An Audit of Primary Central Nervous System Tumor Patient’s in a Tertiary Care Hospital of North India

Abstract

Background
Central nervous system tumors are heterogeneous group of neoplasm having difference in prevalence according to age groups and sex. There are very few epidemiological studies about Primary central nervous system from northern India.
Aim
To study epidemiological patterns of Primary Central nervous system tumors.
Material and Methods
Retrospective Study conducted in a tertiary care Centre of North India from January 2011 to December 2016. Data regarding age, sex, histology, symptoms, imaging, location, surgery, radiotherapy, chemotherapy, recurrence if any and salvage treatment for recurrence were collected and analyzed.
Results
We analyzed 214 cases. Age ranged from 4years to 72 years. Males (71.9%) outnumbered females (28.03%). M: F ratio was 3.85:1.5. Neuroepithelial tumors were the most common histological finding (84%). Glioblastoma multiforme was the most common subset (33.1%), followed by anaplastic astrocytoma (13%) and diffuse infiltrating astrocytoma (13%) in neuroepithelial tumors. Medulloblastoma (6.5%) was found to be commonest tumor in pediatric age group. The most common symptom was headache (51.4%) followed by Seizures (25.2%). CECT Brain was done in 89.71%, while MRI brain was done in 10.28% patients. Frontal lobe was the most common site of involvement. Surgical procedure consisted of excision in 37.3% followed by decompression in 24.7%.
Conclusion
Our study helps to provide information regarding burden of disease in our area. Major limitation of our study it is institution based and may not reflect entire population. It also reflects the need to strengthen follow-up practices