Copyright (c) 2020 Vishwanatha Reddy M.S
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Asymptomatic Candiduria in HIV Seropositives Attending an ART Centre in a Tertiary Care Hospital
Corresponding Author(s) : Vishwanatha Reddy M.S
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 3 No. 1 (2015): 2015 Volume 3- Issue -1
Abstract
Background
Most of patients with candiduria are asymptomatic. However, in immunocompromised patients like HIV-infected individuals, it has high risk of morbidity and mortality as it is a good indicator of disseminated infection and fungemia.
Aim
To isolate and characterize Candida species in HIV seropositives patients with asymptomatic candiduria and to determine distribution of Candida species in different CD4+ cell counts categories.
Materials and methods
The study group comprised of 55 males and 45 females, of which 50 were on ART and 50 were not on ART. Clean catch mid stream urine specimens were collected from patients and urine was inoculated on SDA, incubated at 370 for 48-72 hours.
Results
14 of 100 subjects had candiduria. Out of 14 Candida species, 5 candida albicans and 9 non-albicans candida species were isolated. The prevalence of candiduria was high among patients who were not on HAART (43%) than in individuals who were on HAART (18%) with CD4+ count >200 cells/?l.
Conclusion
Measures to reduce candiduria prevalence, such as early diagnosis, prompt treatment with appropriate antifungals and strict compliance with HAART regimen are advocated to reduce the morbidity and mortality in HIV positive patients.
Keywords
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1. WHO. Laboratory manual for the diagnosis of fungal opportunistic infection in HIV/AIDS patients. New Delhi (India): WHO Regional office for South-East Asia; 2009:1-92.
2. Maryam Moazeni, Dariush Haghmorad and Abbas Mirshafiey. Opportunistic fungal infections in patients with HIV and AIDS. Journal of Chinese clinical medicine; 2009:4(2).
3. JP Lohoue, FFAngawafo III, FA Kechia and ND Noukeu. Candiduria in HIV infected patients in Yaundi, Cameroon.African Journal of Urology; 2005(11):61-6.
4. Newton O.Eslbelahie,Ifeoma B Enweani and Richard Omoregie. Candida colonization in asymptomatic HIV patients attending a tertiary hospital in Benin city,Nigeria.Libyan J Med 2013.
5. Gordana M . Bojia Miliaevia, Momir M. Mikov, Svetlana M. Goloaorbin-Kohn. The importance of genus candida in human samples. Proc. Nat. Sci, Matica Srpska Novi Sad, 114, 79-95, 2008.
6. Carol A. Kauffman. Candiduria. Clinical Infectious Diseases 2005; 41:S371–6.
7. Patrica M.Tille,. Bailey and Scott’s Diagnostic Microbiology.13th ed. Mosby Elsevier. Philadelphia, USA; 2014:773.
8. Esebelahie, N. O,. Enweani, I. B., Newton-Esebelahie, F. O., Omoregie. Candiduria among HIV- Infected Patients Attending A Tertiary Hospital In Benin City. AFR. J. CLN. EXPER. MICROBIOL 2014; 15(2): 84-90.
9. Jagadish Chander. Textbook of Medical Mycology, Mehta publishers 3rd edition 2009:272.
10. Longdoh A. Njunda, Jules C. N. Assob, Shey D. Nsagha, Henri L. F. Kamga, Ejong C. Ndellejong, Tebit E. Kwenti. Oral and Urinary Colonisation of Candida Species in HIV/AIDS Patients in Cameroon. Basic Sciences of Medicine 2013, 2(1): 1-8.
11. Wadhwa, Ravinder K, Satish KA, Shyama J, Preena B. AIDS- related opportunistic mycoses seen in a tertiary hospital in North India. J MED Microbiol.2007; 56:1101-6.
References
2. Maryam Moazeni, Dariush Haghmorad and Abbas Mirshafiey. Opportunistic fungal infections in patients with HIV and AIDS. Journal of Chinese clinical medicine; 2009:4(2).
3. JP Lohoue, FFAngawafo III, FA Kechia and ND Noukeu. Candiduria in HIV infected patients in Yaundi, Cameroon.African Journal of Urology; 2005(11):61-6.
4. Newton O.Eslbelahie,Ifeoma B Enweani and Richard Omoregie. Candida colonization in asymptomatic HIV patients attending a tertiary hospital in Benin city,Nigeria.Libyan J Med 2013.
5. Gordana M . Bojia Miliaevia, Momir M. Mikov, Svetlana M. Goloaorbin-Kohn. The importance of genus candida in human samples. Proc. Nat. Sci, Matica Srpska Novi Sad, 114, 79-95, 2008.
6. Carol A. Kauffman. Candiduria. Clinical Infectious Diseases 2005; 41:S371–6.
7. Patrica M.Tille,. Bailey and Scott’s Diagnostic Microbiology.13th ed. Mosby Elsevier. Philadelphia, USA; 2014:773.
8. Esebelahie, N. O,. Enweani, I. B., Newton-Esebelahie, F. O., Omoregie. Candiduria among HIV- Infected Patients Attending A Tertiary Hospital In Benin City. AFR. J. CLN. EXPER. MICROBIOL 2014; 15(2): 84-90.
9. Jagadish Chander. Textbook of Medical Mycology, Mehta publishers 3rd edition 2009:272.
10. Longdoh A. Njunda, Jules C. N. Assob, Shey D. Nsagha, Henri L. F. Kamga, Ejong C. Ndellejong, Tebit E. Kwenti. Oral and Urinary Colonisation of Candida Species in HIV/AIDS Patients in Cameroon. Basic Sciences of Medicine 2013, 2(1): 1-8.
11. Wadhwa, Ravinder K, Satish KA, Shyama J, Preena B. AIDS- related opportunistic mycoses seen in a tertiary hospital in North India. J MED Microbiol.2007; 56:1101-6.