Antihyperlipidemic activity of flower extract of Tecoma stans against dexamethasone-induced hyperlipidemia in rats
Corresponding Author(s) : Dr.N.Sriram
srirampharma@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 3 (2020): 2020 Volume - 8 Issue-3
Abstract
Introduction
Natural products derived from plants kingdom play a vital part in preventing or treating various diseases or disorders in humans. Hyperlipidemia is one of the major pathological factors of cardiovascular diseases and diabetes mellitus. On the other hand, Tecoma stans belonging to the family ?Bignoniaceae, was found to possess many pharmacological activities such as anti-inflammatory, antibacterial, and anti cancer activities along with CNS depressant activities.
Materials and Methods
The present study is an attempt to investigate its antihyperlipidemic activity by in vivo animal model. Hyperlipidemia model can be induced by administered with dexamethasone in rats with significant increase in serum cholesterol and triglyceride (TG) levels along with increase in the atherogenic index.
Results
The ethanolic extract of flowers of T.stans (200 and 400 mg/kg) treatment has shown significant inhibition against dexamethasone-induced hyperlipidemia in rats by maintaining the serum levels of cholesterol, TGs and near to the normal levels.
Keywords
Tecoma Stans
Dexamethasone
Hyperlipidemia
Cholesterol and Triglyceride
1.
Dr.N.Sriram, Dr. Rajaneeekar Dasari, Kameshwaran.S, Asok Kumar DS, Abhenaya.K. Antihyperlipidemic activity of flower extract of Tecoma stans against dexamethasone-induced hyperlipidemia in rats. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2020 Sep. 23 [cited 2025 Jul. 13];8(3):622-8. Available from: https://ijamscr.com/ijamscr/article/view/905
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References
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1. Dubey NK, Kumar R, Tirupathi P. Global promotion of herbal medicine: India opportunity. Curr Sci 86, 2004, 37-41.
2. Namdeo A. Plant cell elicitation for production of secondary metabolites: A review. Pharmacogn Rev 1, 2007, 69-79.
3. Wilson EC. Screening plants for new medicines. Biodiversity. Washington, DC: National Academy Press; 1988, 51.
4. Ghsatak A, Asthana OP. Recent trends in hyperlipoproteinemias and its pharmacotherapy. Indian J Pharmacol; 27, 1995, 14-29.
5. Moss JN, Dajani E. Anti-hyperlipidemic agents. In: Turner RA, Hebborn P, editors. Screening Methods of Toxicology. Vol. 2. New York: Academic Press; 1971, 121.
6. Anonymous. Drug Index. New Delhi: Pass Publication Pvt. Ltd.; 1971, 482.
7. Kameshwaran S, Suresh V, Arunachalam G, Kanthlal SK, Mohanraj M In vitro and in vivo anticancer activity of methanolic flower extract of Tecoma stans flower. Int Res J Pharm 3(3), 2012, 246–252
8. S.Kameshwaran, V.Suresh, M.Mohanraj, Anti cancer potential of Tecoma stans flower extracts. Pharma tutor, ART- 1275, 2012.
9. Kameshwaran S, Suresh V, Arunachalam G, Frank P R, Manikandan V. Evaluation of antinociceptive and antiinflammatory potential of flower extract Tecoma stans. Indian J Pharmacol 44, 2012, 543-4
10. Kameshwaran Sugavanam; Suresh Velayutham; Arunachalam Ganesan . CNS depressent activity of different extracts of Tecoma stans flowers [J]. , 7(1), 2012, 39-43.
11. S. Kameshwaran, C. Jothimanivannan, R. Senthilkumar and A.R. Kothai. Anti-obesity and Hypolipidemic Activity of Methanol Extract of Tecoma stans Flowers on Atherogenic Diet Induced Obesity in Rats. Pharmacologia, 4, 2013, 77-81.
12. Kameshwaran, S., A.R. Kothai, C. Jothimanivannan and R. Senthil Kumar. Evaluation of hepatoprotective activity of Tecoma stans flowers. Pharmacologia, 4, 2013, 236-242.
