Date Log
Submitted
February 1, 2021
Published
February 1, 2021
Fast-Disintegrating Tablets: A Short Review
Corresponding Author(s) : Ms. Afrin Alam
afrinalam098@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 4 (2020): 2020 Volume - 8 Issue-4
Abstract
The convenience of administration along with improved patient compliance is important in the development of oral drug delivery system that remains the favored route of drug delivery inspite of a range of disadvantages. One among problem can be solved in this novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) that disintegrates or dissolves quickly without water within few seconds inside the mouth due to the act of superdisintegrant or maximizing pore structure in the formulation. These mouth dissolving tablets are advantageous mainly for pediatric, geriatric and mentally ill patients who have complexity in swallowing conventional tablets and capsules units. This review describes the various formulation aspects, superdisintegrants engaged and technologies developed for MDTs, along with various excipients, evaluation tests..
Keywords
Fast-disintegrating tablet
Sublimation
Dissolving Tablets
MDT
Ms. Afrin Alam, Mr. Sushil Agarwal, Dr. Naveen Singhal, Mr. Yogesh Kumar Garg, & Mr. Jitendra Kumar. (2021). Fast-Disintegrating Tablets: A Short Review. International Journal of Allied Medical Sciences and Clinical Research, 8(4), 797–806. https://doi.org/10.61096/ijamscr.v8.iss4.2020.797-806
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References
-
1. Abdelbary G, Prinderre P, Eouani C, Joachim J, Reynier JP, Piccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int J Pharm 2004; 278:423-33.
2. Aher S, Saudagar R, Chaudhari D, Formulation and evaluation of taste masked fast dissolving tablet of prazosin hydrochloride, Journal of Drug Delivery and Therapeutics.
3. Allen LV, Wang B. Process for making a particulate support matrix for making a rapidly dissolving tablet. US Patent 5,587,180; 1996.
4. Allen LV, Wang B, Davis LD. Rapidly dissolving tablet. US Patent 5,807,576; 1998.
5. Allen LV, Wang B. Process for making a particulate support matrix for making a rapidly dissolving dosage form. US Patent 6,207,199; 2001.
6. Bhaskaran S, Narmada GV. Rapid Dissolving tablet A Novel dosage form Indian Pharmacist 2002; 1:9-12.
7. Bi Y, Sunada H, Yonezawa Y, Dayo K, Otsuka A, Iida K. Preparation and evaluation of compressed tablet rapidly disintegrating in oral cavity. Chem Pharm Bull (Tokyo)1996; 44:2121-2127.
8. Bolhuis KG, Zuurman, Wrierikte PHG etal Eru.J.Pharm 1997; 5:63.
9. Cheng R, Guo X, Burusid B, Couch R.A review of fast dissolving tablets. Pharm Tech, (North America). June, 2000; 52-58
10. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste- masking and clinical studies. Crit Rev Ther Drug Carrier Sys 2004; 21:433-76.
11. Fu, Y., Yang, S., Jeong, S. H., Kimura, S., Park, K., Therapeutic Drug Carrier Systems, Orally Fast Disintegrating Tablets: Developments, Technologies, Taste- Masking and Clinical Studies; Critical Reviews™ in Therapeutic Drug Carrier Systems,2004; 21(6):433–475
12. Garg A, Gupta M, Mouth dissolving tablets: a review. Journal of Drug Delivery and Therapeutics, 2013; 3(2):207-214. doi:10.22270/jddt.v3i2.458.
13. Garg A, Gupta M, Taste masking and formulation development & evaluation of mouth dissolving tablets of levocetrizine dihydrochloride. Journal of Drug Delivery and Therapeutics, 2013; 3(3):123-130.
14. Gohel M, Patel M, Amin A, Agarwal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolving tablets of nimesulide using vacuum drying technique. AAPS Pharm Sci Tech 2004; 5: Article 36.
15. Habib W, Khankari RK, Hontz J. Fast-dissolve drug delivery systems. Crit Rev Ther Drug Carrier Sys 2000; 17:61-72.
16. Hardenia S., Darwhekar G. Formulation and optimization of fast dissolving tablets of promethazine theoclate using 32 factorial design. Journal of Drug Delivery and Therapeutics, 2017; 7(7):12-14.
17. Heinemann Hand Rotte W. US Patent 1976;3, 885,026.
18. Kakade S.M, Mannur V.S, Kardi R.V, Ramani K.B, Dhada A.A. Formulation and Evaluation of Orally Disintegrating Tablets of Sertraline. Inter. J. Pharma Res. Development.2010; 1(12):1-7.
