Drug Delivery System as Colon Targeting: an Overview
Corresponding Author(s) : Sourabh Girdhar
sourabhgirdhar141@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 4 (2020): 2020 Volume - 8 Issue-4
Abstract
The oral route is measured to be the most preferred route for administration of drugs for systemic effect, but the oral route is not appropriate to the administration of drug for lower gastrointestinal (GI) diseases, this happened due to their release at upper GI tract (stomach, small intestine), which further minimizes the convenience of drugs at the lower GI tract. To overcome this complexity, colon-specific drug delivery systems have been largely analyzed throughout the last two decades. Colonic drug delivery has gained increased significance not just for the delivery of the drugs for the cure of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, etc. but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs, and anti-diabetic agents. This review article discusses, in concise, the introduction of the colon, factor affecting the colonic transition, colonic diseases and the novel and rising technologies for colon targeting. Major approaches for Colon Colon targeted Drug Delivery System, which include prodrugs, pH and time dependent systems, Bacterial enzyme dependent colonic Drug Delivery System and pH and bacterial enzyme dependent colonic Drug Delivery System. The novel approach of CTDDS, which includes pressure controlled colonic delivery capsules, osmotic controlled drug delivery are precise technique..
Keywords
Novel approaches
evaluation of colon targeted drug delivery systems (CTDDS)
1.
Yogesh kumarGarg, Sourabh Girdhar, Dr.Naveen Singhal. Drug Delivery System as Colon Targeting: an Overview. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2021 Jan. 25 [cited 2026 Apr. 19];8(4):774-80. Available from: https://ijamscr.com/ijamscr/article/view/951
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References
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1. Abdul B, John B; 2003 Perspectives on Colonic Drug Delivery, Business Briefing Pharmatech, 185-190.
2. A. Martin, 1993; Buffered and Isotonic Solutions, Physical Pharmacy, Lippincott Williams and Wilkins, Baltimore,. pp. 169–189.
3. Akala EO, Elekwachi O, Chase V, Johnson H, Lazarre M, Scott K. Organic redox-initiated polymerization process for the fabrication of hydrogels for colon-specific drug delivery. Drug Dev Ind Pharm 2003 Apr;29(4):375-386.
4. Armand, J.Y., magnard, F., Bozon, J., Rollet, J., Taverdet, J.L., Vergnaud, J.M., 1987. Modelling of drug release in gastric liquid from galenic forms with Eudragit matrix. Int. J. Pharm. 40, 33–41.
5. Ashford, M., Fell, J.T., Attwood, D., Sharma, H.,Woodhead, P.J., 1993. An in vivo investigation into the suitability of pH dependent polymers for colonic targeting. Int.J. Pharm. 95, 193–199.
6. Basit A, Bloor J. Prespectives on colonic drug delivery, Business briefing. Pharmtech 2003; 185-190.
7. Brahamankar BM, Jaiswal SB; 1995.Biopharmaceutics and pharmacokinetics to controlled release medication of oral site specific / colon DDS, 457.
8. Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Pharm Sci 2003 Jan-Apr;6(1):33-66.
9. Chien YW. Oral drug delivery and delivery systems. In: Chien YW, editor. Novel drug delivery systems. New York: Marcel Dekker Inc; 1992; 139-196.
10. Dew M.J.; Hughes P.J.; Lee M.G.; Evans B.K. and Rhodes J; 1982.An Oral preparation to release drug in human colon. BR. .14:405-408.
11. FARA, J.W. 1989.Colonic drug absorption and metabolism, In: Novel Drug Delivery and its Therapeutic Applications, Eds, Prescott, L.F. and Nimmo, W.S. Wiley, Chichester, 103.
12. FLORY, P.J. (ED.), 1953. Principles of Polymer Chemistry. Cornell University, Ithaca, New York.
13. JOHN G. HARDY, Scintigraphic techniques in studying colon drug absorption, In: Peter R.Bieck, Editor“ Colonic drug absorption and metabolism” Marcel dekker Inc; vol-60 :70-104.
14. KARANJIT KAUR, KWONHO KIM; 2009 Studies of chitosan/organic acid/Eudragit® RS/RL-coated system for colonic delivery International Journal of Pharmaceutics 366, 140–148.
15. OKOR, R.S., 1982. Effect of polymer cation content on certain film properties. J. Pharm. Pharmacol. 34, 83–86.
16. Oluwatoyin AO, John TF. In vitro evaluation of khaya and albizia gums as compression coating for drug targeting to the colon. J Pharm Pharmacol 2005;57:63-168.
