Gastro-Retentive Drug Delivery System of Rosiglitazone Maleate
Corresponding Author(s) : Dr. Sangeeta Asija
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 4 (2020): 2020 Volume - 8 Issue-4
Abstract
Gastro retentive tablets of Rosiglitazone Maleatewere developed to prolong the gastric residence time, leading to an increase in drug bioavailability and reduced dose frequency. Rosiglitazone Maleateis an anti-diabetic agent is used in the management of Type-II diabetes mellitus.The formulated Gastro retentivetablets containing8 mg Rosiglitazone Maleatewere developed using Hydroxyl propyl methyl cellulose (Benecil) and different additives.Theformulated tablets obtained by the direct compression method, followed by optimization of the evaluated parameters wereemployed to get the final optimized formulation. The resulting formulations indicated optimum hardness, uniform thickness,consistent weight uniformity and low friability. The formulated tablets were able to continuously float over the stimulatedgastric fluid for 24hrs.The results of in vitro drug release studies showed that optimized formulation (PF5) could release the drug (98%) for more than 24 hrs and remain buoyant for more than 24 hrs.
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References
2. Gupta, N.V. and Shivakumar, H.G., Preparation and characterization of superporous hydrogels as gastroretentive drug delivery system for rosiglitazone maleate. DARU Journal of Pharmaceutical Sciences, 2019.18(3).
3. Doro?y?ski, P., Kulinowski, P., Mendyk, A. and Jachowicz, R. Gastroretentive drug delivery systems with l-dopa based on carrageenans and hydroxypropylmethylcellulose. International Journal of Pharmaceutics, 2019, 404(1).
4. Jain, V. and Singh, R., Design and characterization of colon-specific drug delivery system containing paracetamol microsponges. Archives of Pharmaceutical Research, 2018, 34(5).
5. Gambhire, M.N., Ambade, K.W., Kurmi, S.D., Kadam, V.J. and Jadhav, K.R., Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride. AAPS PharmSciTech, 2017.8(3).
6. Basak, S.C., Rao, K.N., Manavalan, R. and Rao, P.R., Development and in vitro evaluation of an oral floating matrix tablet formulation of ciprofloxacin. Indian Journal of Pharmaceutical Sciences, 2017. 66(3).
7. Asnaashari, S., Khoei, N.S., Zarrintan, M.H., Adibkia, K. and Javadzadeh, Y., Preparation and evaluation of novel metronidazole sustained release and floating matrix tablets. Pharmaceutical Development and Technology, 2015. 16(4).
8. Anamika Saxena, Kaplesh Gaur, Virender Singh, Rajneesh Kanth singh and Ashok Dashora. Floating microspheres as drug delivery system. AJPPS, 2014; 1, 2, 27-36.
9. Sunil Kumar, M Das, K S Gupta, R Kumar, A Chongdar, L K Ghosh. Design, development, optimization and evaluation of Gastroretentive floating tablets of Atenolol. Der Pharmacia letter., 2013; 5, 3, 436-456.
10. Chabria Neetu B, N Narayana, Hygeia. Formulation & in vitro evaluation of oral floating Nicardipine HCl tablets. J.D.Med., 2013; 5, 2, 63-75.
11. Prasad K lende, M S Junajete, Arundhati D Deshmukh. Formulation optimization & in vitro evaluation of floating tablets of Stavudine. Am. J. Pharmatech Res., 2012; 2, 5, 723-739.