Crocin (acetaminophen) induced toxic Epidermal necrosis: A rare case report

Abstract

Acetaminophen is a mostly preferable drug for the treatment of analgesic and antipyretic. The main mechanism of action, It acts on hypothalamus to produce antipyretic effect and act peripherally to block pain impulse generation, also inhibits prostaglandins synthesis in central nerve system. Toxic epidermal Necrosis (TEN) commonly termed as idiosyncratic reactions to drug. It is a serious and life threatening adverse drug reaction. Here, we report a case of TEN in a patient who developed the lesion after oral administration of CROCINE ACTIVE (ACETAMINOPHEN). These drugs have rarely been concerned in this disorder. The suspected drug in this case was ‘Crocin Active (500mg)’. The patient was managed with antibiotics, corticosteroids and parenteral fluids and topical safromycine. Almost all various drugs induced dermatological disorders toxic epidermal necrosis and Steven Johnson syndrome is a key role in terms of mortality. Promptly recognition of that condition, withhold the drug and immediately send to hospital then provide appropriate treatment its play a vital role for reducing mortality