Antiulcer activity of ethanolic bark extract of dalbergia sissooon experimental ulcer models

Abstract

Gastric ulcer is one of the major health problem in the world. There is great demand of alternative herbal remedies for the treatment of ulcer as they have better cultural acceptability, minimal side effects, and better compatibility with the human body.D. Sissoo has been traditionally used for various ailments including gastric problem. Our study aimed to evaluate the antiulcer activity of crude ethanolic bark extract of Dalbergia sissoo(EBED) using pylorus ligation and Indomethacin induced ulcer model in Wistar albino rats.Antiulcer activity was evaluated by using four groups as; control (tween 80 1% v/v solution, 5 ml/kg), standard (Ranitidine 80 mg/kg), 250 mg/kg and 500 mg/kg of bark extract given orally (p.o.). Various parameters like mean ulcer index, percentage protection, volume of gastric juice, gastric P^H, protein, carbohydrate, pepsin, free and total acidity and ratio of total carbohydrates and proteins (TC:TP) were determined. Our study revealed the significant decrease (p<0.01) in mean ulcer index in EBED treated group in both the models compared to control. Furthermore, our study showed the significant decrease (p<0.01 and p<0.001) in the offensive factors like free and total acidity, pepsin content and protein content whereas significant increase in the defensive factors like total carbohydrate content(p<0.01) and TC:TP as compared to control in dose dependent manner. We concluded that EBEDpossess more potent antiulcer activity than leaf extract in our previous study in reducing the development of gastric ulcer as well as increasing the healing of the gastric ulcer in dose dependent manner.