A review on massive rise in multiple spike protein mutation of a corona virus SARS-Cov-2 - 501.V2 variant reported in UK
Corresponding Author(s) : N.Sriram
srirampharma@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 4 (2020): 2020 Volume - 8 Issue-4
Abstract
A community of similar RNA viruses that cause diseases in mammals and birds are coronaviruses. They trigger respiratory tract infections in humans and birds that can range from moderate to lethal. SARS-CoV-2 Extreme Acute Respiratory Syndrome Coronavirus 2 was detected in China's e Wuhan province during September 2019. The total number of known positive cases has been estimated as of now (December 23, 2020) to be 78.2 million in all affected countries around the world and the death toll is 1,72 million. There are 10.2M positive cases in India and 146k people have died. The explanation behind the dramatic rise in Covid-19 cases in South and East England was discovered to be the latest SARS-CoV-2 strain at the end of December 2020. It is referred to as VUI (Variant Under Investigation) 202012/01, or the lineage B.1.1.7 is now originally recognised as Variant of Interest 202012/01 (VOC-202012/01). The purpose of his present work is to study the SARS-CoV-2 variant VOC-202012/01, VUI 202012/01 & 501.V2.
Keywords
SARS-CoV-2
Variant
VOC
VUI
1.
S. Kameshwaran, N.Sriram, V.Srividhya. A review on massive rise in multiple spike protein mutation of a corona virus SARS-Cov-2 - 501.V2 variant reported in UK . Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2020 Dec. 26 [cited 2025 Jul. 13];8(4):745-8. Available from: https://ijamscr.com/ijamscr/article/view/945
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
References
-
1. Prem C, Pragati P, Upendra R, e al. Epidemic and Challenges of Coronavirus Disease-2019 (COVID-19): India Response; 2020.
2. Lupia T, Scabini S, Pinna SM, et al. 2019-novel coronavirus outbreak: A new challenge. J Glob Antimicrob Resist. 2020;21:22–27.
3. Sohrabi C, Alsafi Z, O’Neill N, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020 Apr;76:71–76.
4. https://www.worldometers.info/coronavirus/Retrieved 23 December 2020
5. Information shared by Public Health England and Public Health Wales at a joint ECDC/WHO teleconference on 16 December 2020.
6. Statens Serum Institute. Ny covid-virusstamme i England [23 December, 2020]. Available from: https://www.ssi.dk/aktuelt/nyheder/2020/ny-covid-virusstamme-i-england.
7. Government of the Netherlands. Restrictions on travel from the United Kingdom [23 December, 2020]. Available from: https://www.government.nl/latest/news/2020/12/20/restrictions-on-travel-from-the-unitedkingdom.
8. The Brussels Times. Netherlands bans flights from UK over new Covid mutation [23 December, 2020]. Available from: https://www.brusselstimes.com/news/belgium-all-news/146288/netherlands-bans-flightsfrom-uk-over-new-covid-mutation-found-coronavirus-van-ranst-who/.
9. Chand, Meera; Hopkins, Susan; Dabrera, Gavin; Achison, Christina; Barclay, Wendy; Ferguson, Neil; Volz, Erik; Loman, Nick; Rambaut, Andrew; Barrett, Jeff (23 December 2020). Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01 (PDF)(Report). Public Health England. Retrieved 22 December 2020.
10. PHE investigating a novel strain of COVID-19". Public Health England. 23 December 2020.
11. Rambaut, Andrew; Loman, Nick; Pybus, Oliver; Barclay, Wendy; Barrett, Jeff; Carabelli, Alesandro; Connor, Tom; Peacock, Tom; L. Robertson, David; Vol, Erik (2020). Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations (Report). Written on behalf of COVID-19 Genomics Consortium UK. Retrieved 20 December 2020.
12. Kupferschmidt, Kai (20 December 2020). "Mutant coronavirus in the United Kingdom sets off alarms but its importance remains unclear". Science Mag. Retrieved 21 December2020.
