Formulation, development and evaluation of mouth melting tablet of famotidine by using natural and synthetic superdisintegrants
Corresponding Author(s) : Archana Kumari
kumariarchana10295@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 9 No. 1 (2021): 2021 Volume - 9 Issue-1
Abstract
The Purpose of the present research was to prepare mouth melting tablet of Famotidine by using natural and synthetic superdisintegrants such as, ispaghula husk powder, croscarmilose, crospovidone . the objective to reduced patient compliance and the reduced onset action of due to fast pass metabolism. Tablets prepared by direct compression method. The powder mixtures prepared to both pre and post compression evaluation parameters such as micromeritics properties, tablets hardness, friability , wetting time , disintegration time and in –vitro drug release . The results of both pre and post formulations were of acceptable to good flow ability and in-vitro release determine different model viz. zero order, first order, Hixson-Crowell equation, Higuchi model & Korsmeyer-peppas model indicate that formulation F3 found to be the best fit Korsmeyer-peppas model.
Keywords
Mouth dissolving tablets
mouth melting tablets
Fast disintegrating tablets
Direct compression
Wetting time
superdisintegrants
1.
Dr. Mayank Bansal, Archana Kumari, Mr. Jitender Kumar. Formulation, development and evaluation of mouth melting tablet of famotidine by using natural and synthetic superdisintegrants. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2021 Feb. 18 [cited 2026 Jan. 13];9(1):21-35. Available from: https://ijamscr.com/ijamscr/article/view/961
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References
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15. Chang, R., Guo, X., Burnside, B. A., Couch, R., 2000. Fast-Dissolving Tablets. Pharmaceutical Technology, Vol. 24, Issue 6,pp.52-58.
16. Changoiwalan, Dr. Gokhle, M.C., Krupam, Modi, S. C., Dr. Parikh, R. K., 2012. Formulation, Development & Optimization of Orodispersible tablet of Cetirizine hydrochloride. International Journal of Pharmaceutical Research & Bio-Science, Vol. 1, Issue 6, pp.218-238.
17. Chaudhary, S. A., Chaudhary, A. B., Mehta, T. A., 2010. Excipients Updates for Orally Disintegrating Dosage Forms. Int. J. Res. Pharm. Sci., Vol. 1, Issue 2, pp.103-107.
18. Cirri, M., Valleri, M., Mura, P., Maestrelli, F., Ballerini, R., Development of fast-dissolving tablets of flurbiprofen cyclodextrin complexes. Drug Dev Ind. Pharm. ,Vol. 3 Issue 1, pp.697-707.
19. Dekivadia, M., Gudigennavar, A., Patil, C., Bhaskar, U., 2012. Development & optimization of fast Dissolving tablet of levocetirizine HCL. International Journal of Drug Development & Research, Vol. 4, Issue 2,pp.237-246.
20. Deshmukh, H., Chandrasekhar, S., Nagesh, C., Murade, A., Usgaunkar, S., 2012. Superdisintegrants: A Recent Investigation and Current Approach. Asian J. Pharm. Tech, Vol. 2, Issue 1, pp.19-25.
21. Devi, V. K., Asha, A. N., Rai, R. S., Reddy, M., Raghavendra, M., 2008. Orodispersible Fluconazole tablet-preparation and Evaluation. Indian Drugs, Vol. 43, Issue 7, pp.548-52.
22. Dahima, R., Sahare, M., 2018. Formulation And In-Vitro Evaluation Of Gastro Retentive Bilayer Floating Tablet Of Famotidine Hydrochloride. Journal of Drug Delivery & Therapeutics. Vol, 8, Issue 4 pp 314-319.
23. Donthi, M, R., Dudhipala, N, R., Komalla, D, R., Dinesh, S., Banala, N., 2015. Preparation and Evaluation of Fixed Combination of Ketoprofen Enteric Coated and Famotidine Floating Mini Tablets by Single Unit Encapsulation System. Journal of Bioequivalence & Bioavailability. Vol. 7, Issue 6, pp. 279.
24. Gandhi, G. S., Dharmendra, R., Mundhada and Bhaskaran, S., 2011. Levocetirizine orodispersible tablet by direct compression method, Journal of Applied Pharmaceutical Science, Vol. 1, Issue 5, pp. 145-150.
25. Ganure, A., Dangi, A., Patel, P., Rai, M., Aravadiya, J., 2011. Preparation & Evaluation of Tramadol Hydrochloride Fast Dissolving Tablet by using Direct Compression technique. IJPI Vol. 1, Issue 2, pp. 33-42.
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