfaatan Tanaman Sebagai Obat Tradisional Di Desa Tolai Kecamatan Torue Kabupaten Parigi Moutong,” e-Jip Biol, 5(2), hal. 1–19.
Mahendradhata, Y. et al. (2017) “The Republic of Indonesia Health System Review,” in Hort, K. dan Patcharanarumol, W. (ed.). WHO Library Cataloguing.
Nungraheni, F. R., Rahayuning, D. dan Nugraheni, S. A. (2018) “Hubungan Asupan Mineral, Indeks Massa Tubuh Dan Persentase Lemak Tubuh Terhadap Tekanan Darah Wanita Usia Subur.,” Jurnal kesehatan masyarakat, 6(5). doi: DOI: https://doi.org/10.14710/jkm.v6i5.22058.
Sepriandi, Sri Mudayatiningsih dan Susmini (2017) “Hipertensi pada wanita pasangan usia subur dengan lama penggunaan pil kb,” Nursing News, 2(3), hal. 823–832. doi: DOI: https://doi.org/10.33366/nn.v2i3.718.
Setiati, S. et al. (2017) Buku Ajar Ilmu Penyakit Dalam Jilid II Edisi VI. Jakarta: InternalPubliching.
Subandrate, Faisal, M. E. dan Anggraini, N. W. (2017) “Peranan Stres Oksidatif pada Preeklampsia,” Cermin Dunia Kedokteran, 44(5), hal. 353–355.
Susilaningrum, D. F. dan Wijayanti, N. (2020) “Antioxidant potential and cytotoxic assay of ethanol extract of gomphrena globosa L. Flower,” AIP Conference Proceedings, 2260. doi: 10.1063/5.0015685.
Trends in maternal mortality 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. (2019) Geneva: World Health Organization.
References
Arthi, V. dan Prasanna, G. (2016) “Hptlc finger print profile and in vitro antioxidant activity of Gomphrena Globosa L. Flowers,” International Journal of Pharmaceutical Sciences Review and Research, 39(1), hal. 208–215.
Beg, M. et al. (2011) “Role of antioxidants in hypertension,” Journal, Indian Academy of Clinical Medicine, 12(2), hal. 122–127.
Fitri, M. N., Choirunissa, R. dan Rifiana, A. julia (2020) “Pengaruh Konsumsi Labu Siam (Cucurbitaceae) Terhadap Perubahan Tekanan Darah,” 12(2), hal. 169–178. doi: DOI: https://doi.org/10.37012/jik.v12i2.258.
Ikewuchi, J. C. et al. (2014) “Blood pressure lowering activity of a flavonoid and phytosterol rich extract of the sclerotia of pleurotus tuberregium (fr) sing in salt-loaded rats,” Biomedicine and Preventive Nutrition, 4(2), hal. 257–263. doi: 10.1016/j.bionut.2014.02.006.
Kemenkes RI (2019) “Hipertensi Si Pembunuh Senyap,” Kementrian Kesehatan RI, hal. 1–5.
Kementerian Kesehatan RI. (2020) Profil Kesehatan Indonesia Tahun 2019. Diedit oleh Hardhana B, Sibuea F, dan Widiantini W. Jakarta: Kementrian Kesehatan Republik Indonesia.
Kusmiati, K., Priadi, D. dan Rahayu, R. K. B. R. (2017) “Antibacterial Activity Test, Evaluation of Pharmacognosy and Phytochemical Screening of Some Extracts of Globe Amaranth (Gomphrena globosa),” The Journal of Pure and Applied Chemistry Research, 6(1), hal. 27–33. doi: 10.21776/ub.jpacr.2017.006.01.288.
Lestaridewi, N. K. dan Jamhari, M. (2017) “Kajian Pemanfaatan Tanaman Sebagai Obat Tradisional Di Desa Tolai Kecamatan Torue Kabupaten Parigi Moutong,” e-Jip Biol, 5(2), hal. 1–19.
Mahendradhata, Y. et al. (2017) “The Republic of Indonesia Health System Review,” in Hort, K. dan Patcharanarumol, W. (ed.). WHO Library Cataloguing.
Nungraheni, F. R., Rahayuning, D. dan Nugraheni, S. A. (2018) “Hubungan Asupan Mineral, Indeks Massa Tubuh Dan Persentase Lemak Tubuh Terhadap Tekanan Darah Wanita Usia Subur.,” Jurnal kesehatan masyarakat, 6(5). doi: DOI: https://doi.org/10.14710/jkm.v6i5.22058.
