Pattern of glomerular diseases in tertiary care center. A retrospective observational study

Abstract

Background

There is limited population-based epidemiological data on renal disease. The knowledge of the epidemiology of biopsied renal diseases provides useful information in clinical practice.

Aim

To find out the prevalence of primary and secondary glomerular diseases and to study the pattern of the glomerular disease in a tertiary care center.

Material and Methods

This was a retrospective cross-sectional observational study where we saw the data of more than 20,000 patients in the department of Nephrology. In a study the clinical and histopathological data of these patients were analyzed. Age, gender, address, record number, date of assessment and date of last follow-up were noted.

Results

This study shows review of total 3120 renal biopsies retrospectively from 1973-2013, out of which 1822 (58.39%) were male and 1298 (41.60%) were female. The mean age of patients was 26.20 + 25.45 years (range 1 month to 94 years). The classification of histopathology of glomerular disease was done in primary and secondary glomerular disease. In Primary glomerulonephritis (PGD) Minimal Change Disease (MCD) was 21.25% the most common presentation followed by Membrano Proliferative glomerulonephritis (MPGN) 18.5% and Focal Segmental glomerular sclerosis (FSGS) 14.95%, while in Secondary glomerular disease (SGD) Lupus Nephritis (LN) 9.16% was commonest presentation followed by Amyloidosis 3.16% & Diabetic Nephropathy 0.33% (DN).

Conclusion

MPGN and FSGS were increasing and MCD was the leading histopathological pattern.