Anti obesity activity and beneficial effects of methanolic extract of Desmostachya bipinnata, Canthium dicoccum, Sebestiania chaemelea in HFD and Progesterone induced obesity in rats and mice

Abstract

Obesity is very serious and concerned problem these days.  From the first human civilization, research is going to find the drugs to treat obesity and its complications. Despite availability of many drugs in market to treat obesity, no single drug is ideal for treating all sorts of problems caused by obesity. So the research is going on finding perfect drug. Prior going to evaluating drugs on humans, it is necessary to go for preclinical evaluation and usually the rodents are suitable models. The ideal obesity models available for obesity are induced by using chemicals and high fat diet. Methanolic extract of aerial parts of Desmostachya bipinnata, Canthium dicoccum, Sebestiania chaemelea plant was studied for its Anti-obesity activity in animal experimental models. Wistar albino rats, albino mice were used to study anti-obesity activity of methanolic extract of D.bipinnata plant aerial parts at doses 200 mg/kg p.o. and 400 mg/kg p.o. against the standard orlistat 50 mg/kg p.o. in models of anti-obesity activity viz. High fat induced obesity, Progesterone induced obesity model. The induction of obesity is done by diet (20 grams/animal/day) and progesterone (subcutaneous) in High fat induced obesity, Progesterone induced obesity models respectively. The study period is 28 days for both models. In both models, the plant showed anti-obesity activity significantly through the biochemical and behavioral parameters.