13. S. Kameshwaran, C. Jothimanivannan, R. Senthilkumar, S. Thenmozhi, R. Sundaraganapathy and M. Dhanalakshmi. Acute Toxicity Study and Faecal Dropping Capability of Ethanolic Extract of Tecoma stans in Albino Rats. Pharmacologia, 4, 2013, 464-468.
14. Kameshwaran S, Thenmozhi S, Vasuki K, Dhanalakshmi M, Dhanapal C. Antiurolithiatic activity of aqueous and methanolic extracts of Tecoma stans flowers in rats. International Journal of Pharmaceutical & Biological Archives 4(3), 2013, 446 – 450
15. Kameshwaran Sugavanam, Raju Senthilkumar and Thenmozhi Shanmugam. Ameliorative Effect of Tecoma stans Extract on Diabetic Cardiomyopathy against Streptozotocin-Induced Diabetes in Wistar Rats. Journal of Pharmacy and Pharmacology 1, 2013, 55-62.
16. Kameshwaran S, Sundaraganapathy R, Thenmozhi S, Dhanalakshmi M, Vasuki K, Manjuladevi K. Tecoma Stans Protect Central Nervous System Against Oxidative Damages of Electromagnetic Radiation On Rat. Acta Biomedica Scientia. 1(1), 2014, 40-44.
17. S.Kameshwaran, R.Sundaraganapathy, S.Thenmozhi, M.Dhanalakshmi, K.Vasuki, C.Dhanapal. Assessment of antidepressant activity of methanol and aqueous extract of Tecoma stans flowers using tail suspension test and forced swim test. International Journal of Pharmacology Research. 4(2), 2014, 78-82.
18. S.Kameshwaran, R.Sundaraganapathy, S.Thenmozhi, M.Dhanalakshmi, K.Vasuki, K.Manjuladevi, C.Dhanapal “Sodium and Water excretory Potential of Flower Extract of Tecoma stans” International Journal of Innovative Drug Discovery, 4(2), 2014, 62-64.
19. S. Kameshwaran, R. Senthilkumar, S. Thenmozhi and M. Dhanalakshmi, Wound Healing Potential of Ethanolic Extract of Tecoma stans Flowers in Rats. Pharmacologia, 5, 2014, 215-221.
20. R.Sundara Ganapathy, S.Mohan, S.Kameshwaran, C.Dhanapal, Estimation of polyphenols and flavonoids contents and exploration of antimicrobial nature of Tecoma stans extracts. International Journal of Phytopharmacy Research, 6(3), 2015, 129-134
References
1. Dubey NK, Kumar R, Tirupathi P. Global promotion of herbal medicine: India opportunity. Curr Sci 86, 2004, 37-41.
2. Namdeo A. Plant cell elicitation for production of secondary metabolites: A review. Pharmacogn Rev 1, 2007, 69-79.
3. Wilson EC. Screening plants for new medicines. Biodiversity. Washington, DC: National Academy Press; 1988, 51.
4. Ghsatak A, Asthana OP. Recent trends in hyperlipoproteinemias and its pharmacotherapy. Indian J Pharmacol; 27, 1995, 14-29.
5. Moss JN, Dajani E. Anti-hyperlipidemic agents. In: Turner RA, Hebborn P, editors. Screening Methods of Toxicology. Vol. 2. New York: Academic Press; 1971, 121.
6. Anonymous. Drug Index. New Delhi: Pass Publication Pvt. Ltd.; 1971, 482.
7. Kameshwaran S, Suresh V, Arunachalam G, Kanthlal SK, Mohanraj M In vitro and in vivo anticancer activity of methanolic flower extract of Tecoma stans flower. Int Res J Pharm 3(3), 2012, 246–252
8. S.Kameshwaran, V.Suresh, M.Mohanraj, Anti cancer potential of Tecoma stans flower extracts. Pharma tutor, ART- 1275, 2012.