17. Philip AK, Dabas S, Pathak K. Optimized prodrug approach: a means for achieving enhanced anti-inflammatory potential in experimentally induced colitis. J Drug Target 2009 Apr;17(3):235-241.
18. REDDY MS, SINHA RV, REDDY DS; 1999. Colon targeted systems. Drugs Today; 35(7):537.
19. THREVEEN C, VINAY V., KRISHNA V.A; 2011, Colon specific drug delivery systems: a review on primary and novel approaches, IJPSRR, article-031
20. Watts P, Illum L. Colonic drug delivery. Drug Dev Ind Pharm 1997;23:893- 913 .
21. Wood E, Wilson CG, Hardy JG. The spreading of foam and solution enemas. Int J Pharm 1985;25:191-197 .
22. WU, C., MCGINITY, J.W., 1999. Non-traditional plasticization of polymeric films. Int. J.Pharm. 177, 15–27.
23. YASUDA, H., LAMAZE, C.E., 1971. Perms electivity of solutes in homogeneous water swollen polymer membranes. J. Macromol. Sci. Phys. B5 11, 111–134.
References
1. Abdul B, John B; 2003 Perspectives on Colonic Drug Delivery, Business Briefing Pharmatech, 185-190.
2. A. Martin, 1993; Buffered and Isotonic Solutions, Physical Pharmacy, Lippincott Williams and Wilkins, Baltimore,. pp. 169–189.
3. Akala EO, Elekwachi O, Chase V, Johnson H, Lazarre M, Scott K. Organic redox-initiated polymerization process for the fabrication of hydrogels for colon-specific drug delivery. Drug Dev Ind Pharm 2003 Apr;29(4):375-386.
4. Armand, J.Y., magnard, F., Bozon, J., Rollet, J., Taverdet, J.L., Vergnaud, J.M., 1987. Modelling of drug release in gastric liquid from galenic forms with Eudragit matrix. Int. J. Pharm. 40, 33–41.
5. Ashford, M., Fell, J.T., Attwood, D., Sharma, H.,Woodhead, P.J., 1993. An in vivo investigation into the suitability of pH dependent polymers for colonic targeting. Int.J. Pharm. 95, 193–199.
6. Basit A, Bloor J. Prespectives on colonic drug delivery, Business briefing. Pharmtech 2003; 185-190.
7. Brahamankar BM, Jaiswal SB; 1995.Biopharmaceutics and pharmacokinetics to controlled release medication of oral site specific / colon DDS, 457.
8. Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Pharm Sci 2003 Jan-Apr;6(1):33-66.
9. Chien YW. Oral drug delivery and delivery systems. In: Chien YW, editor. Novel drug delivery systems. New York: Marcel Dekker Inc; 1992; 139-196.
10. Dew M.J.; Hughes P.J.; Lee M.G.; Evans B.K. and Rhodes J; 1982.An Oral preparation to release drug in human colon. BR. .14:405-408.
11. FARA, J.W. 1989.Colonic drug absorption and metabolism, In: Novel Drug Delivery and its Therapeutic Applications, Eds, Prescott, L.F. and Nimmo, W.S. Wiley, Chichester, 103.
12. FLORY, P.J. (ED.), 1953. Principles of Polymer Chemistry. Cornell University, Ithaca, New York.
13. JOHN G. HARDY, Scintigraphic techniques in studying colon drug absorption, In: Peter R.Bieck, Editor“ Colonic drug absorption and metabolism” Marcel dekker Inc; vol-60 :70-104.
14. KARANJIT KAUR, KWONHO KIM; 2009 Studies of chitosan/organic acid/Eudragit® RS/RL-coated system for colonic delivery International Journal of Pharmaceutics 366, 140–148.
15. OKOR, R.S., 1982. Effect of polymer cation content on certain film properties. J. Pharm. Pharmacol. 34, 83–86.
16. Oluwatoyin AO, John TF. In vitro evaluation of khaya and albizia gums as compression coating for drug targeting to the colon. J Pharm Pharmacol 2005;57:63-168.
17. Philip AK, Dabas S, Pathak K. Optimized prodrug approach: a means for achieving enhanced anti-inflammatory potential in experimentally induced colitis. J Drug Target 2009 Apr;17(3):235-241.
