In-vitro anthelmintic activity of methanolic leaf extract of Abrus precatorius Linn. (fabaceae)
Corresponding Author(s) : S. Selvadurai
asdurai85@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 4 No. 3 (2016): 2016 Volume 4- Issue -3
Abstract
The present study was aimed to investigation of the anthelmintic potential of crude methanolic extract of the leaves of Abrus precatorius Linn. On Indian earth-worm “Pheretima posthum” and “Tubifex tubifex”. Three concentrations (5, 10, 15 mg/ml) of methanolic extract were studied in activity which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal) of the worms. Piperazine citrate (10 mg/ml) was used as reference standard drug whereas distilled water as control. Determination of paralysis time and death time of the worms were recorded. The result shows that methanolic extract possesses vermicidal activity and found to be effective as an anthelmintic. Therefore, the anthelmintic activity of the methanolic extract of Abrus precatorius Linn. Leaves have been reported.
Keywords
Abrus Precatorius Linn
Anthelmintic Activity
Piperazine Citrate
Methanolic Extract
Pheretima Posthum
Tubifex Tubifex.
1.
S. Selvadurai. In-vitro anthelmintic activity of methanolic leaf extract of Abrus precatorius Linn. (fabaceae). Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2020 Aug. 5 [cited 2025 Oct. 26];4(3):344-8. Available from: https://ijamscr.com/ijamscr/article/view/278
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References
-
Ajaiyeoba EO, Onocha PA and Olarenwaju OT In vitro anthelmintic properties of Buchholzia coriaceae
and Gynandropsis gynandra extract. Pharm Bio 39, 2001, 217? 220
[2]. Chandan HS, Tapas AR, Sakarkar DM Anthelmintic activity of extracts of Coriandrum sativum Linn. in
Indian earthworm. Int. J Phytomedicine 3, 2011, 36-40.
[3]. Chatterjee KD Patasitology, Protozoology and Helminthology. Calcutta: Guha Ray Sree Saraswaty Pres
Ltd.; 1967, 168-169.
[4]. Dr. Ravindra Fernando; National Poisons Information Centre, Written a review about Abrus precatorius,
Faculty of Medicine, Kynsey Road, Colombo 8,Sri Lanka.
[5]. Hossain E, Chandra G, Nandy AP, Mandal SC & Gupta JK Anthelmintic effect of a methanol extract
of leaves of Dregea volubilis on Paramphistomum explanatum. Parasitol Res 110, 2012, 809–814.
[6]. Kosalge SB, Fursule RA Investigation of In vitro Anthelmintic activity of Thespesia Lampas (Cav.). Asian
J Pharm Clin Res 2(2), 2009, 69-71.
Phytoconstituents
Petroleum ether
extract
Chloroform
extract
Acetone
extract
Methanolic
extract
Aqueous
extract
Alkaloids (+) (+) (+) (+) (-)
Carbohydrates (-) (+) (+) (+) (+)
Glycosides (-) (-) (-) (+) (+)
Flavonoids (-) (-) (-) (+) (+)
Phytosterols (-) (-) (-) (-) (-)
Fixed oils and Fats (-) (-) (-) (-) (-)
Saponins (-) (-) (-) (-) (+)
Phenolic compounds and
Tannins
(+) (-) (+) (+) (+)
Lignins (-) (-) (-) (-) (-)
Proteins and Free Amino
acids
(-) (-) (-) (-) (+)
Gums and Mucilage (-) (-) (-) (-) (-)
Selvadurai S et al / Int. J. of Allied Med. Sci. and Clin. Research Vol-4(3) 2016 [344-348]
348
[7]. Kokate CK, Purohit AP, Gokhale SB Text Book of Pharmacognosy. 41st ed. Pune: Nirali Prakashani;
K.R.Karitikaran; B.D. Basu , Indian medicinal plants, I, 2008, 711
[8]. Kumar T, Alexander A, Dewangan D, Nagori K. Anthelmintic Activity of the Whole Plant of Bauhinia
purpurea (linn.). Asian J Pharm Clin Res 4(3), 2011, 110-111
[9]. Tripathi KD. Essentials of Medical Pharmacology. 6th Ed. New Delhi: Jaypee Brothers Medical Publishers
(P) Ltd. 2008, 808-810.
References
Ajaiyeoba EO, Onocha PA and Olarenwaju OT In vitro anthelmintic properties of Buchholzia coriaceae
and Gynandropsis gynandra extract. Pharm Bio 39, 2001, 217? 220
[2]. Chandan HS, Tapas AR, Sakarkar DM Anthelmintic activity of extracts of Coriandrum sativum Linn. in
Indian earthworm. Int. J Phytomedicine 3, 2011, 36-40.
[3]. Chatterjee KD Patasitology, Protozoology and Helminthology. Calcutta: Guha Ray Sree Saraswaty Pres
Ltd.; 1967, 168-169.