Sepriandi, Sri Mudayatiningsih dan Susmini (2017) “Hipertensi pada wanita pasangan usia subur dengan lama penggunaan pil kb,” Nursing News, 2(3), hal. 823–832. doi: DOI: https://doi.org/10.33366/nn.v2i3.718.
Setiati, S. et al. (2017) Buku Ajar Ilmu Penyakit Dalam Jilid II Edisi VI. Jakarta: InternalPubliching.
Subandrate, Faisal, M. E. dan Anggraini, N. W. (2017) “Peranan Stres Oksidatif pada Preeklampsia,” Cermin Dunia Kedokteran, 44(5), hal. 353–355.
Susilaningrum, D. F. dan Wijayanti, N. (2020) “Antioxidant potential and cytotoxic assay of ethanol extract of gomphrena globosa L. Flower,” AIP Conference Proceedings, 2260. doi: 10.1063/5.0015685.
Trends in maternal mortality 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. (2019) Geneva: World Health Organization.
Beg, M. et al. (2011) “Role of antioxidants in hypertension,” Journal, Indian Academy of Clinical Medicine, 12(2), hal. 122–127.
Fitri, M. N., Choirunissa, R. dan Rifiana, A. julia (2020) “Pengaruh Konsumsi Labu Siam (Cucurbitaceae) Terhadap Perubahan Tekanan Darah,” 12(2), hal. 169–178. doi: DOI: https://doi.org/10.37012/jik.v12i2.258.
Ikewuchi, J. C. et al. (2014) “Blood pressure lowering activity of a flavonoid and phytosterol rich extract of the sclerotia of pleurotus tuberregium (fr) sing in salt-loaded rats,” Biomedicine and Preventive Nutrition, 4(2), hal. 257–263. doi: 10.1016/j.bionut.2014.02.006.
Kemenkes RI (2019) “Hipertensi Si Pembunuh Senyap,” Kementrian Kesehatan RI, hal. 1–5.
Kementerian Kesehatan RI. (2020) Profil Kesehatan Indonesia Tahun 2019. Diedit oleh Hardhana B, Sibuea F, dan Widiantini W. Jakarta: Kementrian Kesehatan Republik Indonesia.
Kusmiati, K., Priadi, D. dan Rahayu, R. K. B. R. (2017) “Antibacterial Activity Test, Evaluation of Pharmacognosy and Phytochemical Screening of Some Extracts of Globe Amaranth (Gomphrena globosa),” The Journal of Pure and Applied Chemistry Research, 6(1), hal. 27–33. doi: 10.21776/ub.jpacr.2017.006.01.288.
Lestaridewi, N. K. dan Jamhari, M. (2017) “Kajian Pemanfaatan Tanaman Sebagai Obat Tradisional Di Desa Tolai Kecamatan Torue Kabupaten Parigi Moutong,” e-Jip Biol, 5(2), hal. 1–19.
Mahendradhata, Y. et al. (2017) “The Republic of Indonesia Health System Review,” in Hort, K. dan Patcharanarumol, W. (ed.). WHO Library Cataloguing.
Nungraheni, F. R., Rahayuning, D. dan Nugraheni, S. A. (2018) “Hubungan Asupan Mineral, Indeks Massa Tubuh Dan Persentase Lemak Tubuh Terhadap Tekanan Darah Wanita Usia Subur.,” Jurnal kesehatan masyarakat, 6(5). doi: DOI: https://doi.org/10.14710/jkm.v6i5.22058.
Sepriandi, Sri Mudayatiningsih dan Susmini (2017) “Hipertensi pada wanita pasangan usia subur dengan lama penggunaan pil kb,” Nursing News, 2(3), hal. 823–832. doi: DOI: https://doi.org/10.33366/nn.v2i3.718.
Setiati, S. et al. (2017) Buku Ajar Ilmu Penyakit Dalam Jilid II Edisi VI. Jakarta: InternalPubliching.
Subandrate, Faisal, M. E. dan Anggraini, N. W. (2017) “Peranan Stres Oksidatif pada Preeklampsia,” Cermin Dunia Kedokteran, 44(5), hal. 353–355.
Susilaningrum, D. F. dan Wijayanti, N. (2020) “Antioxidant potential and cytotoxic assay of ethanol extract of gomphrena globosa L. Flower,” AIP Conference Proceedings, 2260. doi: 10.1063/5.0015685.
Trends in maternal mortality 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. (2019) Geneva: World Health Organization.