Myxofibrosarcoma of the male breast – An infrequent neoplasm: A case report and comprehensive review
Corresponding Author(s) : Shagufta Qadri
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 2 No. 4 (2014): 2014 Volume 2- Issue -4
Abstract
Primary breast sarcoma is a rare type of malignancy arising from the mesenchymal tissue of the breast and represent less than 1% of all breast cancers. We report a rare case of myxofibrosarcoma in a 25 year old male patient, who presented with rapidly enlarging mass, in his right breast extending upto right axilla since 5 month, the patient also had history of right breast lumpectomy 2 years back. On the basis of history, clinical examination and fine needle aspiration cytology a provisional diagnosis of stromal sarcoma breast with myxoid change was made. However histopathological examination and the immunohistochemical analysis lead to a conclusive diagnosis of myxofibrosarcoma breast with local recurrence. Myxofibrosarcoma shows a predilection for multiple local recurrences, tendency of low-grade tumour to recur at higher grades and potential metastasis which emphasizes the need for accurate diagnosis and excision in specialized centres.
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[1] Angervall L, Kindblom GL, and Merck C, “Mixofibrosarcoma. A study of 30 cases,” Acta Pathologica et Microbiologica Scandinavica 1977;85:127–40.
[2] Campbell LB, Mowad CM Breast carcinomas in males: A case report and brief review of the literature Cutis, 2009;83:79–82.
[3] Mahalingam SB, Mahalingam K, Mc Donough S, Malignant Fibrous Histiocytoma in a Male Breast: A case Report. Journal of Clinical Oncology, 2011;20;29(24):682-4
[4] Anderson WF, Althuis MD, Brinton LA et al. Is male breast cancer similar or different than female breast cancer? Breast Cancer Res Treat. 2004;83:77–86.
[5] Cil T, Alintas A, Pasa S et al. Primary Spindle Cell Sarcoma of the Breast. Breast Care (Basel) 2008 july; 3(3):197-9.
[6] Dewan V, Darbyshir A, Sumathi V, et al. “Prognostic and Survival factors in Myxofibrosarcoma”, A Clinical Study. Sarcoma, vol 2012, article ID 830879, 5 pages.
[7] Mentzel T, Van den Berg E, Molenaar WM. “Myxofi-brosarcoma”. In: Fletcher CDM, Unni KK, Mertens F. World Health Organization classification of tumours. pathology and genetics. Tumours of soft tissue and bone, 2002 edn. IARC press: Lyon, 2004, pp 102–3
[8] Huang HY, Lal P, Qin J et al. “Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems,” Human Pathology2004; 35(5):612–21.
[9] Mentzel T, Calonje E, Wadden C et al. “Myxofibrosarcoma: clinicopathologic analysis of 75 cases with emphasis on the low-grade variant,” American Journal of Surgical Pathology 1996;20(4):391–405.
[10] Weiss SW, Goldblum JR. Enzinger and Weiss’s soft tissue tumors, 5th edition, 2008.
[11] Gronchi, S. Lo Vullo, Colombo C et al., “Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survival,” Annals of Surgery 2010;251(3):506–11.
[12] Muler JH, Paulino AF, Roulston D, and Baker LH, “Myxoid malignant fibrous histiocytoma with multiple primary sites,” Sarcoma 2002;6(1):51-5.
References
[2] Campbell LB, Mowad CM Breast carcinomas in males: A case report and brief review of the literature Cutis, 2009;83:79–82.
[3] Mahalingam SB, Mahalingam K, Mc Donough S, Malignant Fibrous Histiocytoma in a Male Breast: A case Report. Journal of Clinical Oncology, 2011;20;29(24):682-4
[4] Anderson WF, Althuis MD, Brinton LA et al. Is male breast cancer similar or different than female breast cancer? Breast Cancer Res Treat. 2004;83:77–86.
[5] Cil T, Alintas A, Pasa S et al. Primary Spindle Cell Sarcoma of the Breast. Breast Care (Basel) 2008 july; 3(3):197-9.
[6] Dewan V, Darbyshir A, Sumathi V, et al. “Prognostic and Survival factors in Myxofibrosarcoma”, A Clinical Study. Sarcoma, vol 2012, article ID 830879, 5 pages.
[7] Mentzel T, Van den Berg E, Molenaar WM. “Myxofi-brosarcoma”. In: Fletcher CDM, Unni KK, Mertens F. World Health Organization classification of tumours. pathology and genetics. Tumours of soft tissue and bone, 2002 edn. IARC press: Lyon, 2004, pp 102–3
[8] Huang HY, Lal P, Qin J et al. “Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems,” Human Pathology2004; 35(5):612–21.
[9] Mentzel T, Calonje E, Wadden C et al. “Myxofibrosarcoma: clinicopathologic analysis of 75 cases with emphasis on the low-grade variant,” American Journal of Surgical Pathology 1996;20(4):391–405.
[10] Weiss SW, Goldblum JR. Enzinger and Weiss’s soft tissue tumors, 5th edition, 2008.
[11] Gronchi, S. Lo Vullo, Colombo C et al., “Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survival,” Annals of Surgery 2010;251(3):506–11.
[12] Muler JH, Paulino AF, Roulston D, and Baker LH, “Myxoid malignant fibrous histiocytoma with multiple primary sites,” Sarcoma 2002;6(1):51-5.