Potential Ointment of Carica Papaya Leaf Extract Against Postpartum Perineal Wounds Healing First: Experimental Study in Galuh Wistar Mice (Rattus Norvegicus)

Abstract

Background

Perineal rupture occurs in about 85% of vaginal deliveries. If the wound is not treated properly, it causes pain and infection which prevents wound healing. Perineal wound care in addition to using 10% povidone iodine, the use of papaya carica leaf herbs is more effective in accelerating healing with active compounds of flavonoids, saponins, and tannins which have the potential to be anti-inflammatory and antiseptic so as to stimulate collagen which plays a role in wound healing.

Objective

Prove the potential of Carica leaf extract ointment for the healing of the first postpartum Galuh Wistar (rattus norvegicus) wound perineum.

Methods

True Execution, simple random sampling, pre post control group design. The subjects of the study were galuh wistar rats after giving birth for the first time as many as 25, divided into 5 groups. The wound healing variable is measured by the REEDA scale. Evaluation is carried out every day for 7 days. Test the hypothesis using Wilcoxon, Krussall Wallis, Mann Whitney U Test.

Results

Ointment 10% papaya carica leaf extract (EDPC) has the potential to accelerate the healing of perineal wounds by achieving a score of 0, which means good wound healing, and achieve a minimum score (p = 0.025) on the fifth day compared to 5% EDPC ointment, 15% EDPC ointment, Betadine ointment and ointment base.

Conclusions and Recommendations

EDPC 10% ointment effectively speeds up wound healing before 7 days. It is expected that observation of perineal wounds is further enhanced by microscopic examination. Further researchers can conduct further research on the active ingredient of other Carica papaya leaf extracts that have the potential to inhibit gram-positive and gram-negative bacteria in perineal wounds.