Anti oxidant and hepatic enzyme changes in kanakalinga karpoorati mezhugu, treated experimental hypothyroid disorder

Abstract

Many metal and mineral raw drugs are prepared in Siddha medicine as Mezhugu, Pathangam, Parpam, Chenduram, Kalangu, Kattu, Urukku and Chunnams and need global standards. A detailed in-vivo and in-vitro studies of KLK mezhugu for its quality, efficacy other indications should be ascertained using modern parameters. Chemical nature of the KLK mezhugu depends upon the purification methods, materials mixed, quantity, quality of heat and flame, type of fuel, duration of heat, periodicity of grinding, size of the particle and solubility, assimilation and absorption in the alimentary tract are some of important factors to be studied. Male albino rats were used for this present thyro-toxicity study. Animals were provided with normal rats feed and normal water ad libitum. Methimazole was given to induce hypothyroidism and KLK mezhugu in water suspension was used a test drug. Animals were fasted overnight, anaesthetized with ether and sacrificed by cervical decapitation, blood was drawn and the serum was separated for biochemical analysis. Thyroid protective activity was done by assessing the significant changes in body weight, Serum T3 triiodothyronine, T4 thyroxine, TSH, Albumin, Cholesterol, Triglycerides, Lipid peroxide, Transaminases, Acid phosphotases were estimated and the Mean values standard were calculated for all the values carried out. The result of this study shows the significant protect activity in thyroid necrosis against methimazole induced thyroid-toxicity.