19. Keshari A., Tripathi, D. P., Srivastava A., Vishwas R. Formulation and evaluation of effervecent floating tablets of antidiabetic drug. Journal of Drug Delivery and Therapeutics, 2015; 5(6):43-55. https://doi.org/10.22270/jddt.v5i6.1176.
20. Kintsch KN,Hagen A, Manz E . US Patent1979; 4,134,943.
21. Koizumi K, Watanabe Y, Morita K, Utoguchi N, Matsumoto M. New method of preparing highporosity rapidly saliva soluble compressed tablets using mannitol with camphor: A subliming material. Int J Pharm 1997; 152:127-31.
22. Kundu S, Sahoo P. K. Recent Trends in The Developments of Orally Disintegrating Tablet Technology. Pharma Times.2008; 40(4):11-15.
23. Kuno Y, Kojima M, Ando S, Nakagami H. Evaluation of rapidly disintegrating tablets anufactured by phase transition of sugar alcohols. J Control Release 2005; 105:16-22.
24. Mallika,T., Anand,D., Harikrishna,E. Isolation, characterization and investigation of starch phthalate as novel superdisintegrant in developing of acyclovir fast dissolving tablets. Journal of Drug Delivery and Therapeutics, 2018; 8(1):33-42. https://doi.org/10.22270/jddt.v8i1.1550.
25. Manivannan R. Oral disintegrating tablets: a future compaction. Inter. J. Pharma Res. Development.2009; 1(10):1-10.
26. Mohire N.C, Yadav A.V, Gaikwad V. K. Novel Approaches in Development of Metronidazole Orodispersible Tablets. Research J. Pharm. and Tech.2009; 2(2):283-286.
27. Mudgal, V. K., Sethi, P., Kheri, R., Saraogi, G.K., Singhai,A.K., Orally Disintegrating Tablets: A Review,Int. Research J. Pharmacy, 2011; 2(4):16-22
28. Makino T, Yamad M, Kikutaj,et al US Patent1998; 5,939,091.
29. Meyers GL, Battist GE, Fuisz RC. Process and apparatus for making rapidly dissolving dosage units and product there form. PCT Patent WC 95/34293- A1; 1995.
30. Panigrahi D, Baghel S, Mishra B. Mouth dissolving tablet: An overview of preparation techniques, evalution and patented technologies. Journal of pharmaceutical research. July 2005, vol.4, no.3: 33-38.
31. Quick dissolving tablets. http:/www.biospace.com
32. Ravichandiran V, Masilamani V, Kumar SS, Kumaragurubaran T, Senthilnathan B, Kamalakkannan V. Fast Dissolving Tablets: A Review, Journal of Pharmacy Research. 2011; 4(8):2590-2592.
33. Rishi RK, The pharma review 2004;2:32
34. Siraj S., Kausar S., Khan G., Khan T. Formulation and evaluation of oral fast dissolving tablet of ondansetron hydrochloride by coprocess excipients. Journal of Drug Delivery and Therapeutics, 2017; 7(5):102-108. https://doi.org/10.22270/jddt.v7i5.1498.
35. Sharma N, Sharma J, Jat RC, Rathore AS, Fast is dissolving tablets as novel dosage form, International Journal of Research and Development in Pharmacy and Life Sciences. 2012; 1(3):90-104.
36. Shaikh S,.Khirsagar R.V, Quazi A. Fast Disintegrating Tablets: An Overview Of Formulation And Technology. Inter J. Pharmacy Pharma Sci.2010; 2(3):9-15
37. Suresh Bandari, Rajendar kumar Mitta palli, Ramesh Gannu, Yamsani Madhusudan Rao. Orodispersible tablets: An overview. Asian Journal of pharmaceutics. Jan 2008.
38. Van Scoik KG. Solid Pharmaceutical dosage in tablet triturates form and method of producing the same. US Patent 5,082, 667.
References
1. Abdelbary G, Prinderre P, Eouani C, Joachim J, Reynier JP, Piccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int J Pharm 2004; 278:423-33.
2. Aher S, Saudagar R, Chaudhari D, Formulation and evaluation of taste masked fast dissolving tablet of prazosin hydrochloride, Journal of Drug Delivery and Therapeutics.
3. Allen LV, Wang B. Process for making a particulate support matrix for making a rapidly dissolving tablet. US Patent 5,587,180; 1996.
