In Vivo Study Wound Healing Potential (Incision) of Herbal Formulation
Corresponding Author(s) : Mohammed Wasiullah
drwasipharma@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 2 No. 4 (2014): 2014 Volume 2- Issue -4
Abstract
Lygodium flexuosum is a climbing fern it is the sole genus in the family Lygodiaceae, though it is included in the family Schizaceae by some botanist. It occurs on mangrove and had tree dominated habitat sub division is petridophyte and had life form of cryptophytes category. It is commonly epiphytically grows on moss covered tree trunks, branches a lithophytes on shady boulders along with moss and in Thailand its habitat is in abundance. The present study has demonstrated that an ethanol extract of Lygodium flexuosum leaves extract has properties that render it capable of promoting accelerated wound healing activity compared with the controls. Wound contruction increased tensile strength, increased hydroxyproline content. It is used in externel application for rheumatism, sprains, scabies, eczema and cut wounds, they are reported to be particularly useful for carbuncles, reduce inflammation and acts as pancea for wounds, treat ulcer, various respiratory diseases, general disorder, muscles sprains. In pharmacological studies wound healing activity was done and it was observed that topically administred drugs are effective in faster wound contraction due to the larger availability at the wound site. A significant increase in wound contraction was seen in both does of ELF compared to control. Hence it appears that ELF has prohealing effect.
Keywords
wound healing
Lygodium flexuosum
Lygodiaceae
1.
Mohammed Wasiullah. In Vivo Study Wound Healing Potential (Incision) of Herbal Formulation. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2020 Aug. 2 [cited 2026 Apr. 16];2(4):439-47. Available from: https://ijamscr.com/ijamscr/article/view/116
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References
-
Astin, J.A., 1988. why patients use alternative medicine, results of a national study. JAMA, Vol. 279. pp. 1548–1553.
[2] Ali, Mohammed., 2007. Text book of pharmacognosy. CBS publishers, New Delhi. 2nd ed, pp. 9.
[3] Anonymous, “The Wealth of India, Raw Materials”, Publication and Information Directorate, CSSIR, New Delhi, 1993, Vol.6: L-M, pp.199-200.
[4] Anonymus, “British Pharmacopoiea”, 2001. Vol. 2, London. pp. 2379.
[5] Jackson, P.B., 2005. Atlas of microscopy of medicinal plants, culinary herbs and spices. CBS publishers, New Delhi.
[6] Achari, B., Basu. K., Saha, C.R., Prakashi, S.C., 1986. A New Triterpene Ester, an Anthraquinone and Other Constituents of the Fern Lygodium flexuosum. Journal of Planta Med. Vol. 52, Issue 4. pp. 329-30.
[7] Achari, Basudev., 1990. Structure of Lygodinolide:a novel spiro furan prehydro phenanthrene derivatives from Lygodium flexuosum. Journal of Organic Chemistry. Vol. 55. pp. 4977-4978
[8] Diwan, P.V., Tilloo, L.D., Kulkarni, D.R., 1982. Influence of Tridax procumbens on wound healing. Indian Journal of Medical Research. Vol. 75. pp. 450-464.
[9] Dave, Pride. Symbiosis: cattle rearing in oil palm. Palm oil truth foundation.
[10] Dangol, D.R., 2008. Traditional uses of plants of common land and habitat in western Chitwan, Nepal. Journal of Institute of Agriculture and Animal Science.Vol.29. pp.71-78.
[11] Evans, W.C., 2002. Text book of pharmacognosy. Harcourt Brace, Asia.15th ed, pp 1-8, 55-95.
[12] Enoch, S., and Price, P., 2004. Cellular molecular and biochemical differences in the pathophysiology of healing between acute wounds, chronic wounds and wounds in the elderly. Worldwidewounds.com.
[13] Ehrlich, H.P., and Hunt, T.K., 1968. Effect of cortiosone and vitamin A on wound healing. Journal of Animal Surgery. Vol. 167. pp. 324-328.
[14] Eisenberg, D.M., Davis, R.B, and Ettner S.L., 1998. Trends in alternative medicine use in the United States. JAMA, Vol. 280. pp. 1569–1575.
[15] Foster, G., 1997. Biodiversity and human health’ Island Press, Washington D.C, USA. pp. 123-127.
[16] Ferriter Amy. A report from the Florida’s exotic pest plant council’s Lygodium task force. lygodium management plan for Florida. First edition. 2001. pp.14
[17] Federal register of government a rule by the animal and plant health inspection services. Journal of United States. 2009. pp. 74.
[18] Ansari, S.H., 2005-06. Standardization of crude drugs, Essentials of Pharmacognosy. 1st ed. pp. 14, 581.
