Formulation and invitro evaluation of bucco adhesive bi layer tablets of Eprosartan

Abstract

Eprosartan buccoadhesive bilayered tablets containing bioadhesive layer and drug free backing layer were formulated to release the drug for extended periods of time with reduction in dosing frequency. The tablets were prepared by direct compression method using bioadhesive polymers like Carbopol 934p, Magnesium stearate and Hydroxy propyl cellulose alone or in combination, Ethyl cellulose has incorporated as an impermeable backing layer. Tablets were evaluated for weight and content uniformity, thickness, hardness, surface pH, swelling index, invitro drug release and invitro drug permeation. The modified invitro assembly was used to determine and compare the bioadhesive strength of tablets all characteristics of formulated tablets were shown to be dependent on composition of bioadhesive materials used. Maximum bioadhesion strength was observed for tablets formulated with Carbopol 934P.