9. Kameshwaran S, Suresh V, Arunachalam G, Frank P R, Manikandan V. Evaluation of antinociceptive and antiinflammatory potential of flower extract Tecoma stans. Indian J Pharmacol 44, 2012, 543-4
10. Kameshwaran Sugavanam; Suresh Velayutham; Arunachalam Ganesan . CNS depressent activity of different extracts of Tecoma stans flowers [J]. , 7(1), 2012, 39-43.
11. S. Kameshwaran, C. Jothimanivannan, R. Senthilkumar and A.R. Kothai. Anti-obesity and Hypolipidemic Activity of Methanol Extract of Tecoma stans Flowers on Atherogenic Diet Induced Obesity in Rats. Pharmacologia, 4, 2013, 77-81.
12. Kameshwaran, S., A.R. Kothai, C. Jothimanivannan and R. Senthil Kumar. Evaluation of hepatoprotective activity of Tecoma stans flowers. Pharmacologia, 4, 2013, 236-242.
13. S. Kameshwaran, C. Jothimanivannan, R. Senthilkumar, S. Thenmozhi, R. Sundaraganapathy and M. Dhanalakshmi. Acute Toxicity Study and Faecal Dropping Capability of Ethanolic Extract of Tecoma stans in Albino Rats. Pharmacologia, 4, 2013, 464-468.
14. Kameshwaran S, Thenmozhi S, Vasuki K, Dhanalakshmi M, Dhanapal C. Antiurolithiatic activity of aqueous and methanolic extracts of Tecoma stans flowers in rats. International Journal of Pharmaceutical & Biological Archives 4(3), 2013, 446 – 450
15. Kameshwaran Sugavanam, Raju Senthilkumar and Thenmozhi Shanmugam. Ameliorative Effect of Tecoma stans Extract on Diabetic Cardiomyopathy against Streptozotocin-Induced Diabetes in Wistar Rats. Journal of Pharmacy and Pharmacology 1, 2013, 55-62.
16. Kameshwaran S, Sundaraganapathy R, Thenmozhi S, Dhanalakshmi M, Vasuki K, Manjuladevi K. Tecoma Stans Protect Central Nervous System Against Oxidative Damages of Electromagnetic Radiation On Rat. Acta Biomedica Scientia. 1(1), 2014, 40-44.
17. S.Kameshwaran, R.Sundaraganapathy, S.Thenmozhi, M.Dhanalakshmi, K.Vasuki, C.Dhanapal. Assessment of antidepressant activity of methanol and aqueous extract of Tecoma stans flowers using tail suspension test and forced swim test. International Journal of Pharmacology Research. 4(2), 2014, 78-82.
18. S.Kameshwaran, R.Sundaraganapathy, S.Thenmozhi, M.Dhanalakshmi, K.Vasuki, K.Manjuladevi, C.Dhanapal “Sodium and Water excretory Potential of Flower Extract of Tecoma stans” International Journal of Innovative Drug Discovery, 4(2), 2014, 62-64.
19. S. Kameshwaran, R. Senthilkumar, S. Thenmozhi and M. Dhanalakshmi, Wound Healing Potential of Ethanolic Extract of Tecoma stans Flowers in Rats. Pharmacologia, 5, 2014, 215-221.
20. R.Sundara Ganapathy, S.Mohan, S.Kameshwaran, C.Dhanapal, Estimation of polyphenols and flavonoids contents and exploration of antimicrobial nature of Tecoma stans extracts. International Journal of Phytopharmacy Research, 6(3), 2015, 129-134
2. Namdeo A. Plant cell elicitation for production of secondary metabolites: A review. Pharmacogn Rev 1, 2007, 69-79.
3. Wilson EC. Screening plants for new medicines. Biodiversity. Washington, DC: National Academy Press; 1988, 51.
4. Ghsatak A, Asthana OP. Recent trends in hyperlipoproteinemias and its pharmacotherapy. Indian J Pharmacol; 27, 1995, 14-29.
5. Moss JN, Dajani E. Anti-hyperlipidemic agents. In: Turner RA, Hebborn P, editors. Screening Methods of Toxicology. Vol. 2. New York: Academic Press; 1971, 121.