13. Zimmer, Carel; Carey, Benedict (21 December 2020). "The U.K. Coronavirus Variant: What We Know = A newly identified variant of the SARS-CoV-2 virus appears to be more contagious than established ones. Here's what scientists know". The New York Times. Retrieved 23 December 2020.
14. "Covid: Ireland, Italy, Belgium and Netherlands ban flights from UK". BBC News. 20 December 2020.
15. Peacock, Sharon (22 December 2020). "Here's what we know about the new variant of coronavirus". The Guardian.
16. "New coronavirus variant: What do we know?". BBC. Retrieved 22 December 2020..
17. Chand et al. (2020), p. 5.
18. "South Africa announces a new coronavirus variant". The New York Times. 18 December 2020. Retrieved 20 December 2020.
19. Abdool Karim, Salim S. (19 December 2020). "The 2nd Covid-19 wave in South Africa:Transmissibility & a 501.V2 variant". 11th slide. SCRIBD.
20. "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Archived from the original on 9 October 2008. Retrieved 5 March 2018.
21. Nextstrain [Internet]. 2020. Available from: https://nextstrain.org/
22. Higgins-Dunn, N. (19 December 2020). "The U.K. has identified a new Covid-19 strain that spreads more quickly. Here's what they know". MSNBC.
23. Gallagher, James (20 December 2020). "New coronavirus variant: What do we know?". BBC News. Retrieved 21 December 2020.
24. Ross, T.; Spence, E. (19 December 2020). "London Begins Emergency Lockdown as U.K. Fights New Virus Strain". Bloomberg News.
25. Henley, Jon; Jones, Sam; Giuffrida, Angela; Holmes, Oliver (20 December 2020). "EU to hold crisis talks as countries block travel from UK over new Covid strain". The Guardian.
26. Alan Hope (20 December 2020). "Netherlands bans flights from UK over new Covid mutation". The Brussels Times.
27. "Coronavirus, in Italia un soggetto positivo alla variante inglese" [Coronavirus, one person tests positive in Italy for the English variant]. la Repubblica (in Italian). 20 December 2020.
28. Knudsen, T.H. (20 December 2020). "Dansk Oxford-professor: Danmark skal gøre alt for, at ny virusvariant ikke spreder sig" (in Danish).
29. Mandavilli, Apoorva; Landler, Mark; Castle, Stephen (20 December 2020). "Scientists urge calm about coronavirus mutations, which are not unexpected". New York Times.
30. https://indianexpress.com/article/explained/simply-put-decoding-the-virus-variant-7114202/ Retrieved 23 December 2020.
References
1. Prem C, Pragati P, Upendra R, e al. Epidemic and Challenges of Coronavirus Disease-2019 (COVID-19): India Response; 2020.
2. Lupia T, Scabini S, Pinna SM, et al. 2019-novel coronavirus outbreak: A new challenge. J Glob Antimicrob Resist. 2020;21:22–27.
3. Sohrabi C, Alsafi Z, O’Neill N, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020 Apr;76:71–76.
4. https://www.worldometers.info/coronavirus/Retrieved 23 December 2020
5. Information shared by Public Health England and Public Health Wales at a joint ECDC/WHO teleconference on 16 December 2020.
6. Statens Serum Institute. Ny covid-virusstamme i England [23 December, 2020]. Available from: https://www.ssi.dk/aktuelt/nyheder/2020/ny-covid-virusstamme-i-england.
7. Government of the Netherlands. Restrictions on travel from the United Kingdom [23 December, 2020]. Available from: https://www.government.nl/latest/news/2020/12/20/restrictions-on-travel-from-the-unitedkingdom.
8. The Brussels Times. Netherlands bans flights from UK over new Covid mutation [23 December, 2020]. Available from: https://www.brusselstimes.com/news/belgium-all-news/146288/netherlands-bans-flightsfrom-uk-over-new-covid-mutation-found-coronavirus-van-ranst-who/.
9. Chand, Meera; Hopkins, Susan; Dabrera, Gavin; Achison, Christina; Barclay, Wendy; Ferguson, Neil; Volz, Erik; Loman, Nick; Rambaut, Andrew; Barrett, Jeff (23 December 2020). Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01 (PDF)(Report). Public Health England. Retrieved 22 December 2020.