4. Allen LV, Wang B, Davis LD. Rapidly dissolving tablet. US Patent 5,807,576; 1998.
5. Allen LV, Wang B. Process for making a particulate support matrix for making a rapidly dissolving dosage form. US Patent 6,207,199; 2001.
6. Bhaskaran S, Narmada GV. Rapid Dissolving tablet A Novel dosage form Indian Pharmacist 2002; 1:9-12.
7. Bi Y, Sunada H, Yonezawa Y, Dayo K, Otsuka A, Iida K. Preparation and evaluation of compressed tablet rapidly disintegrating in oral cavity. Chem Pharm Bull (Tokyo)1996; 44:2121-2127.
8. Bolhuis KG, Zuurman, Wrierikte PHG etal Eru.J.Pharm 1997; 5:63.
9. Cheng R, Guo X, Burusid B, Couch R.A review of fast dissolving tablets. Pharm Tech, (North America). June, 2000; 52-58
10. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste- masking and clinical studies. Crit Rev Ther Drug Carrier Sys 2004; 21:433-76.
11. Fu, Y., Yang, S., Jeong, S. H., Kimura, S., Park, K., Therapeutic Drug Carrier Systems, Orally Fast Disintegrating Tablets: Developments, Technologies, Taste- Masking and Clinical Studies; Critical Reviews™ in Therapeutic Drug Carrier Systems,2004; 21(6):433–475
12. Garg A, Gupta M, Mouth dissolving tablets: a review. Journal of Drug Delivery and Therapeutics, 2013; 3(2):207-214. doi:10.22270/jddt.v3i2.458.
13. Garg A, Gupta M, Taste masking and formulation development & evaluation of mouth dissolving tablets of levocetrizine dihydrochloride. Journal of Drug Delivery and Therapeutics, 2013; 3(3):123-130.
14. Gohel M, Patel M, Amin A, Agarwal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolving tablets of nimesulide using vacuum drying technique. AAPS Pharm Sci Tech 2004; 5: Article 36.
15. Habib W, Khankari RK, Hontz J. Fast-dissolve drug delivery systems. Crit Rev Ther Drug Carrier Sys 2000; 17:61-72.
16. Hardenia S., Darwhekar G. Formulation and optimization of fast dissolving tablets of promethazine theoclate using 32 factorial design. Journal of Drug Delivery and Therapeutics, 2017; 7(7):12-14.
17. Heinemann Hand Rotte W. US Patent 1976;3, 885,026.
18. Kakade S.M, Mannur V.S, Kardi R.V, Ramani K.B, Dhada A.A. Formulation and Evaluation of Orally Disintegrating Tablets of Sertraline. Inter. J. Pharma Res. Development.2010; 1(12):1-7.
19. Keshari A., Tripathi, D. P., Srivastava A., Vishwas R. Formulation and evaluation of effervecent floating tablets of antidiabetic drug. Journal of Drug Delivery and Therapeutics, 2015; 5(6):43-55. https://doi.org/10.22270/jddt.v5i6.1176.
20. Kintsch KN,Hagen A, Manz E . US Patent1979; 4,134,943.
21. Koizumi K, Watanabe Y, Morita K, Utoguchi N, Matsumoto M. New method of preparing highporosity rapidly saliva soluble compressed tablets using mannitol with camphor: A subliming material. Int J Pharm 1997; 152:127-31.
22. Kundu S, Sahoo P. K. Recent Trends in The Developments of Orally Disintegrating Tablet Technology. Pharma Times.2008; 40(4):11-15.
23. Kuno Y, Kojima M, Ando S, Nakagami H. Evaluation of rapidly disintegrating tablets anufactured by phase transition of sugar alcohols. J Control Release 2005; 105:16-22.
24. Mallika,T., Anand,D., Harikrishna,E. Isolation, characterization and investigation of starch phthalate as novel superdisintegrant in developing of acyclovir fast dissolving tablets. Journal of Drug Delivery and Therapeutics, 2018; 8(1):33-42. https://doi.org/10.22270/jddt.v8i1.1550.
25. Manivannan R. Oral disintegrating tablets: a future compaction. Inter. J. Pharma Res. Development.2009; 1(10):1-10.
26. Mohire N.C, Yadav A.V, Gaikwad V. K. Novel Approaches in Development of Metronidazole Orodispersible Tablets. Research J. Pharm. and Tech.2009; 2(2):283-286.
