Comparative Evaluation of Anti-Acne Gel Containing Gomphrena Globosa L Flower Extract with Previously Reported Cream Formulation

Abstract

Cuti bacterium acnes is a cause of acne. Conventional treatments often lead to side effects and bacterial resistance, necessitating natural alternatives. Acne vulgaris is one of the most common chronic inflammatory disorders of the skin, primarily affecting adolescents and young adults. It’s occurring mainly due to excessive sebum production abnormal follicular keratinization, proliferation of Cuti bacterium acnes, and inflammation... Although it is not a life-threatening condition, acne can cause pain, post-inflammatory pigmentation, scarring, and psychological distress.

Acne gel is a topical pharmaceutical preparation developed for the management of acne vulgaris. Gels are preferred for topical acne treatment because they are non-greasy, easily spreadable, rapidly absorbed, and provide good skin contact. The prepared gel can be evaluated for physical appearance, homogeneity, pH, viscosity, spread ability, extrudability, drug content, skin irritation, and stability. The acne gel formulation refers to the prepared gel is evaluated and confirmed for its desired quality, safety, stability, and effectiveness.

Gomphrena globosa L., commonly known as globe amaranth, is a traditional medicinal plant widely used to folk medicine across Asia, Africa, and Latin America. Various plant parts, especially flowers leaves, contain rich classes of phytochemicals including phenolics, flavonoids, betacyanins, saponins, and triterpenoids. Pharmacological studies demonstrate significant antioxidant, anti-inflammatory, anticancer, and analgesic activities.