Taste masked dry syrup: A review
Corresponding Author(s) : Bhavana Choudhary
ijamscr@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 2 (2020): 2020 Volume 8- Issue -2
Abstract
Oral route of drug administration has been one of the most convenient and accepted route of drug delivery and amongst it the intraoral route is the most preferred due to its convenience and rapid onset of action. Intraoral dosage forms have evolved as an alternative to conventional tablets, capsules and liquid preparations. There is an important category of suspension that is available as dry powders intended for suspension in liquid vehicles. These are dry mixtures containing the drug and suitable suspending and dispersing agents to be diluted and agitated with a specific quantity of vehicle, most often purified water. Drugs that are instable if maintained for extended periods in the presence of aqueous vehicle (eg., many antibiotic drugs) are frequently supplied as dry powder mixtures for reconstitution at the time of dispensing. This type of preparation is designated in the USP by a title “for Oral Suspension”. The reconstituted system is the formulation of choice when the drug stability is a major concern. After reconstitution, these systems have a short but acceptable life if stored at refrigerator temperatures. Re-constitutable oral systems show the adequate chemical stability of the drug during shelf life, avoids the physical stability problems related to solubility, pH and incompatibilities with other ingredients and also reduce the weight of the final product because the aqueous vehicle is absent and consequently the transportation expenses may be reduced.
Keywords
Taste masking
Dry syrup
Taste buds
Liquid oral Suspension
1.
Bhavana Choudhary. Taste masked dry syrup: A review. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2020 Aug. 15 [cited 2025 Jul. 11];8(2):381-6. Available from: https://ijamscr.com/ijamscr/article/view/876
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References
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[1]. Vijay D. Wagh, Taste Masking Methods and Techniques in Oral Pharmaceuticals: Current Perspectives, Journal of Pharmacy Research 2(6), 2009, 1049-1054.
[2]. K Gowthamarajan, Pop the Pills without Bitterness Taste-Masking Technologies for Bitter Drugs General Article, Resonance 2004, 25-32.
[3]. Reddy LH, Ghosh BR. Fast dissolving drug delivery systems: A review of the literature. Ind J Pharm Sci, 64(4), 2002, 331-336
[4]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 3(6), 2001, 58- 61.
[5]. James Swarbrick & James C. Boylan ”Flavors and Flavor modifiers” Encyclopedia of Pharmaceutical Technology (4), 101-132
[6]. Fu Y, Yan S, Jeong SH, Kimura S, Park K Orally fast disintegrating tablets: developments, technologies, taste masking and clinical studies. Crit Rev Ther Drug Carrier Syst 21, 2004, 433-76.
[7]. Rao, M.Y.., Bader, F. Masking the taste of chloroquine by preparing multiple emulsions. The Eastern Pharmacists. 1991, 123 -124.
[8]. Sharma S. New generation of tablet: fast dissolving tablet. http://www.pharmainfo.net. Accessed 15, 2008.
[9]. Jonathan Vaassen et. Al,Taste masked lipid pellets with enhanced release of hydrophobic active ingredient, International Journal of Pharmaceutics, 429, 2012, 1–2, 99–103.
[10]. Glazko et al., Antibiot. Chemother. 2(234), 1952, and Jumao-as et al. Chloramphenicol esters and method for obtaining same, US Patent 2662906, 1953.
[11]. Hamilton EL, Luts EM. Advanced Orally disintegrating tablets bring significant benefits to patients and product life cycle. Drug Deliv Technol, 5(1), 2005, 34-37.
[12]. Gargely, G.; Gargely,T.; Gargely,I. Pharmaceutical Preparation in the Form of an Effervescent and/or Disintegrating Tablet or an Instant Granule and Process of Producing It. PCT Int. Appl. WO9313760, 22, 1993.
[13]. Brahmankar D M. and Jaiswal S B. Biopharmaceutics and pharmacokinetics, Vallabh Prakashan, New Delhi 1, 1995, 162-163.
[14]. Sanjay Daharwal, Taste masking method for bitter drug and tasteless dispersible tablet: an overview, 1-7.
[15]. Habib W, Khankari R, Honts J. Fast dissolving drug delivery systems. Crt Rev Ther Drug Carrier Syst, 17(1), 2000, 61-72.
[16]. Gupta A.K., Practical Approaches for Taste Masking of Bitter Drug: A Review,
[17]. Lieberman HA, Rieger MM, Banker GS. Pharmaceutical dosage forms and disperse system. (New York: Marcel dekkar Inc.); 2(2), 1994, 149-77.
[18]. H. Sohi, Y. Sultana, and R. Khar. Taste masking technologies in oral pharmaceuticals: Recent developments and approaches. Drug Dev. Ind. Pharm. 30, 2004, 429–448.
[19]. Mizumoto T, Masuda Y, Takeshi Y, Estuo Y, Katsuhide T. Formulation design of a novel fast- disintegrating tablet. Int J Pharm, 306(1-2), 2005, 83–90.
