A Rare Pediatric Case Report of MOG Positive Parainfectious Longitudinal Extensive Transverse Myelitis

Abstract

MOG-AD is a distinct nosological entity with specific management and therapeutic requirements.1 Optic neuritis is the most frequent presenting phenotype. The disease course can be either monophasic or relapsing, with subsequent relapses most commonly involving the optic nerve. MOG-associated myelitis is a less frequent clinical phenotype observed in children at their initial event. In the present article, we present a rare pediatric case of clinically diagnosed transverse myelitis with a positive anti-MOG antibody. A 13 year-old patient presented with weakness on both legs and decreased sensation below T2 level with bowel and bladder retention 2 weeks preceding a varicella infection. MOGAD may be a severe relapsing and devastating disorder for a subgroup of patients. Moderate response to current standard chronic therapies. Additional safe and long-term efficacious treatment options are still much needed for children with relapsing MOGAD.