6. Anonymous. Drug Index. New Delhi: Pass Publication Pvt. Ltd.; 1971, 482.
7. Kameshwaran S, Suresh V, Arunachalam G, Kanthlal SK, Mohanraj M In vitro and in vivo anticancer activity of methanolic flower extract of Tecoma stans flower. Int Res J Pharm 3(3), 2012, 246–252
8. S.Kameshwaran, V.Suresh, M.Mohanraj, Anti cancer potential of Tecoma stans flower extracts. Pharma tutor, ART- 1275, 2012.
9. Kameshwaran S, Suresh V, Arunachalam G, Frank P R, Manikandan V. Evaluation of antinociceptive and antiinflammatory potential of flower extract Tecoma stans. Indian J Pharmacol 44, 2012, 543-4
10. Kameshwaran Sugavanam; Suresh Velayutham; Arunachalam Ganesan . CNS depressent activity of different extracts of Tecoma stans flowers [J]. , 7(1), 2012, 39-43.
11. S. Kameshwaran, C. Jothimanivannan, R. Senthilkumar and A.R. Kothai. Anti-obesity and Hypolipidemic Activity of Methanol Extract of Tecoma stans Flowers on Atherogenic Diet Induced Obesity in Rats. Pharmacologia, 4, 2013, 77-81.
12. Kameshwaran, S., A.R. Kothai, C. Jothimanivannan and R. Senthil Kumar. Evaluation of hepatoprotective activity of Tecoma stans flowers. Pharmacologia, 4, 2013, 236-242.
13. S. Kameshwaran, C. Jothimanivannan, R. Senthilkumar, S. Thenmozhi, R. Sundaraganapathy and M. Dhanalakshmi. Acute Toxicity Study and Faecal Dropping Capability of Ethanolic Extract of Tecoma stans in Albino Rats. Pharmacologia, 4, 2013, 464-468.
14. Kameshwaran S, Thenmozhi S, Vasuki K, Dhanalakshmi M, Dhanapal C. Antiurolithiatic activity of aqueous and methanolic extracts of Tecoma stans flowers in rats. International Journal of Pharmaceutical & Biological Archives 4(3), 2013, 446 – 450
15. Kameshwaran Sugavanam, Raju Senthilkumar and Thenmozhi Shanmugam. Ameliorative Effect of Tecoma stans Extract on Diabetic Cardiomyopathy against Streptozotocin-Induced Diabetes in Wistar Rats. Journal of Pharmacy and Pharmacology 1, 2013, 55-62.
16. Kameshwaran S, Sundaraganapathy R, Thenmozhi S, Dhanalakshmi M, Vasuki K, Manjuladevi K. Tecoma Stans Protect Central Nervous System Against Oxidative Damages of Electromagnetic Radiation On Rat. Acta Biomedica Scientia. 1(1), 2014, 40-44.
17. S.Kameshwaran, R.Sundaraganapathy, S.Thenmozhi, M.Dhanalakshmi, K.Vasuki, C.Dhanapal. Assessment of antidepressant activity of methanol and aqueous extract of Tecoma stans flowers using tail suspension test and forced swim test. International Journal of Pharmacology Research. 4(2), 2014, 78-82.
18. S.Kameshwaran, R.Sundaraganapathy, S.Thenmozhi, M.Dhanalakshmi, K.Vasuki, K.Manjuladevi, C.Dhanapal “Sodium and Water excretory Potential of Flower Extract of Tecoma stans” International Journal of Innovative Drug Discovery, 4(2), 2014, 62-64.
19. S. Kameshwaran, R. Senthilkumar, S. Thenmozhi and M. Dhanalakshmi, Wound Healing Potential of Ethanolic Extract of Tecoma stans Flowers in Rats. Pharmacologia, 5, 2014, 215-221.
20. R.Sundara Ganapathy, S.Mohan, S.Kameshwaran, C.Dhanapal, Estimation of polyphenols and flavonoids contents and exploration of antimicrobial nature of Tecoma stans extracts. International Journal of Phytopharmacy Research, 6(3), 2015, 129-134