[20]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 3(6), 2001, 58- 61.
[21]. Hanawa T, Watanabe A, Tsuchiya T, Ikoma R, Hidaka M, Sugihara M. New Oral dosage form for elderly patients: Preparation and characterization of silk fibroin gel. Chem Pharm Bull, 43(2), 1995, 284-288.
[22]. Shalini sharma and shaila lewis, Taste masking technologies: A Review, International journal of pharmacy and pharmaceutical sciences 2(2), 2010.
[23]. Casilda Bardeskar, Racheal Geeverghese. Reconstituitable oral suspensions (Dry Syrups): an overview. World J Pharm Res 4, 2015, 462-84.
[24]. Umut Can Oz, Burcu Devrim, Asuman Bozk?r, Kandemir Canefe. Development of reconstitutable suspensions containing diclofenac sodium-loaded microspheres for pediatric delivery. J Microencapsulation 32, 2015, 317-28.
[25]. European Medicines Agency ICH Topic Q 6 A Specifications: test procedures and acceptance criteria for new drug substances and new drug products: Chemical Substances; 2000.
References
[1]. Vijay D. Wagh, Taste Masking Methods and Techniques in Oral Pharmaceuticals: Current Perspectives, Journal of Pharmacy Research 2(6), 2009, 1049-1054.
[2]. K Gowthamarajan, Pop the Pills without Bitterness Taste-Masking Technologies for Bitter Drugs General Article, Resonance 2004, 25-32.
[3]. Reddy LH, Ghosh BR. Fast dissolving drug delivery systems: A review of the literature. Ind J Pharm Sci, 64(4), 2002, 331-336
[4]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 3(6), 2001, 58- 61.
[5]. James Swarbrick & James C. Boylan ”Flavors and Flavor modifiers” Encyclopedia of Pharmaceutical Technology (4), 101-132
[6]. Fu Y, Yan S, Jeong SH, Kimura S, Park K Orally fast disintegrating tablets: developments, technologies, taste masking and clinical studies. Crit Rev Ther Drug Carrier Syst 21, 2004, 433-76.
[7]. Rao, M.Y.., Bader, F. Masking the taste of chloroquine by preparing multiple emulsions. The Eastern Pharmacists. 1991, 123 -124.
[8]. Sharma S. New generation of tablet: fast dissolving tablet. http://www.pharmainfo.net. Accessed 15, 2008.
[9]. Jonathan Vaassen et. Al,Taste masked lipid pellets with enhanced release of hydrophobic active ingredient, International Journal of Pharmaceutics, 429, 2012, 1–2, 99–103.
[10]. Glazko et al., Antibiot. Chemother. 2(234), 1952, and Jumao-as et al. Chloramphenicol esters and method for obtaining same, US Patent 2662906, 1953.
[11]. Hamilton EL, Luts EM. Advanced Orally disintegrating tablets bring significant benefits to patients and product life cycle. Drug Deliv Technol, 5(1), 2005, 34-37.
[12]. Gargely, G.; Gargely,T.; Gargely,I. Pharmaceutical Preparation in the Form of an Effervescent and/or Disintegrating Tablet or an Instant Granule and Process of Producing It. PCT Int. Appl. WO9313760, 22, 1993.
[13]. Brahmankar D M. and Jaiswal S B. Biopharmaceutics and pharmacokinetics, Vallabh Prakashan, New Delhi 1, 1995, 162-163.
[14]. Sanjay Daharwal, Taste masking method for bitter drug and tasteless dispersible tablet: an overview, 1-7.
[15]. Habib W, Khankari R, Honts J. Fast dissolving drug delivery systems. Crt Rev Ther Drug Carrier Syst, 17(1), 2000, 61-72.
[16]. Gupta A.K., Practical Approaches for Taste Masking of Bitter Drug: A Review,
[17]. Lieberman HA, Rieger MM, Banker GS. Pharmaceutical dosage forms and disperse system. (New York: Marcel dekkar Inc.); 2(2), 1994, 149-77.
[18]. H. Sohi, Y. Sultana, and R. Khar. Taste masking technologies in oral pharmaceuticals: Recent developments and approaches. Drug Dev. Ind. Pharm. 30, 2004, 429–448.
[19]. Mizumoto T, Masuda Y, Takeshi Y, Estuo Y, Katsuhide T. Formulation design of a novel fast- disintegrating tablet. Int J Pharm, 306(1-2), 2005, 83–90.
[20]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 3(6), 2001, 58- 61.
[21]. Hanawa T, Watanabe A, Tsuchiya T, Ikoma R, Hidaka M, Sugihara M. New Oral dosage form for elderly patients: Preparation and characterization of silk fibroin gel. Chem Pharm Bull, 43(2), 1995, 284-288.
[22]. Shalini sharma and shaila lewis, Taste masking technologies: A Review, International journal of pharmacy and pharmaceutical sciences 2(2), 2010.
