Antihyperlipidemic Activity of Plectranthus Vettiveroides Roots
Corresponding Author(s) : Gayathri Nallathambi
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 9 No. 1 (2021): 2021 Volume - 9 Issue-1
Abstract
Plant based Natural ingredients are important in the prevention and treatment of a variety of diseases and disorders in humans. Hyperlipidemia is a key clinical cause in heart disease and diabetes. Plectranthus vettiveroides, a member of the Lamiaceae family, was discovered to have anti-inflammatory, antibacterial, and anti-cancer properties, as well as CNS depressant properties. The current research uses an in vivo animal model to look at its antihyperlipidemic function. Dexamethasone administration causes a substantial rise in serum cholesterol and triglyceride (TG) levels, as well as an increase in the atherogenic index, in rats. The treatment of dexamethasone-induced hyperlipidemia in rats with an ethanolic extract of P.vettiveroides root (200 and 400 mg/kg) showed substantial inhibition by keeping cholesterol, TGs, and other serum levels near average.
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References
2. Namdeo A. Plant cell elicitation for production of secondary metabolites: A review. Pharmacogn Rev 2007;1:69-79.
3. Wilson EC. Screening plants for new medicines. Biodiversity. Washington, DC: National Academy Press; 1988. p. 51.
4. Ghsatak A, Asthana OP. Recent trends in hyperlipoproteinemias and its pharmacotherapy. Indian J Pharmacol ; 1995;27:14-29.
5. Moss JN, Dajani E. Anti-hyperlipidemic agents. In: Turner RA, Hebborn P, editors. Screening Methods of Toxicology. Vol. 2. New York: Academic Press; 1971. p. 121.
6. Anonymous. Drug Index. New Delhi: Pass Publication Pvt. Ltd.; 1999. p. 482.
7. Haughton PJ, Raman A. Laboratory Handbook for the Fractionation of Natural Extracts. 1st ed. USA: Chapman and Hall; 1998. p. 22-52.
8. Sofowora A. Screening plants for bioactive agents. In: Medicinal plant and Traditional Medicine in Africa. 2nd ed. Ibadan: Spectrum Books Ltd.; 1993. p. 289.
9. Evans WC. An overview of drugs having antihepatotoxic and oral hypoglycaemic activities. In: Trease and Evans, Pharmacognosy. 14th ed. UK: Sanders Company Ltd.; 1996. p. 119-59.
10. Available from: http://www.cn.wikipedia.org/wiki/ dexamethasone.
11. Brader ED, Lee PC, Raff H. Dexamethasone treatment in the newborn rat: Fatty acid profiling of lung, brain and serum lipids. J Appl Physiol 2005;98:981-90.