10. PHE investigating a novel strain of COVID-19". Public Health England. 23 December 2020.
11. Rambaut, Andrew; Loman, Nick; Pybus, Oliver; Barclay, Wendy; Barrett, Jeff; Carabelli, Alesandro; Connor, Tom; Peacock, Tom; L. Robertson, David; Vol, Erik (2020). Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations (Report). Written on behalf of COVID-19 Genomics Consortium UK. Retrieved 20 December 2020.
12. Kupferschmidt, Kai (20 December 2020). "Mutant coronavirus in the United Kingdom sets off alarms but its importance remains unclear". Science Mag. Retrieved 21 December2020.
13. Zimmer, Carel; Carey, Benedict (21 December 2020). "The U.K. Coronavirus Variant: What We Know = A newly identified variant of the SARS-CoV-2 virus appears to be more contagious than established ones. Here's what scientists know". The New York Times. Retrieved 23 December 2020.
14. "Covid: Ireland, Italy, Belgium and Netherlands ban flights from UK". BBC News. 20 December 2020.
15. Peacock, Sharon (22 December 2020). "Here's what we know about the new variant of coronavirus". The Guardian.
16. "New coronavirus variant: What do we know?". BBC. Retrieved 22 December 2020..
17. Chand et al. (2020), p. 5.
18. "South Africa announces a new coronavirus variant". The New York Times. 18 December 2020. Retrieved 20 December 2020.
19. Abdool Karim, Salim S. (19 December 2020). "The 2nd Covid-19 wave in South Africa:Transmissibility & a 501.V2 variant". 11th slide. SCRIBD.
20. "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Archived from the original on 9 October 2008. Retrieved 5 March 2018.
21. Nextstrain [Internet]. 2020. Available from: https://nextstrain.org/
22. Higgins-Dunn, N. (19 December 2020). "The U.K. has identified a new Covid-19 strain that spreads more quickly. Here's what they know". MSNBC.
23. Gallagher, James (20 December 2020). "New coronavirus variant: What do we know?". BBC News. Retrieved 21 December 2020.
24. Ross, T.; Spence, E. (19 December 2020). "London Begins Emergency Lockdown as U.K. Fights New Virus Strain". Bloomberg News.
25. Henley, Jon; Jones, Sam; Giuffrida, Angela; Holmes, Oliver (20 December 2020). "EU to hold crisis talks as countries block travel from UK over new Covid strain". The Guardian.
26. Alan Hope (20 December 2020). "Netherlands bans flights from UK over new Covid mutation". The Brussels Times.
27. "Coronavirus, in Italia un soggetto positivo alla variante inglese" [Coronavirus, one person tests positive in Italy for the English variant]. la Repubblica (in Italian). 20 December 2020.
28. Knudsen, T.H. (20 December 2020). "Dansk Oxford-professor: Danmark skal gøre alt for, at ny virusvariant ikke spreder sig" (in Danish).
29. Mandavilli, Apoorva; Landler, Mark; Castle, Stephen (20 December 2020). "Scientists urge calm about coronavirus mutations, which are not unexpected". New York Times.
30. https://indianexpress.com/article/explained/simply-put-decoding-the-virus-variant-7114202/ Retrieved 23 December 2020.
2. Lupia T, Scabini S, Pinna SM, et al. 2019-novel coronavirus outbreak: A new challenge. J Glob Antimicrob Resist. 2020;21:22–27.
3. Sohrabi C, Alsafi Z, O’Neill N, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020 Apr;76:71–76.
4. https://www.worldometers.info/coronavirus/Retrieved 23 December 2020
5. Information shared by Public Health England and Public Health Wales at a joint ECDC/WHO teleconference on 16 December 2020.
6. Statens Serum Institute. Ny covid-virusstamme i England [23 December, 2020]. Available from: https://www.ssi.dk/aktuelt/nyheder/2020/ny-covid-virusstamme-i-england.
