The Effect of Magnetization Transfer Contrast on Muscle Image and Tissue Contrast in Foot MRI: a Qualitative Study
Corresponding Author(s) : Kadek Yuda Astina
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 8 No. 2 (2020): 2020 Volume 8- Issue -2
Abstract
Background
Magnetization Transfer Contrast (MTC) is a technique with different methods that can provide such a good contrast for tissue characterization. MTC is based on very clear biophysical and biochemical properties, because different tissues have different macromolecular compositions, the degree of interaction can be very different which can produce very high tissue contrast. Muscle becomes the second tissue with the largest percentage after skin (60-80%) experiencing signal attenuation when the MTC is applied. At Premier Bintaro Hospital reported that related MRI images have not produced good tissue contrast, therefore a combination technique that can be used in the sequences is urgently needed.
Methods
A qualitative study with experimental approach was done to confirm the availability and probability of applying the MTC technique to related sequences as well as qualitatively assessing the effect of using MTC on the generated muscle image signal. One patient with pedis MRI examination used as sample to assessing the effect of MTC in form of on-resonance MTC and off-resonance MTC.
Results
Qualitatively MTC has an impact on signal reduction in muscle image by 13-15% using both on-resonance and off resonance methods. Respondents also gave an assessment by increasing subjective contrast (visually on contrast, detail, and sharpness) on the use of both MTC methods. The muscle signal is suppressed due to the composition of macromolecules in muscle tissue including the bound pool category. Increased tissue contrast occurs both objectively and subjectively due to a decrease in muscle image signals without a decrease in the signal image of the surrounding tissue.
Conclusion
There is a change in the intensity of the muscle image signal and an increase in tissue contrast both objectively and subjectively on the pedis MRI with application of Magnetization Contrast Techniques (MTC).
Keywords
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R. W. de Boer, “Magnetization transfer contrast Part 2 : Clinical applications,” Medica Mundi (Philips Heal., 2, 74–83.
[2]. M. Rottmar et al., “Magnetization Transfer MR Imaging to Monitor Muscle Tissue Formation during Myogenic in Vivo Differentiation of Muscle Precursor Cells,” RSNA, 281(2016), 436–443.
[3]. X. P. Zhu, S. Zhao, and I. Isherwood, “Magnetization transfer contrast (MTC) imaging of skeletal muscle at 0.26 Tesla - Changes in signal intensity following exercise,” Br. J. Radiol., 65(769), 1992, 39–43,.
[4]. R. Kijowski and Garry E. Gold, “Routine 3D Magnetic Resonance Imaging of Joints,” J. Magn. Reson. Imaging, 33(1), 2011, 1–4, 758–771.
[5]. M. D. Torsten B. Moeller and M. D. Emil Reif, I Moeller, MRI Parameters and Positioning © 2003 Thieme All rights reserved. Usage subject to terms and conditions of license. 2003.
[6]. M. M. Ribeiro, L. Rumor, M. Oliveira, J. G. O’Neill, and J. C. Maurício, “STIR, SPIR and SPAIR techniques in magnetic resonance of the breast: A comparative study,” J. Biomed. Sci. Eng., 6(3), 2013, 395–402.
Kadek Y A et al / Int. J. of Allied Med. Sci. and Clin. Research Vol-8(2) 2020 [231-236]
236
[7]. M. J. Lizak, M. B. Datiles, A. H. Aletras, P. F. Kador, and R. S. Balaban, “MRI of the human eye using magnetization transfer contrast enhancement,” Investig. Ophthalmol. Vis. Sci., 41(12), 2000, 3878–3881.
[8]. G. H. Welsch et al., “Magnetization transfer contrast and T2 mapping in the evaluation of cartilage repair tissue with 3T MRI,” J. Magn. Reson. Imaging, 28(4), 2008, 979–986.
[9]. S. Ropele et al., “A comparison of magnetization transfer ratio, magnetization transfer rate, and the native relaxation time of water protons related to relapsing-remitting multiple sclerosis,” Am. J. Neuroradiol., 21(10), 2000, 1885–1891.
[10]. A. Manuscript, “Muscle Damage and Regeneration,” 40(4), 2015, 779–788.
[11]. J. M. Seo, Y. C. Yoon, and J. W. Kwon, “3D isotropic turbo spin-echo intermediate-weighted sequence with refocusing control in knee imaging: Comparison study with 3D isotropic fast-field echo sequence,” Acta radiol., 52(10), 2011, 1119–1124
References
[2]. M. Rottmar et al., “Magnetization Transfer MR Imaging to Monitor Muscle Tissue Formation during Myogenic in Vivo Differentiation of Muscle Precursor Cells,” RSNA, 281(2016), 436–443.
[3]. X. P. Zhu, S. Zhao, and I. Isherwood, “Magnetization transfer contrast (MTC) imaging of skeletal muscle at 0.26 Tesla - Changes in signal intensity following exercise,” Br. J. Radiol., 65(769), 1992, 39–43,.
[4]. R. Kijowski and Garry E. Gold, “Routine 3D Magnetic Resonance Imaging of Joints,” J. Magn. Reson. Imaging, 33(1), 2011, 1–4, 758–771.
[5]. M. D. Torsten B. Moeller and M. D. Emil Reif, I Moeller, MRI Parameters and Positioning © 2003 Thieme All rights reserved. Usage subject to terms and conditions of license. 2003.
[6]. M. M. Ribeiro, L. Rumor, M. Oliveira, J. G. O’Neill, and J. C. Maurício, “STIR, SPIR and SPAIR techniques in magnetic resonance of the breast: A comparative study,” J. Biomed. Sci. Eng., 6(3), 2013, 395–402.
Kadek Y A et al / Int. J. of Allied Med. Sci. and Clin. Research Vol-8(2) 2020 [231-236]
236
[7]. M. J. Lizak, M. B. Datiles, A. H. Aletras, P. F. Kador, and R. S. Balaban, “MRI of the human eye using magnetization transfer contrast enhancement,” Investig. Ophthalmol. Vis. Sci., 41(12), 2000, 3878–3881.
[8]. G. H. Welsch et al., “Magnetization transfer contrast and T2 mapping in the evaluation of cartilage repair tissue with 3T MRI,” J. Magn. Reson. Imaging, 28(4), 2008, 979–986.
[9]. S. Ropele et al., “A comparison of magnetization transfer ratio, magnetization transfer rate, and the native relaxation time of water protons related to relapsing-remitting multiple sclerosis,” Am. J. Neuroradiol., 21(10), 2000, 1885–1891.
[10]. A. Manuscript, “Muscle Damage and Regeneration,” 40(4), 2015, 779–788.
[11]. J. M. Seo, Y. C. Yoon, and J. W. Kwon, “3D isotropic turbo spin-echo intermediate-weighted sequence with refocusing control in knee imaging: Comparison study with 3D isotropic fast-field echo sequence,” Acta radiol., 52(10), 2011, 1119–1124