Antiepileptic effect of ethanolic extract of seeds of Peganum harmala on maximal electroshock seizure model in albino mice.

Abstract

Aim of the study

The present study was under taken to evaluate the antiepileptic effect ethanolic extract of seeds of Peganum harmala (PHEE) in mice to validate its pharmacological property.

Materials and methods

Ethanolic extract of seeds of Peganum harmala was screened for antiepileptic effect by using maximal electroshock seizure threshold test at a dose of 50 mg/kg and 100 mg/kg. Distilled water and diazepam were employed as control and standard groups respectively.

Results

Ethanolic extract of seeds of Peganum harmala at the dose of 50 mg/kg and 100 mg/kg in combination with standard drug Diazepam at the dose of 3.0 mg/kg increases the threshold of maximal electroconvulsions in dose dependant manner 11.2±1.52 and 12.3±1.71 respectively.

Conclusion

Ethanolic extract of seeds of Peganum harmala was able to potentiate the effect of Diazepam in convulsions.