7. Government of the Netherlands. Restrictions on travel from the United Kingdom [23 December, 2020]. Available from: https://www.government.nl/latest/news/2020/12/20/restrictions-on-travel-from-the-unitedkingdom.
8. The Brussels Times. Netherlands bans flights from UK over new Covid mutation [23 December, 2020]. Available from: https://www.brusselstimes.com/news/belgium-all-news/146288/netherlands-bans-flightsfrom-uk-over-new-covid-mutation-found-coronavirus-van-ranst-who/.
9. Chand, Meera; Hopkins, Susan; Dabrera, Gavin; Achison, Christina; Barclay, Wendy; Ferguson, Neil; Volz, Erik; Loman, Nick; Rambaut, Andrew; Barrett, Jeff (23 December 2020). Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01 (PDF)(Report). Public Health England. Retrieved 22 December 2020.
10. PHE investigating a novel strain of COVID-19". Public Health England. 23 December 2020.
11. Rambaut, Andrew; Loman, Nick; Pybus, Oliver; Barclay, Wendy; Barrett, Jeff; Carabelli, Alesandro; Connor, Tom; Peacock, Tom; L. Robertson, David; Vol, Erik (2020). Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations (Report). Written on behalf of COVID-19 Genomics Consortium UK. Retrieved 20 December 2020.
12. Kupferschmidt, Kai (20 December 2020). "Mutant coronavirus in the United Kingdom sets off alarms but its importance remains unclear". Science Mag. Retrieved 21 December2020.
13. Zimmer, Carel; Carey, Benedict (21 December 2020). "The U.K. Coronavirus Variant: What We Know = A newly identified variant of the SARS-CoV-2 virus appears to be more contagious than established ones. Here's what scientists know". The New York Times. Retrieved 23 December 2020.
14. "Covid: Ireland, Italy, Belgium and Netherlands ban flights from UK". BBC News. 20 December 2020.
15. Peacock, Sharon (22 December 2020). "Here's what we know about the new variant of coronavirus". The Guardian.
16. "New coronavirus variant: What do we know?". BBC. Retrieved 22 December 2020..
17. Chand et al. (2020), p. 5.
18. "South Africa announces a new coronavirus variant". The New York Times. 18 December 2020. Retrieved 20 December 2020.
19. Abdool Karim, Salim S. (19 December 2020). "The 2nd Covid-19 wave in South Africa:Transmissibility & a 501.V2 variant". 11th slide. SCRIBD.
20. "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Archived from the original on 9 October 2008. Retrieved 5 March 2018.
21. Nextstrain [Internet]. 2020. Available from: https://nextstrain.org/
22. Higgins-Dunn, N. (19 December 2020). "The U.K. has identified a new Covid-19 strain that spreads more quickly. Here's what they know". MSNBC.
23. Gallagher, James (20 December 2020). "New coronavirus variant: What do we know?". BBC News. Retrieved 21 December 2020.
24. Ross, T.; Spence, E. (19 December 2020). "London Begins Emergency Lockdown as U.K. Fights New Virus Strain". Bloomberg News.
25. Henley, Jon; Jones, Sam; Giuffrida, Angela; Holmes, Oliver (20 December 2020). "EU to hold crisis talks as countries block travel from UK over new Covid strain". The Guardian.
26. Alan Hope (20 December 2020). "Netherlands bans flights from UK over new Covid mutation". The Brussels Times.
27. "Coronavirus, in Italia un soggetto positivo alla variante inglese" [Coronavirus, one person tests positive in Italy for the English variant]. la Repubblica (in Italian). 20 December 2020.
28. Knudsen, T.H. (20 December 2020). "Dansk Oxford-professor: Danmark skal gøre alt for, at ny virusvariant ikke spreder sig" (in Danish).
29. Mandavilli, Apoorva; Landler, Mark; Castle, Stephen (20 December 2020). "Scientists urge calm about coronavirus mutations, which are not unexpected". New York Times.
30. https://indianexpress.com/article/explained/simply-put-decoding-the-virus-variant-7114202/ Retrieved 23 December 2020.