27. Mudgal, V. K., Sethi, P., Kheri, R., Saraogi, G.K., Singhai,A.K., Orally Disintegrating Tablets: A Review,Int. Research J. Pharmacy, 2011; 2(4):16-22
28. Makino T, Yamad M, Kikutaj,et al US Patent1998; 5,939,091.
29. Meyers GL, Battist GE, Fuisz RC. Process and apparatus for making rapidly dissolving dosage units and product there form. PCT Patent WC 95/34293- A1; 1995.
30. Panigrahi D, Baghel S, Mishra B. Mouth dissolving tablet: An overview of preparation techniques, evalution and patented technologies. Journal of pharmaceutical research. July 2005, vol.4, no.3: 33-38.
31. Quick dissolving tablets. http:/www.biospace.com
32. Ravichandiran V, Masilamani V, Kumar SS, Kumaragurubaran T, Senthilnathan B, Kamalakkannan V. Fast Dissolving Tablets: A Review, Journal of Pharmacy Research. 2011; 4(8):2590-2592.
33. Rishi RK, The pharma review 2004;2:32
34. Siraj S., Kausar S., Khan G., Khan T. Formulation and evaluation of oral fast dissolving tablet of ondansetron hydrochloride by coprocess excipients. Journal of Drug Delivery and Therapeutics, 2017; 7(5):102-108. https://doi.org/10.22270/jddt.v7i5.1498.
35. Sharma N, Sharma J, Jat RC, Rathore AS, Fast is dissolving tablets as novel dosage form, International Journal of Research and Development in Pharmacy and Life Sciences. 2012; 1(3):90-104.
36. Shaikh S,.Khirsagar R.V, Quazi A. Fast Disintegrating Tablets: An Overview Of Formulation And Technology. Inter J. Pharmacy Pharma Sci.2010; 2(3):9-15
37. Suresh Bandari, Rajendar kumar Mitta palli, Ramesh Gannu, Yamsani Madhusudan Rao. Orodispersible tablets: An overview. Asian Journal of pharmaceutics. Jan 2008.
38. Van Scoik KG. Solid Pharmaceutical dosage in tablet triturates form and method of producing the same. US Patent 5,082, 667.
2. Aher S, Saudagar R, Chaudhari D, Formulation and evaluation of taste masked fast dissolving tablet of prazosin hydrochloride, Journal of Drug Delivery and Therapeutics.
3. Allen LV, Wang B. Process for making a particulate support matrix for making a rapidly dissolving tablet. US Patent 5,587,180; 1996.
4. Allen LV, Wang B, Davis LD. Rapidly dissolving tablet. US Patent 5,807,576; 1998.
5. Allen LV, Wang B. Process for making a particulate support matrix for making a rapidly dissolving dosage form. US Patent 6,207,199; 2001.
6. Bhaskaran S, Narmada GV. Rapid Dissolving tablet A Novel dosage form Indian Pharmacist 2002; 1:9-12.
7. Bi Y, Sunada H, Yonezawa Y, Dayo K, Otsuka A, Iida K. Preparation and evaluation of compressed tablet rapidly disintegrating in oral cavity. Chem Pharm Bull (Tokyo)1996; 44:2121-2127.
8. Bolhuis KG, Zuurman, Wrierikte PHG etal Eru.J.Pharm 1997; 5:63.
9. Cheng R, Guo X, Burusid B, Couch R.A review of fast dissolving tablets. Pharm Tech, (North America). June, 2000; 52-58
10. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste- masking and clinical studies. Crit Rev Ther Drug Carrier Sys 2004; 21:433-76.
11. Fu, Y., Yang, S., Jeong, S. H., Kimura, S., Park, K., Therapeutic Drug Carrier Systems, Orally Fast Disintegrating Tablets: Developments, Technologies, Taste- Masking and Clinical Studies; Critical Reviews™ in Therapeutic Drug Carrier Systems,2004; 21(6):433–475
12. Garg A, Gupta M, Mouth dissolving tablets: a review. Journal of Drug Delivery and Therapeutics, 2013; 3(2):207-214. doi:10.22270/jddt.v3i2.458.
13. Garg A, Gupta M, Taste masking and formulation development & evaluation of mouth dissolving tablets of levocetrizine dihydrochloride. Journal of Drug Delivery and Therapeutics, 2013; 3(3):123-130.
14. Gohel M, Patel M, Amin A, Agarwal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolving tablets of nimesulide using vacuum drying technique. AAPS Pharm Sci Tech 2004; 5: Article 36.
