A prospective epidemiological study of comorbid conditions in psoriasis

Abstract

Aim

• To determine the prevalence of diabetes, hypertension, obesity in psoriatic patients and controls.


• To determine the abnormal lipid parameters and serum uric acid levels in psoriatic patients and in controls


• To determine the prevalence of metabolic syndrome and cardiovascular disease in both psoriatic patients and control population.


• To determine the association of psoriasis with diabetes, hypertension, lipid abnormalities, obesity, cardiovascular disease and metabolic syndrome.

Materials

The study comprised 100 cases of psoriasis and 100 controls visiting the inpatient and outpatient Department of Dermatology at Rajah muthiah medical college & hospital. All clinically diagnosed cases of psoriasis of more than 18 yrs. Patients who are willing to undergo the laboratory investigations and those who give consent for the study. Patients taking systemic drugs for diabetes, hypertension & cardiovascular diseases for the past 3 months and those who are under control. Pregnant and lactating women

Methodology

A prospective clinical case control study, with 100 patients of psoriasis and 100 controls were undertaken to know the prevalence of diabetes and hypertension in cases and controls and the incidence of abnormal lipid parameters, metabolic syndrome and cardiovascular disease

Conclusion

Patients had increased prevalence of diabetes, hypertension, hypertriglyceridemia, metabolic syndrome when compared to controls. A correlation was found between the severity of the disease and diabetes mellitus, hypertension, hypertriglyceridemia and metabolic syndrome. However no correlation was found between psoriasis and serum uric acid levels, obesity and cardiovascular disease.