Formulation and Evaluation of Orally Disintegrating Taste masked Gemifloxacin Mesylate Tablet
Corresponding Author(s) : Dr. Sangeeta Asija
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 4 (2020): 2020 Volume - 8 Issue-4
Abstract
Gemifloxacin is a broad spectrum antibacterial agent active against gram positive and gram negative organism. It is very bitter in taste. In the present work an attempt has been made to develop orally disintegrating taste masked tablet of Gemifloxacin using ion exchangeresins (Amberlite IRP 88) as a taste masking agent. Different drug: resin ratios were tried to prepare taste maskedcomplex. FT-IR spectroscopy and differential scanning calorimetry were used to investigate the physical characteristics of the complex. Tablets were prepared by direct compression technique using two super disintegrants viz.cross povidone and sodium starch glycolate. Tablets of all batches were tested for various evaluation parameters. Tablets formulated with10% Crosspovidone (GRT05) showed lowest wetting time (16 sec). The % cumulative release of drug from tablet (GRT05) was found to be more than 99% within 40mins. It was thus possible to formulate Orally disintegrating tablets of Gemifloxacin using simple and cost effective, Ion Exchange Resin Complexation technique.
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References
2. Peter H. Jones, Elizabeth K. Rowley, Arlene L. Weiss, Dorothy L. Bishop, Alexander H. C. Chun, Insoluble Erythromycin salts, Journal of Pharmaceutical Sciences, 58 (3), 2009, 337–339.
3. Drlica K, Zhao X; DNA gyrase, topoisomerase IV, and the 4-quinolones. MicrobiolMolBiol Rev. (1997), 61 (3): 377-392.
4. AnuranjitaKundu and SriparnaDatta; Formulation and characterization of alginate microbeads of Norfloxacin by ionotropic gelation technique. International journal of advances in pharmacy, biology and chemistry. (2012), 1(3): 266-270.
5. Joseph P. Reo, Evaluation of a taste sensor instrument (electronic tongue) for use in formulation development, International Journal of Pharmaceutics. (2009), 65 – 72.
6. AditiTripathi, Taste Masking: A Novel Approach for Bitter and Obnoxious Drugs, Journal of Pharmaceutical Science and Bioscience Research: Volume 1, Issue 3: (2011), 136-142.
7. K.P. Sampath Kumar, Taste Masked Suspension, (2012),1- 6.
8. Alam MD, Nayyar P, Kumar SP. Novel technology for formulation and evaluation of mouth dissolving tablet - A review. AdvBiol Res 2018; 8(5):180-6.
9. Pooja A, Arora SV. Orodispersible tablets: A comprehensive review. Int J Res Dev Pharm Life Sci 2017; 2(2):270-84.
10. Sona. P. S., Muthulingam C., Formulation and evaluation of taste masked orally disintegrating tablets of Diclofenac sodium, International Journal of PharmTech Research, 3(2), 2011, 819- 826.
11. Rakesh Kumar Rishi. Orally Disintegrating Tablets – Novel Approach to Drug Delivery. The Pharma Review 2004; 2(12) : 34-36.
12. Devarajan, Padma V, Gore SP. Melt in Mouth Tablets – Innovative Oral Drug Delivery Systems. Express Pharma Pulse 2000; 7(1) : 16-18.
13. Kumar Ravi, Patil Swati, Patil M. B., PatilSachin R, Paschapur Mahesh S., Formulation evaluation of mouth dissolving tablets of Fenofibrate using sublimation technique, International Journal of ChemTech Research, 1(4), 2009, 840-850.