15. Habib W, Khankari RK, Hontz J. Fast-dissolve drug delivery systems. Crit Rev Ther Drug Carrier Sys 2000; 17:61-72.
16. Hardenia S., Darwhekar G. Formulation and optimization of fast dissolving tablets of promethazine theoclate using 32 factorial design. Journal of Drug Delivery and Therapeutics, 2017; 7(7):12-14.
17. Heinemann Hand Rotte W. US Patent 1976;3, 885,026.
18. Kakade S.M, Mannur V.S, Kardi R.V, Ramani K.B, Dhada A.A. Formulation and Evaluation of Orally Disintegrating Tablets of Sertraline. Inter. J. Pharma Res. Development.2010; 1(12):1-7.
19. Keshari A., Tripathi, D. P., Srivastava A., Vishwas R. Formulation and evaluation of effervecent floating tablets of antidiabetic drug. Journal of Drug Delivery and Therapeutics, 2015; 5(6):43-55. https://doi.org/10.22270/jddt.v5i6.1176.
20. Kintsch KN,Hagen A, Manz E . US Patent1979; 4,134,943.
21. Koizumi K, Watanabe Y, Morita K, Utoguchi N, Matsumoto M. New method of preparing highporosity rapidly saliva soluble compressed tablets using mannitol with camphor: A subliming material. Int J Pharm 1997; 152:127-31.
22. Kundu S, Sahoo P. K. Recent Trends in The Developments of Orally Disintegrating Tablet Technology. Pharma Times.2008; 40(4):11-15.
23. Kuno Y, Kojima M, Ando S, Nakagami H. Evaluation of rapidly disintegrating tablets anufactured by phase transition of sugar alcohols. J Control Release 2005; 105:16-22.
24. Mallika,T., Anand,D., Harikrishna,E. Isolation, characterization and investigation of starch phthalate as novel superdisintegrant in developing of acyclovir fast dissolving tablets. Journal of Drug Delivery and Therapeutics, 2018; 8(1):33-42. https://doi.org/10.22270/jddt.v8i1.1550.
25. Manivannan R. Oral disintegrating tablets: a future compaction. Inter. J. Pharma Res. Development.2009; 1(10):1-10.
26. Mohire N.C, Yadav A.V, Gaikwad V. K. Novel Approaches in Development of Metronidazole Orodispersible Tablets. Research J. Pharm. and Tech.2009; 2(2):283-286.
27. Mudgal, V. K., Sethi, P., Kheri, R., Saraogi, G.K., Singhai,A.K., Orally Disintegrating Tablets: A Review,Int. Research J. Pharmacy, 2011; 2(4):16-22
28. Makino T, Yamad M, Kikutaj,et al US Patent1998; 5,939,091.
29. Meyers GL, Battist GE, Fuisz RC. Process and apparatus for making rapidly dissolving dosage units and product there form. PCT Patent WC 95/34293- A1; 1995.
30. Panigrahi D, Baghel S, Mishra B. Mouth dissolving tablet: An overview of preparation techniques, evalution and patented technologies. Journal of pharmaceutical research. July 2005, vol.4, no.3: 33-38.
31. Quick dissolving tablets. http:/www.biospace.com
32. Ravichandiran V, Masilamani V, Kumar SS, Kumaragurubaran T, Senthilnathan B, Kamalakkannan V. Fast Dissolving Tablets: A Review, Journal of Pharmacy Research. 2011; 4(8):2590-2592.
33. Rishi RK, The pharma review 2004;2:32
34. Siraj S., Kausar S., Khan G., Khan T. Formulation and evaluation of oral fast dissolving tablet of ondansetron hydrochloride by coprocess excipients. Journal of Drug Delivery and Therapeutics, 2017; 7(5):102-108. https://doi.org/10.22270/jddt.v7i5.1498.
35. Sharma N, Sharma J, Jat RC, Rathore AS, Fast is dissolving tablets as novel dosage form, International Journal of Research and Development in Pharmacy and Life Sciences. 2012; 1(3):90-104.
36. Shaikh S,.Khirsagar R.V, Quazi A. Fast Disintegrating Tablets: An Overview Of Formulation And Technology. Inter J. Pharmacy Pharma Sci.2010; 2(3):9-15
37. Suresh Bandari, Rajendar kumar Mitta palli, Ramesh Gannu, Yamsani Madhusudan Rao. Orodispersible tablets: An overview. Asian Journal of pharmaceutics. Jan 2008.
38. Van Scoik KG. Solid Pharmaceutical dosage in tablet triturates form and method of producing the same. US Patent 5,082, 667.