[4]. Dr. Ravindra Fernando; National Poisons Information Centre, Written a review about Abrus precatorius,
Faculty of Medicine, Kynsey Road, Colombo 8,Sri Lanka.
[5]. Hossain E, Chandra G, Nandy AP, Mandal SC & Gupta JK Anthelmintic effect of a methanol extract
of leaves of Dregea volubilis on Paramphistomum explanatum. Parasitol Res 110, 2012, 809–814.
[6]. Kosalge SB, Fursule RA Investigation of In vitro Anthelmintic activity of Thespesia Lampas (Cav.). Asian
J Pharm Clin Res 2(2), 2009, 69-71.
Phytoconstituents
Petroleum ether
extract
Chloroform
extract
Acetone
extract
Methanolic
extract
Aqueous
extract
Alkaloids (+) (+) (+) (+) (-)
Carbohydrates (-) (+) (+) (+) (+)
Glycosides (-) (-) (-) (+) (+)
Flavonoids (-) (-) (-) (+) (+)
Phytosterols (-) (-) (-) (-) (-)
Fixed oils and Fats (-) (-) (-) (-) (-)
Saponins (-) (-) (-) (-) (+)
Phenolic compounds and
Tannins
(+) (-) (+) (+) (+)
Lignins (-) (-) (-) (-) (-)
Proteins and Free Amino
acids
(-) (-) (-) (-) (+)
Gums and Mucilage (-) (-) (-) (-) (-)
Selvadurai S et al / Int. J. of Allied Med. Sci. and Clin. Research Vol-4(3) 2016 [344-348]
348
[7]. Kokate CK, Purohit AP, Gokhale SB Text Book of Pharmacognosy. 41st ed. Pune: Nirali Prakashani;
K.R.Karitikaran; B.D. Basu , Indian medicinal plants, I, 2008, 711
[8]. Kumar T, Alexander A, Dewangan D, Nagori K. Anthelmintic Activity of the Whole Plant of Bauhinia
purpurea (linn.). Asian J Pharm Clin Res 4(3), 2011, 110-111
[9]. Tripathi KD. Essentials of Medical Pharmacology. 6th Ed. New Delhi: Jaypee Brothers Medical Publishers
(P) Ltd. 2008, 808-810.
and Gynandropsis gynandra extract. Pharm Bio 39, 2001, 217? 220
[2]. Chandan HS, Tapas AR, Sakarkar DM Anthelmintic activity of extracts of Coriandrum sativum Linn. in
Indian earthworm. Int. J Phytomedicine 3, 2011, 36-40.
[3]. Chatterjee KD Patasitology, Protozoology and Helminthology. Calcutta: Guha Ray Sree Saraswaty Pres
Ltd.; 1967, 168-169.
[4]. Dr. Ravindra Fernando; National Poisons Information Centre, Written a review about Abrus precatorius,
Faculty of Medicine, Kynsey Road, Colombo 8,Sri Lanka.
[5]. Hossain E, Chandra G, Nandy AP, Mandal SC & Gupta JK Anthelmintic effect of a methanol extract
of leaves of Dregea volubilis on Paramphistomum explanatum. Parasitol Res 110, 2012, 809–814.
[6]. Kosalge SB, Fursule RA Investigation of In vitro Anthelmintic activity of Thespesia Lampas (Cav.). Asian
J Pharm Clin Res 2(2), 2009, 69-71.
Phytoconstituents
Petroleum ether
extract
Chloroform
extract
Acetone
extract
Methanolic
extract
Aqueous
extract
Alkaloids (+) (+) (+) (+) (-)
Carbohydrates (-) (+) (+) (+) (+)
Glycosides (-) (-) (-) (+) (+)
Flavonoids (-) (-) (-) (+) (+)
Phytosterols (-) (-) (-) (-) (-)
Fixed oils and Fats (-) (-) (-) (-) (-)
Saponins (-) (-) (-) (-) (+)
Phenolic compounds and
Tannins
(+) (-) (+) (+) (+)
Lignins (-) (-) (-) (-) (-)
Proteins and Free Amino
acids
(-) (-) (-) (-) (+)
Gums and Mucilage (-) (-) (-) (-) (-)
Selvadurai S et al / Int. J. of Allied Med. Sci. and Clin. Research Vol-4(3) 2016 [344-348]
348
[7]. Kokate CK, Purohit AP, Gokhale SB Text Book of Pharmacognosy. 41st ed. Pune: Nirali Prakashani;
K.R.Karitikaran; B.D. Basu , Indian medicinal plants, I, 2008, 711
[8]. Kumar T, Alexander A, Dewangan D, Nagori K. Anthelmintic Activity of the Whole Plant of Bauhinia
purpurea (linn.). Asian J Pharm Clin Res 4(3), 2011, 110-111
[9]. Tripathi KD. Essentials of Medical Pharmacology. 6th Ed. New Delhi: Jaypee Brothers Medical Publishers
(P) Ltd. 2008, 808-810.