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Phytochemical Evaluation and in Vivo Antidiabetic Activity of Methanolic Extract of Artemisia Afra
Corresponding Author(s) : Noor Islam
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 14 No. 3 (2026): 2026 Volume -14 - Issue 3
Abstract
The aim of this study was to investigate the antidiabetic activity andmechanism of action of aqueous fruit extract prepared from Artemisia afra. Since this claim has not been investigated scientifically, the aim of this study was to evaluate the antidiabetic effect and phytochemical screening of alloxan-induced diabetic Mice.
The present study aimed to investigate the in vivo anti-diabetic activity of leaves of methanolic extract of Artemisia afra. It showed the blood glucose lowering activity of 80% Methanolic crude extract and solvent fraction was studied in animal models: Hypoglycemic mice model, oral glucose loaded mice model, dose-treated Alloxan-induced diabetic mice model. The effect of the crude extract on diabetic lipid profile was studied and the strongest activity was shown by Crude extract fraction (89.60% inhibition at 1000 μg/mL) compared to the standard acarbose having 97.19% inhibition at 1000 μg/mL. The crude extract of Artemisia afra showed significant blood glucose-lowering effect on hypoglycemic mice and oral glucose loaded mice. In Alloxan-induced diabetic mice model, the crude extract fraction significantly decreased the fasting blood glucose level after 14 days of treatment.
The result demonstrated the beneficial biochemical effects of Artemisia afra extract by inhibiting α–amylase improving serum lipid profile levels. The fruit crude extract is effective in lowering blood glucose levels in diabetic and hypoglycemic mice. The claimed traditional use as antidiabetic has scientific ground.