18. REDDY MS, SINHA RV, REDDY DS; 1999. Colon targeted systems. Drugs Today; 35(7):537.
19. THREVEEN C, VINAY V., KRISHNA V.A; 2011, Colon specific drug delivery systems: a review on primary and novel approaches, IJPSRR, article-031
20. Watts P, Illum L. Colonic drug delivery. Drug Dev Ind Pharm 1997;23:893- 913 .
21. Wood E, Wilson CG, Hardy JG. The spreading of foam and solution enemas. Int J Pharm 1985;25:191-197 .
22. WU, C., MCGINITY, J.W., 1999. Non-traditional plasticization of polymeric films. Int. J.Pharm. 177, 15–27.
23. YASUDA, H., LAMAZE, C.E., 1971. Perms electivity of solutes in homogeneous water swollen polymer membranes. J. Macromol. Sci. Phys. B5 11, 111–134.
2. A. Martin, 1993; Buffered and Isotonic Solutions, Physical Pharmacy, Lippincott Williams and Wilkins, Baltimore,. pp. 169–189.
3. Akala EO, Elekwachi O, Chase V, Johnson H, Lazarre M, Scott K. Organic redox-initiated polymerization process for the fabrication of hydrogels for colon-specific drug delivery. Drug Dev Ind Pharm 2003 Apr;29(4):375-386.
4. Armand, J.Y., magnard, F., Bozon, J., Rollet, J., Taverdet, J.L., Vergnaud, J.M., 1987. Modelling of drug release in gastric liquid from galenic forms with Eudragit matrix. Int. J. Pharm. 40, 33–41.
5. Ashford, M., Fell, J.T., Attwood, D., Sharma, H.,Woodhead, P.J., 1993. An in vivo investigation into the suitability of pH dependent polymers for colonic targeting. Int.J. Pharm. 95, 193–199.
6. Basit A, Bloor J. Prespectives on colonic drug delivery, Business briefing. Pharmtech 2003; 185-190.
7. Brahamankar BM, Jaiswal SB; 1995.Biopharmaceutics and pharmacokinetics to controlled release medication of oral site specific / colon DDS, 457.
8. Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Pharm Sci 2003 Jan-Apr;6(1):33-66.
9. Chien YW. Oral drug delivery and delivery systems. In: Chien YW, editor. Novel drug delivery systems. New York: Marcel Dekker Inc; 1992; 139-196.
10. Dew M.J.; Hughes P.J.; Lee M.G.; Evans B.K. and Rhodes J; 1982.An Oral preparation to release drug in human colon. BR. .14:405-408.
11. FARA, J.W. 1989.Colonic drug absorption and metabolism, In: Novel Drug Delivery and its Therapeutic Applications, Eds, Prescott, L.F. and Nimmo, W.S. Wiley, Chichester, 103.
12. FLORY, P.J. (ED.), 1953. Principles of Polymer Chemistry. Cornell University, Ithaca, New York.
13. JOHN G. HARDY, Scintigraphic techniques in studying colon drug absorption, In: Peter R.Bieck, Editor“ Colonic drug absorption and metabolism” Marcel dekker Inc; vol-60 :70-104.
14. KARANJIT KAUR, KWONHO KIM; 2009 Studies of chitosan/organic acid/Eudragit® RS/RL-coated system for colonic delivery International Journal of Pharmaceutics 366, 140–148.
15. OKOR, R.S., 1982. Effect of polymer cation content on certain film properties. J. Pharm. Pharmacol. 34, 83–86.
16. Oluwatoyin AO, John TF. In vitro evaluation of khaya and albizia gums as compression coating for drug targeting to the colon. J Pharm Pharmacol 2005;57:63-168.
17. Philip AK, Dabas S, Pathak K. Optimized prodrug approach: a means for achieving enhanced anti-inflammatory potential in experimentally induced colitis. J Drug Target 2009 Apr;17(3):235-241.
18. REDDY MS, SINHA RV, REDDY DS; 1999. Colon targeted systems. Drugs Today; 35(7):537.
19. THREVEEN C, VINAY V., KRISHNA V.A; 2011, Colon specific drug delivery systems: a review on primary and novel approaches, IJPSRR, article-031
20. Watts P, Illum L. Colonic drug delivery. Drug Dev Ind Pharm 1997;23:893- 913 .
21. Wood E, Wilson CG, Hardy JG. The spreading of foam and solution enemas. Int J Pharm 1985;25:191-197 .
22. WU, C., MCGINITY, J.W., 1999. Non-traditional plasticization of polymeric films. Int. J.Pharm. 177, 15–27.
23. YASUDA, H., LAMAZE, C.E., 1971. Perms electivity of solutes in homogeneous water swollen polymer membranes. J. Macromol. Sci. Phys. B5 11, 111–134.