[23]. Casilda Bardeskar, Racheal Geeverghese. Reconstituitable oral suspensions (Dry Syrups): an overview. World J Pharm Res 4, 2015, 462-84.
[24]. Umut Can Oz, Burcu Devrim, Asuman Bozk?r, Kandemir Canefe. Development of reconstitutable suspensions containing diclofenac sodium-loaded microspheres for pediatric delivery. J Microencapsulation 32, 2015, 317-28.
[25]. European Medicines Agency ICH Topic Q 6 A Specifications: test procedures and acceptance criteria for new drug substances and new drug products: Chemical Substances; 2000.
[2]. K Gowthamarajan, Pop the Pills without Bitterness Taste-Masking Technologies for Bitter Drugs General Article, Resonance 2004, 25-32.
[3]. Reddy LH, Ghosh BR. Fast dissolving drug delivery systems: A review of the literature. Ind J Pharm Sci, 64(4), 2002, 331-336
[4]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 3(6), 2001, 58- 61.
[5]. James Swarbrick & James C. Boylan ”Flavors and Flavor modifiers” Encyclopedia of Pharmaceutical Technology (4), 101-132
[6]. Fu Y, Yan S, Jeong SH, Kimura S, Park K Orally fast disintegrating tablets: developments, technologies, taste masking and clinical studies. Crit Rev Ther Drug Carrier Syst 21, 2004, 433-76.
[7]. Rao, M.Y.., Bader, F. Masking the taste of chloroquine by preparing multiple emulsions. The Eastern Pharmacists. 1991, 123 -124.
[8]. Sharma S. New generation of tablet: fast dissolving tablet. http://www.pharmainfo.net. Accessed 15, 2008.
[9]. Jonathan Vaassen et. Al,Taste masked lipid pellets with enhanced release of hydrophobic active ingredient, International Journal of Pharmaceutics, 429, 2012, 1–2, 99–103.
[10]. Glazko et al., Antibiot. Chemother. 2(234), 1952, and Jumao-as et al. Chloramphenicol esters and method for obtaining same, US Patent 2662906, 1953.
[11]. Hamilton EL, Luts EM. Advanced Orally disintegrating tablets bring significant benefits to patients and product life cycle. Drug Deliv Technol, 5(1), 2005, 34-37.
[12]. Gargely, G.; Gargely,T.; Gargely,I. Pharmaceutical Preparation in the Form of an Effervescent and/or Disintegrating Tablet or an Instant Granule and Process of Producing It. PCT Int. Appl. WO9313760, 22, 1993.
[13]. Brahmankar D M. and Jaiswal S B. Biopharmaceutics and pharmacokinetics, Vallabh Prakashan, New Delhi 1, 1995, 162-163.
[14]. Sanjay Daharwal, Taste masking method for bitter drug and tasteless dispersible tablet: an overview, 1-7.
[15]. Habib W, Khankari R, Honts J. Fast dissolving drug delivery systems. Crt Rev Ther Drug Carrier Syst, 17(1), 2000, 61-72.
[16]. Gupta A.K., Practical Approaches for Taste Masking of Bitter Drug: A Review,
[17]. Lieberman HA, Rieger MM, Banker GS. Pharmaceutical dosage forms and disperse system. (New York: Marcel dekkar Inc.); 2(2), 1994, 149-77.
[18]. H. Sohi, Y. Sultana, and R. Khar. Taste masking technologies in oral pharmaceuticals: Recent developments and approaches. Drug Dev. Ind. Pharm. 30, 2004, 429–448.
[19]. Mizumoto T, Masuda Y, Takeshi Y, Estuo Y, Katsuhide T. Formulation design of a novel fast- disintegrating tablet. Int J Pharm, 306(1-2), 2005, 83–90.
[20]. Brown D. Orally disintegrating tablets: Taste over speed. Drug Deliv Tech, 3(6), 2001, 58- 61.
[21]. Hanawa T, Watanabe A, Tsuchiya T, Ikoma R, Hidaka M, Sugihara M. New Oral dosage form for elderly patients: Preparation and characterization of silk fibroin gel. Chem Pharm Bull, 43(2), 1995, 284-288.
[22]. Shalini sharma and shaila lewis, Taste masking technologies: A Review, International journal of pharmacy and pharmaceutical sciences 2(2), 2010.
[23]. Casilda Bardeskar, Racheal Geeverghese. Reconstituitable oral suspensions (Dry Syrups): an overview. World J Pharm Res 4, 2015, 462-84.
[24]. Umut Can Oz, Burcu Devrim, Asuman Bozk?r, Kandemir Canefe. Development of reconstitutable suspensions containing diclofenac sodium-loaded microspheres for pediatric delivery. J Microencapsulation 32, 2015, 317-28.
[25]. European Medicines Agency ICH Topic Q 6 A Specifications: test procedures and acceptance criteria for new drug substances and new drug products: Chemical Substances; 2000.