[19] Atal, C.K., Sharma, M.L., Kaul, A., Khajuria, A., 1986. Immunomodulating agents of plant origin. Journal of Ethanopharmacology. Vol. 18. pp. 133-144.
[20] A report of Washington in June 2008.
[21] Aliyeva, E., Umur, S., Zafer, E., Acigoz, G., 2004. The effect of polylactide membranes on the levels of reactive oxygen species in periodontal flaps duringwound healing. Biomaterials. Vol. 25. pp. 4633–4637.
[22] Annala of the Entomological Society of America. 2005. Vol. 98, Issue 6. pp. 887-95.
[23] Bir, S. S., Verma, S.C., 1951-2009. Chromosome’s atlas of the Indian petridophytes. pp. 84.
[24] Bugwood blog center for invasive species and ecosystem health., 2008. Federal import quarantine order of climbing ferns lygodium flexuosum and lygodium microphyllum.
[25] Banerjee, R.D., Sen, S.P., 1947. Antibiotic activity of petridophytes. Journal of Economic Botany. Vol. 34, Issue 3. pp. 284-298.
References
Astin, J.A., 1988. why patients use alternative medicine, results of a national study. JAMA, Vol. 279. pp. 1548–1553.
[2] Ali, Mohammed., 2007. Text book of pharmacognosy. CBS publishers, New Delhi. 2nd ed, pp. 9.
[3] Anonymous, “The Wealth of India, Raw Materials”, Publication and Information Directorate, CSSIR, New Delhi, 1993, Vol.6: L-M, pp.199-200.
[4] Anonymus, “British Pharmacopoiea”, 2001. Vol. 2, London. pp. 2379.
[5] Jackson, P.B., 2005. Atlas of microscopy of medicinal plants, culinary herbs and spices. CBS publishers, New Delhi.
[6] Achari, B., Basu. K., Saha, C.R., Prakashi, S.C., 1986. A New Triterpene Ester, an Anthraquinone and Other Constituents of the Fern Lygodium flexuosum. Journal of Planta Med. Vol. 52, Issue 4. pp. 329-30.
[7] Achari, Basudev., 1990. Structure of Lygodinolide:a novel spiro furan prehydro phenanthrene derivatives from Lygodium flexuosum. Journal of Organic Chemistry. Vol. 55. pp. 4977-4978
[8] Diwan, P.V., Tilloo, L.D., Kulkarni, D.R., 1982. Influence of Tridax procumbens on wound healing. Indian Journal of Medical Research. Vol. 75. pp. 450-464.
[9] Dave, Pride. Symbiosis: cattle rearing in oil palm. Palm oil truth foundation.
[10] Dangol, D.R., 2008. Traditional uses of plants of common land and habitat in western Chitwan, Nepal. Journal of Institute of Agriculture and Animal Science.Vol.29. pp.71-78.
[11] Evans, W.C., 2002. Text book of pharmacognosy. Harcourt Brace, Asia.15th ed, pp 1-8, 55-95.
[12] Enoch, S., and Price, P., 2004. Cellular molecular and biochemical differences in the pathophysiology of healing between acute wounds, chronic wounds and wounds in the elderly. Worldwidewounds.com.
[13] Ehrlich, H.P., and Hunt, T.K., 1968. Effect of cortiosone and vitamin A on wound healing. Journal of Animal Surgery. Vol. 167. pp. 324-328.
[14] Eisenberg, D.M., Davis, R.B, and Ettner S.L., 1998. Trends in alternative medicine use in the United States. JAMA, Vol. 280. pp. 1569–1575.
[15] Foster, G., 1997. Biodiversity and human health’ Island Press, Washington D.C, USA. pp. 123-127.
[16] Ferriter Amy. A report from the Florida’s exotic pest plant council’s Lygodium task force. lygodium management plan for Florida. First edition. 2001. pp.14
[17] Federal register of government a rule by the animal and plant health inspection services. Journal of United States. 2009. pp. 74.
[18] Ansari, S.H., 2005-06. Standardization of crude drugs, Essentials of Pharmacognosy. 1st ed. pp. 14, 581.
[19] Atal, C.K., Sharma, M.L., Kaul, A., Khajuria, A., 1986. Immunomodulating agents of plant origin. Journal of Ethanopharmacology. Vol. 18. pp. 133-144.
[20] A report of Washington in June 2008.
[21] Aliyeva, E., Umur, S., Zafer, E., Acigoz, G., 2004. The effect of polylactide membranes on the levels of reactive oxygen species in periodontal flaps duringwound healing. Biomaterials. Vol. 25. pp. 4633–4637.
[22] Annala of the Entomological Society of America. 2005. Vol. 98, Issue 6. pp. 887-95.
[23] Bir, S. S., Verma, S.C., 1951-2009. Chromosome’s atlas of the Indian petridophytes. pp. 84.
[24] Bugwood blog center for invasive species and ecosystem health., 2008. Federal import quarantine order of climbing ferns lygodium flexuosum and lygodium microphyllum.
[25] Banerjee, R.D., Sen, S.P., 1947. Antibiotic activity of petridophytes. Journal of Economic Botany. Vol. 34, Issue 3. pp. 284-298.
[2] Ali, Mohammed., 2007. Text book of pharmacognosy. CBS publishers, New Delhi. 2nd ed, pp. 9.
[3] Anonymous, “The Wealth of India, Raw Materials”, Publication and Information Directorate, CSSIR, New Delhi, 1993, Vol.6: L-M, pp.199-200.
[4] Anonymus, “British Pharmacopoiea”, 2001. Vol. 2, London. pp. 2379.
[5] Jackson, P.B., 2005. Atlas of microscopy of medicinal plants, culinary herbs and spices. CBS publishers, New Delhi.
[6] Achari, B., Basu. K., Saha, C.R., Prakashi, S.C., 1986. A New Triterpene Ester, an Anthraquinone and Other Constituents of the Fern Lygodium flexuosum. Journal of Planta Med. Vol. 52, Issue 4. pp. 329-30.
[7] Achari, Basudev., 1990. Structure of Lygodinolide:a novel spiro furan prehydro phenanthrene derivatives from Lygodium flexuosum. Journal of Organic Chemistry. Vol. 55. pp. 4977-4978
[8] Diwan, P.V., Tilloo, L.D., Kulkarni, D.R., 1982. Influence of Tridax procumbens on wound healing. Indian Journal of Medical Research. Vol. 75. pp. 450-464.
[9] Dave, Pride. Symbiosis: cattle rearing in oil palm. Palm oil truth foundation.
[10] Dangol, D.R., 2008. Traditional uses of plants of common land and habitat in western Chitwan, Nepal. Journal of Institute of Agriculture and Animal Science.Vol.29. pp.71-78.
[11] Evans, W.C., 2002. Text book of pharmacognosy. Harcourt Brace, Asia.15th ed, pp 1-8, 55-95.
[12] Enoch, S., and Price, P., 2004. Cellular molecular and biochemical differences in the pathophysiology of healing between acute wounds, chronic wounds and wounds in the elderly. Worldwidewounds.com.
[13] Ehrlich, H.P., and Hunt, T.K., 1968. Effect of cortiosone and vitamin A on wound healing. Journal of Animal Surgery. Vol. 167. pp. 324-328.
[14] Eisenberg, D.M., Davis, R.B, and Ettner S.L., 1998. Trends in alternative medicine use in the United States. JAMA, Vol. 280. pp. 1569–1575.
[15] Foster, G., 1997. Biodiversity and human health’ Island Press, Washington D.C, USA. pp. 123-127.
[16] Ferriter Amy. A report from the Florida’s exotic pest plant council’s Lygodium task force. lygodium management plan for Florida. First edition. 2001. pp.14
[17] Federal register of government a rule by the animal and plant health inspection services. Journal of United States. 2009. pp. 74.
[18] Ansari, S.H., 2005-06. Standardization of crude drugs, Essentials of Pharmacognosy. 1st ed. pp. 14, 581.
[19] Atal, C.K., Sharma, M.L., Kaul, A., Khajuria, A., 1986. Immunomodulating agents of plant origin. Journal of Ethanopharmacology. Vol. 18. pp. 133-144.
[20] A report of Washington in June 2008.
[21] Aliyeva, E., Umur, S., Zafer, E., Acigoz, G., 2004. The effect of polylactide membranes on the levels of reactive oxygen species in periodontal flaps duringwound healing. Biomaterials. Vol. 25. pp. 4633–4637.
[22] Annala of the Entomological Society of America. 2005. Vol. 98, Issue 6. pp. 887-95.
[23] Bir, S. S., Verma, S.C., 1951-2009. Chromosome’s atlas of the Indian petridophytes. pp. 84.
[24] Bugwood blog center for invasive species and ecosystem health., 2008. Federal import quarantine order of climbing ferns lygodium flexuosum and lygodium microphyllum.
[25] Banerjee, R.D., Sen, S.P., 1947. Antibiotic activity of petridophytes. Journal of Economic Botany. Vol. 34, Issue 3. pp. 284-298.